US4059684A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bone cement compositions containing gentamycin
Assignee: Kulzer GmbH
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Filing: 1976-02-09
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Granted: 1977-11-22
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Expires: 1996-02-09
Abstract
Abstract A bone cement composition includes, as the principal component, powdered copolymers of methyl methacrylate and methyl acrylate, or monomeric methyl methacrylate, and, in addition, gentamicin hydrochloride and/or gentamicin hydrobromide, or a mixture of gentamicin sulfate with sodium chloride, potassium chloride, sodium bromide and/or potassium bromide. The bone cement composition is used, for example, for cementing implants in place, for the anchoring of endoprostheses of the joints, in the treatment of skull defects, and for carrying out spinal fusions. The composition provides for antibiotic release in higher concentrations to prevent infections.
Inventors
- 👤 Albert Gross
- 👤 Roland Schaefer
- 👤 Siegfried Reiss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:46
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L24/00; A61L24/001; A61L24/0015; A61L24/04; A61L24/06; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
125 words
A bone cement comprising the composition A or B, wherein: A comprises as the principal component a powdered copolymer of methyl methacrylate and methyl acrylate and 1.25 to 5 weight percent gentamycin in the form of the hydrochloride hydrobromide or 1.25 to 5 weight percent gentamycin in the form of the sulfate in admixture with 0.5 to 10 weight percent of sodium chloride, potassium chloride, sodium bromide or potassium bromide, and B comprises as the principal component monomeric methyl methacrylate and 2.5 to 10 weight percent gentamycin in the form of the hydrochloride hydrobromide or 2.5 to 10 weight percent of gentamycin in the form of the sulfate together with 1 to 20 weight percent of sodium chloride, potassium chloride, sodium bromide or potassium bromide.
Claim 2
Dependent Claim
125 words
A bone cement comprising the composition A or B, wherein: A comprises as the principal component a powdered copolymer of methyl methacrylate and methyl acrylate and 1.25 to 5 weight percent gentamycin in the form of the hydrochloride hydrobromide or 1.25 to 5 weight percent gentamycin in the form of the sulfate in admixture with 0.5 to 10 weight percent of sodium chloride, potassium chloride, sodium bromide or potassium bromide, and B comprises as the principal component monomeric methyl methacrylate and 2.5 to 10 weight percent gentamycin in the form of the hydrochloride hydrobromide or 2.5 to 10 weight percent of gentamycin in the form of the sulfate together with 1 to 20 weight percent of sodium chloride, potassium chloride, sodium bromide or potassium bromide.
Claim 3
Dependent Claim
17 words
A bone cement according to claim 1 comprising a powdered copolymer of methyl methacrylate and methyl acrylate.
Claim 4
Dependent Claim
7 words
Composition of claim 1 containing gentamicin hydrochloride.
Claim 5
Dependent Claim
13 words
Composition of claim 1 containing a mixture of gentamicin sulfate and sodium chloride.
Claim 6
Dependent Claim
13 words
Composition of claim 1 containing a mixture of gentamicin sulfate and potassium bromide.
Claim 7
Dependent Claim
22 words
Composition of claim 1 wherein a catalyst, especially dibenzoyl peroxide, is contained in the powdered copolymers of methyl methacrylate and methyl acrylate.
Claim 8
Dependent Claim
17 words
Composition of claim 1 wherein a reducing component, especially dimethyl-p-toluidine, is contained in the monomeric methyl methacrylate.
Claim 9
Dependent Claim
21 words
Composition of claim 1 wherein an x-ray contrast agent is added to the powdered copolymerizates of methyl methacrylate and methyl acrylate.
Claim 10
Dependent Claim
23 words
Composition of claim 1 comprising monomeric methacrylate and 2.5 to 10 weight percent of gentamycin in the form of the hydrochloride or hydrobromide.
Claim 11
Dependent Claim
63 words
A composition according to claim 1 comprising a powdered copolymer of methyl methacrylate and methyl acrylate and 1.25 to 5 weight percent gentamycin in the form of the sulfate in admixture with 0.5 to 10 weight percent of a salt mixture of 95 weight percent sodium chloride, 2 weight percent potassium chloride, 2 weight percent calcium chloride and 1 weight percent sodium bicarbonate.
Claim 12
Dependent Claim
14 words
Use of the composition of claim 1 for the preparation of hardened, implantable articles.
Claim 13
Dependent Claim
15 words
Use of the composition of claim 1 for the preparation of hardened, implantable, spherical articles.
Claim 14
Dependent Claim
39 words
Composition of claim 1 comprising monomeric methyl methacrylate and 2.5 to 10 weight percent of gentamycin in the form of the sulfate together with 1 to 20 weight percent of sodium chloride, potassium chloride, sodium bromide or potassium bromide.
References Cited (Backward Citations)
DE2022117A1
Cited
US3915955A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-21 | 1981-05-23 | 1981-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-21 | 1985-05-23 | 1985-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-21 | 1989-05-23 | 1989-11-22 | $7700.00 | Window Closed / Lapsed |