Compositions and method for reducing elution of therapeutic agents from teeth

Claim 2

A dentifrice composition for substantially effectively coating previously fluoride-treated teeth and thereby reducing elution of said fluoride from said teeth, said composition comprising a fluoride-containing caries prophylactic agent provided that said agent is substantially free from polyvalent metal atoms; and at least about 0.05% by weight of an anionic, non-polymeric, non-fluorinated, water-dispersible, membrane-forming material which, when applied to the surface of said previously fluoride-treated teeth in an oral environment, complexes with the calcium of said teeth and forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied fluoride from said teeth and which, when at equilibrium with the complex, has a formation constant in the range of about 0.5 to 8, said anionic membrane-forming material having the formula R 1 Z wherein R 1 is a nonionic aliphatic radical and Z is an anionic terminal group selected from --COOM ═POOM --OPO(OM).sub.2 --SO.sub.2 OM --OSO.sub.2 OM --PS(SM).sub.2 ═PSSM wherein M is selected from hydrogen, alkali metals, ammonium and amine groups.

Claim 3

A dentifrice composition for substantially effectively coating previously fluoride-treated teeth and thereby reducing elution of said fluoride from said teeth, said composition comprising a fluoride-containing caries prophylactic agent provided that said agent is substantially free from polyvalent metal atoms; and at least about 0.05% by weight of an anionic, non-polymeric, non-fluorinated, water-dispersible, membrane-forming material which, when applied to the surface of said previously fluoride-treated teeth in an oral environment, complexes with the calcium of said teeth and forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied fluoride from said teeth and which, when at equilibrium with the complex, has a formation constant in the range of about 0.5 to 8, said anionic membrane-forming material being selected from materials of the formulae R.sup.5 COOM (R.sup.6 O).sub.m PO(OM).sub.3-m R.sup.6 SO.sub.2 OM R.sup.6 CON(R.sup.2)R.sup.3 COOM R.sup.6 CONHOH wherein R 2 is selected from hydrogen and alkyl groups having from 1 to 6 carbon atoms, aryl groups, cycloalkyl groups, alkaryl groups, and aralkyl groups; R 3 is selected from alkylene, arylene, alkarylene, chloro-substituted alkylene groups and aralkylene groups containing from 1 to 12 carbon atoms; R 5 is a hydrocarbon group consisting from 6 to 24 carbon atoms; R 6 is a hydrocarbon group containing from 10 to 20 carbon atoms; M is selected from hydrogen, alkali metals, ammonium, and amine groups; and m is 1 or 2.

Claim 4

A dentifrice composition for substantially effectively coating previously fluoride-treated teeth and thereby reducing elution of said fluoride from said teeth, said composition comprising a fluoride-containing caries prophylactic agent provided that said agent is substantially free from polyvalent metal atoms; and at least about 0.05% by weight of an anionic, non-polymeric, non-fluorinated, water-dispersible, membrane-forming material which, when applied to the surface of said previously fluoride-treated teeth in an oral environment, complexes with the calcium of said teeth and forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied fluoride from said teeth and which, when at equilibrium with the complex, has a formation constant in the range of about 0.5 to 8, said anionic membrane-forming material being selected from materials of the formulae R.sup.5 COOM (R.sup.6 O).sub.m PO(OM).sub.3-m R.sup.6 SO.sub.2 OM R.sup.6 CON(R.sup.2)R.sup.3 COOM R.sup.6 CONHOH wherein R 2 is selected from hydrogen and alkyl groups having from 1 to 6 carbon atoms, aryl groups, cycloalkyl groups, alkaryl groups, and aralkyl groups; R 3 is selected from alkylene, arylene, alkarylene, chloro-substituted alkylene groups and aralkylene groups containing from 1 to 12 carbon atoms; R 5 is a hydrocarbon group consisting from 6 to 24 carbon atoms; R 6 is a hydrocarbon group containing from 10 to 20 carbon atoms; M is selected from hydrogen, alkali metals, ammonium, and amine groups; and m is 1 or 2.

Claim 5

A dentifrice composition according to claim 2 wherein said membrane-forming material has the formula R 5 COOM.

Claim 6

A dentifrice composition according to claim 3 wherein said membrane-forming material is selected from lauric, myristic, palmitic, stearic and oleic acids.

Claim 7

A dentifrice composition according to claim 2 wherein said membrane-forming material has the formula [R.sup.6 O].sub.m PO(OM).sub.3-m.

Claim 8

A dentifrice composition according to claim 5 wherein said membrane-forming material is selected from (C 16 H 33 O) 2 POOH and (C 18 H 37 O) 2 POOH.

Claim 9

A dentifrice composition according to claim 2 wherein said membrane-forming material has the formula R 6 SO 2 OM.

Claim 10

A dentifrice composition according to claim 7 wherein said membrane-forming material is selected from ##STR17##

Claim 11

A dentifrice composition according to claim 2 wherein said membrane forming material has the formula R 6 CON(R 2 )R 3 COOM.

Claim 12

A dentifrice composition according to claim 9 wherein said membrane-forming material is C 11 H 23 CON(CH 3 )CH 2 COONa.

Claim 13

A dentifrice composition according to claim 2 wherein said membrane-forming material has the formula R 6 CONHOH.