US4057631A
Expired / Lapsed
US
⏱️ 0.0 years remaining
7-(α-Substituted phenylacetamido)-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-cephem-4-carboxylic acids
Assignee: GlaxoSmithKline LLC
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Filing: 1976-09-02
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Granted: 1977-11-08
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Expires: 1996-09-02
Abstract
Abstract New semisynthetic cephalosporins characterized by having structures with a 1-carboxymethylthioethyltetrazolyl-5-thiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3- cephem-4-carboxylic acid disodium salt.
Inventors
- 👤 David A. Berges
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:51
CPC Classifications
C; C07; C07D; C07D257/00; C07D257/02; C07D257/04; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
51 words
A compound or its nontoxic alkali metal salts, said compound being of the structure: ##STR3## in which: X is thienyl, furyl, phenyl or phenyl monosubstituted with hydroxy, hydroxymethyl, formamido or ureido; and A is NH 2 , OH, COOH, SO 3 H, formyloxy or, when the α-C- hydrogen is absent, methoxyimino.
Claim 2
Dependent Claim
51 words
A compound or its nontoxic alkali metal salts, said compound being of the structure: ##STR3## in which: X is thienyl, furyl, phenyl or phenyl monosubstituted with hydroxy, hydroxymethyl, formamido or ureido; and A is NH 2 , OH, COOH, SO 3 H, formyloxy or, when the α-C- hydrogen is absent, methoxyimino.
Claim 3
Dependent Claim
8 words
The compound of claim 1 being 7-D-mandelamido-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-cephem-4-carboxylic acid.
Claim 4
Dependent Claim
10 words
The compound of claim 1 being 7-D-mandelamido-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-cephem-4-carboxylic acid disodium salt.
Claim 5
Dependent Claim
8 words
The compound of claim 1 being 7-(D-α-amino-4-hydroxyphenylacetamido)-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-cephem-4-carboxylic acid.
Claim 6
Dependent Claim
26 words
A pharmaceutical composition having antibacterial activity comprising a nontoxic antibacterially effective quantity of a compound as claimed in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 7
Dependent Claim
30 words
A method of treating bacterial infections comprising administering internally to an infected or susceptible human subject an antibacterially effective but nontoxic dose of a compound as claimed in claim 1.
References Cited (Backward Citations)
US3989694A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-07 | 1981-05-09 | 1981-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-07 | 1985-05-09 | 1985-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-07 | 1989-05-09 | 1989-11-08 | $7700.00 | Window Closed / Lapsed |