← Back to Patent Explorer
US4287200A Expired / Lapsed US ⏱️ 0.0 years remaining

Thiazolidine derivatives

Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1979-07-27
•
Granted: 1981-09-01
•
Expires: 1999-07-27
📄 Original PDF 🌐 Google Patents 🔄 Sync Now

Abstract

Abstract Thiazolidine derivatives of the general formula: <IMAGE> [wherein R1 is alkyl, cycloalkyl, phenylalkyl, phenyl, a five- or six-membered heterocyclic group including one or two hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur or a group of the formula <IMAGE> (where R3 and R4 are the same or different and each is lower alkyl or R3 and R4 are combined to each other either directly or as interrupted by a hetero-atom selected from the group consisting of nitrogen, oxygen and sulfur to form a five- or six-membered ring); R2 means a bond or a lower alkylene group; L1 and L2 are the same or different and each is lower alkyl or L1 and L2 are combined to form an alkylene group, provided that when R1 is other than alkyl, L1 and L2 may further be hydrogen, respectively] are novel compounds and useful as, for example, remedies for diabetes, hyperlipemia and so on of mammals including human beings.

Inventors

  • 👤 Yutaka Kawamatsu
  • 👤 Takeshi Fujita

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-29 22:15
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/54; A; A61; A61P; A61P3/00; A61P3/06; A61P3/08; A61P3/10; A61P9/00; A61P9/10

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 91 words
A thiazolidine derivative of the general formula: ##STR79## wherein R 1 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenylalkyl of 7 to 11 carbon atoms, or phenyl; R 2 means a bond or a lower alkylene group; L 1 and L 2 are the same or different and each is lower alkyl or L 1 and L 2 are combined to form an alkylene group, provided that when R 1 is other than alkyl, L 1 and L 2 may further be hydrogen.
Claim 2
Dependent Claim 91 words
A thiazolidine derivative of the general formula: ##STR79## wherein R 1 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenylalkyl of 7 to 11 carbon atoms, or phenyl; R 2 means a bond or a lower alkylene group; L 1 and L 2 are the same or different and each is lower alkyl or L 1 and L 2 are combined to form an alkylene group, provided that when R 1 is other than alkyl, L 1 and L 2 may further be hydrogen.
Claim 3
Dependent Claim 20 words
A thiazolidine derivative as claimed in claim 1, wherein R 1 is an alkyl having 1 to 10 carbon atoms.
Claim 4
Dependent Claim 27 words
A thiazolidine derivative as claimed in claim 1, wherein L 1 and L 2 are combined to form an alkylene group having 2 to 6 carbon atoms.
Claim 5
Dependent Claim 22 words
A thiazolidine derivative as claimed in claim 1, wherein R 2 is a lower alkylene groups having 1 to 3 carbon atoms.
Claim 6
Dependent Claim 52 words
A thiazolidine derivative as claimed in claim 1, wherein R 1 is an alkyl having 1 to 10 carbon atoms; L 1 and L 2 are combined to form an alkylene group having 2 to 6 carbon atoms; and R 2 is a lower alkylene group having 1 to 3 carbon atoms.
Claim 7
Dependent Claim 13 words
A thiazolidine derivative as claimed in claim 1, wherein the derivative is 5-[4-(1-methylcylohexylmethyloxy)benzyl]thiazolidine-2,4-dione.
Claim 8
Dependent Claim 22 words
A hypolipidemic and hypoglycemic pharmaceutical composition, which comprises, as active ingredient, the effective amount of a thiazolidine derivative defined in claim 1.
Claim 9
Dependent Claim 16 words
A hypolipidemic and hypoglycemic pharmaceutical composition as claimed in claim 1, wherein the derivative is 5-[4-(1-methylcyclohexylmethyloxy)benzyl]thiazolidine-2,4-dione.

References Cited (Backward Citations)

US3825553A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1984-08-31 1985-03-02 1985-09-01 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1988-08-31 1989-03-02 1989-09-01 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1992-08-31 1993-03-02 1993-09-01 $7700.00 Window Closed / Lapsed

Assigned Categories & Tags

No categories assigned to this patent yet.

Assign Category Tag