US4079134A
Expired / Lapsed
US
⏱️ 0.0 years remaining
7-Acylamino-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acids
Assignee: GlaxoSmithKline LLC
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Filing: 1976-09-24
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Granted: 1978-03-14
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Expires: 1996-09-24
Abstract
Abstract New semisynthetic cephalosporins characterized by having structures with a 5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl group at position 3. Exemplary is the anti-bacterially effective 7-D-mandelamido-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-ce phem-4-carboxylic acid disodium salt.
Inventors
- 👤 David A. Berges
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 08:21
CPC Classifications
C; C07; C07D; C07D285/00; C07D285/01; C07D285/02; C07D285/04; C07D285/12; C07D285/125; C07D249/00; C07D249/02; C07D249/08; C07D249/10; C07D249/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
50 words
A compound of the structural formula: ##STR3## in which: X is thienyl, furyl, phenyl or phenyl monosubstituted with hydroxy, hydroxymethyl, formamido or ureido; and A is NH 2 , OH, COOH, SO 3 H, formyloxy or when the α-C-hydrogen is absent, methoxyimino; or its nontoxic pharmaceutically acceptable alkali metal salts.
Claim 2
Dependent Claim
50 words
A compound of the structural formula: ##STR3## in which: X is thienyl, furyl, phenyl or phenyl monosubstituted with hydroxy, hydroxymethyl, formamido or ureido; and A is NH 2 , OH, COOH, SO 3 H, formyloxy or when the α-C-hydrogen is absent, methoxyimino; or its nontoxic pharmaceutically acceptable alkali metal salts.
Claim 3
Dependent Claim
8 words
The compound of claim 1 being 7-D-mandelamido-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid.
Claim 4
Dependent Claim
10 words
The compound of claim 1 being 7-D-mandelamido-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid disodium salt.
Claim 5
Dependent Claim
8 words
The compound of claim 1 being 7-(D-α-amino-4-hydroxyphenylacetamido)-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid.
Claim 6
Dependent Claim
20 words
A pharmaceutical composition having antibacterial activity comprising a compound as claimed in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 7
Dependent Claim
30 words
A method of treating bacterial infections comprising administering internally to an infected or susceptible human subject an antibacterially effective but nontoxic dose of a compound as claimed in claim 1.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-13 | 1981-09-12 | 1982-03-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-13 | 1985-09-12 | 1986-03-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-13 | 1989-09-12 | 1990-03-14 | $7700.00 | Window Closed / Lapsed |