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US4376777A
Expired / Lapsed
US
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Thiazolidine derivatives use
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1981-01-06
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Granted: 1983-03-15
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Expires: 2001-01-06
Abstract
Abstract A thiazolidine derivative of the formula: ##STR1## wherein R 1 is hydrogen, hydroxyl, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms, or lower carboxylic acyloxy having 2 to 4 carbon atoms; each of R 2 and R 3 is hydroxyl, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms or lower carboxylic acyloxy having 2 to 4 carbon atoms or pharmaceutically acceptable salt thereof a is a novel compound having antiulcer activity and inhibitory effect on gastric acid secretion. The compound is useful as antiulcer agent or inhibitory agent of gastric acid secretion.
Inventors
- 👤 Yutaka Kawamatsu
- 👤 Takashi Sohda
- 👤 Takeo Hirata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 10:35
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/54; A; A61; A61P; A61P1/00; A61P1/04
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
75 words
A thiazolidine compound of the formula: ##STR9## wherein R 1 is hydrogen, hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, and each of R 2 and R 3 is hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
75 words
A thiazolidine compound of the formula: ##STR9## wherein R 1 is hydrogen, hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, and each of R 2 and R 3 is hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
29 words
A thiazolidine compound as claimed in claim 1, wherein R 1 is hydrogen and each of R 2 and R 3 is alkoxy having 1 to 4 carbon atoms.
Claim 4
Dependent Claim
27 words
A thiazolidine compound as claimed in claim 1, wherein each of R 1 , R 2 and R 3 is alkoxy having 1 to 4 carbon atoms.
Claim 5
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(2,4-dimethoxybenzyl)thiazolidine-2,4-dione.
Claim 6
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(2,4,5-tripropoxybenzyl)thiazolidine-2,4-dione.
Claim 7
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(3,4-dimethoxybenzyl)thiazolidine-2,4-dione.
Claim 8
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(3,4-diethoxybenzyl)thiazolidine-2,4-dione.
Claim 9
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(2,4,5-trimethoxybenzyl)thiazolidine-2,4-dione.
Claim 10
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(2,4,5-triethoxybenzyl)thiazolidine-2,4-dione.
Claim 11
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(3,4,5-trimethoxybenzyl)thiazolidine-2,4-dione.
Claim 12
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(3-ethoxy-4-acetoxybenzyl)thiazolidine-2,4-dione.
Claim 13
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(3,4-dihydroxybenzyl)thiazolidine-2,4-dione.
Claim 14
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(3,4-dimethylbenzyl)thiazolidine-2,4-dione.
Claim 15
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(2-hydroxy-3-methoxybenzyl)thiazolidine-2,4-dione.
Claim 16
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(3,5-diethoxybenzyl)thiazolidine-2,4-dione.
Claim 17
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(3,5-dimethoxybenzyl)thiazolidine-2,4-dione.
Claim 18
Dependent Claim
13 words
A thiazolidine compound as claimed in claim 1, wherein the compound is 5-(2,3-dimethoxybenzyl)thiazolidine-2,4-dione.
Claim 19
Independent Claim
96 words
A method for treatment of a mammal suffering from an ulcer, which comprises administering to said mammal an effective amount of a thiazolidine compound of the formula: ##STR10## wherein R 1 is hydrogen, hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, and each of R 2 and R 3 is hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 20
Independent Claim
96 words
A method for treatment of a mammal suffering from an ulcer, which comprises administering to said mammal an effective amount of a thiazolidine compound of the formula: ##STR10## wherein R 1 is hydrogen, hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, and each of R 2 and R 3 is hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 21
Dependent Claim
109 words
A medicinal composition for the treatment of a mammal suffering from an ulcer, which comprises: (A) as an active ingredient, an effective amount of a thiazolidine compound of the formula: ##STR11## wherein R 1 is hydrogen, hydroxy, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, and each of R 2 and R 3 is hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof, and (B) a physiologically acceptable carrier, excipient or diluent therefor.
Claim 22
Dependent Claim
109 words
A medicinal composition for the treatment of a mammal suffering from an ulcer, which comprises: (A) as an active ingredient, an effective amount of a thiazolidine compound of the formula: ##STR11## wherein R 1 is hydrogen, hydroxy, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, and each of R 2 and R 3 is hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof, and (B) a physiologically acceptable carrier, excipient or diluent therefor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-03-14 | 1986-09-13 | 1987-03-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-03-14 | 1990-09-13 | 1991-03-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-03-14 | 1994-09-13 | 1995-03-15 | $7700.00 | Window Closed / Lapsed |