Patent US4373217A successfully refreshed from Google Patents.
US4373217A
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Implantation materials and a process for the production thereof
Assignee: Merck Patent GmbH
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Filing: 1980-02-15
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Granted: 1983-02-15
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Expires: 2000-02-15
Abstract
Abstract An implantation material comprises a polymeric base of an acrylate, a polymethacrylate, a copolymer of an acrylate and a methacrylate or a mixture thereof, and 5-35% by weight of resorbable tricalcium phosphate of a particle size of 50-300 μm, and an available pore volume of less than 0.1 ml/g.
Inventors
- 👤 Klaus Draenert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:01
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61L27/40; A61L27/44; A61L27/46; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
49 words
An implantation material comprising a polymeric base of a polyacrylate, a polymethacrylate, a copolymer of an acrylate and a methacrylate or a mixture thereof and 5-35% by weight of resorbable tricalcium phosphate of a particle size of 50-300 μm and an available pore volume of less than 0.1 ml/g.
Claim 2
Dependent Claim
49 words
An implantation material comprising a polymeric base of a polyacrylate, a polymethacrylate, a copolymer of an acrylate and a methacrylate or a mixture thereof and 5-35% by weight of resorbable tricalcium phosphate of a particle size of 50-300 μm and an available pore volume of less than 0.1 ml/g.
Claim 3
Dependent Claim
11 words
The material of claim 1, further comprising a pharmacologically active agent.
Claim 4
Dependent Claim
12 words
The material of claim 2, wherein the active agent is an antibiotic.
Claim 5
Dependent Claim
11 words
The material of claim 2, wherein gentamycin is the active agent.
Claim 6
Dependent Claim
36 words
The material of claim 1, wherein the resorbable tricalcium phosphate has been prepared by sintering calcium-containing and phosphorus-containing compounds which directly produces a resorbable tricalcium phosphate having an available pore volume of less than 0.1 ml/g.
Claim 7
Dependent Claim
49 words
The material of claim 1, wherein the resorbable tricalcium phosphate has been prepared by impregnating the pores of a tricalcium phosphate of an available pore volume greater than 0.1 ml/g with a resorbable physiologically compatible filler such that the available pore volume is decreased to less than 0.1 ml/g.
Claim 8
Dependent Claim
32 words
The material of claim 1, which is formed by mixing particles of a prepolymer of the polymeric base, a polymerization catalyst, a liquid acrylic or methacrylic monomer and the resorbable tricalcium phosphate.
Claim 9
Dependent Claim
17 words
The material of claim 7, wherein the particles of prepolymer have a diameter of approximately 10-80 μm.
Claim 10
Dependent Claim
23 words
The material of claim 8, wherein the particles of prepolymer are irregular granules, flakes or thread-like cylinders of a length of 0.1-2 mm.
Claim 11
Dependent Claim
62 words
A method of preparing an implantation material having a polymeric base of a polyacrylate, a polymethacrylate, a copolymer of an acrylate and a methacrylate or a mixture thereof comprising preparing the implantation material in its moldable stage and, prior to the curing thereof, compressing the moldable implantation material thereby removing occluded air therefrom, wherein the implantation material is that of claim 7.
Claim 12
Dependent Claim
20 words
The process of claim 10, wherein the implantation material is compressed under a pressure of approximately 10-45 kp/cm 2 .
Claim 13
Dependent Claim
56 words
A composition for use in preparing an implantation material comprising 10-50 wt.% of resorbable tricalcium phosphate of a particle size of 50-300 μm and an available pore volume of less than 0.1 ml/g and 50-90 wt.% of prepolymer particles of a polyacrylate, a polymethacrylate, a copolymer of an acrylate and a methacrylate or a mixture thereof.
Claim 14
Dependent Claim
56 words
A composition for use in preparing an implantation material comprising 10-50 wt.% of resorbable tricalcium phosphate of a particle size of 50-300 μm and an available pore volume of less than 0.1 ml/g and 50-90 wt.% of prepolymer particles of a polyacrylate, a polymethacrylate, a copolymer of an acrylate and a methacrylate or a mixture thereof.
Claim 15
Dependent Claim
42 words
A composition for use in preparing an implantation material comprising 10-60 wt.% of resorbable tricalcium phosphate of a particle size of 50-300 μm with an available pore volume of less than 0.1 ml/g and 40-90 wt.% of an acrylic or methacrylic monomer.
Claim 16
Dependent Claim
42 words
A composition for use in preparing an implantation material comprising 10-60 wt.% of resorbable tricalcium phosphate of a particle size of 50-300 μm with an available pore volume of less than 0.1 ml/g and 40-90 wt.% of an acrylic or methacrylic monomer.
Claim 17
Dependent Claim
33 words
A kit for preparing an implantation material comprising a container of 8-10 wt. parts of the composition of claim 12 and a container of 2-4 wt. parts of an acrylic or methacrylic monomer.
Claim 18
Dependent Claim
47 words
A kit for preparing an implantation material comprising a container of 5-8 wt. parts of the composition of claim 13 and a container of 4-9 wt. parts of prepolymer particles of a polyacrylate, a polymethacrylate, a copolymer of an acrylate and a methacrylate or a mixture thereof.
Claim 19
Dependent Claim
32 words
A method of treating bone defects requiring implantation of a bone cement in a bone of a patient, comprising implanting the implantation material of claim 1 in a bone of the patient.
Claim 20
Dependent Claim
21 words
An implantation material of claim 1 wherein the available pore volume of the resorbable tricalcium phosphate is less than 0.05 ml/g.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-02-14 | 1986-08-16 | 1987-02-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-02-14 | 1990-08-16 | 1991-02-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-02-14 | 1994-08-16 | 1995-02-15 | $7700.00 | Window Closed / Lapsed |