Patent US4361565A successfully refreshed from Google Patents.
US4361565A
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2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines
Assignee: Mead Johnson and Co LLC
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Filing: 1981-12-28
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Granted: 1982-11-30
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Expires: 2001-12-28
Abstract
Abstract 1-[4-(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]piperazines with 2-2-(3-cyano)pyridyl substituents in the 4- position have been synthesized and demonstrate useful psychotropic properties.
Inventors
- 👤 Davis L. Temple, Jr.
- 👤 Joseph P. Yevich
- 👤 Walter G. Lobeck, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:49
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/14; C07D401/02; C07D401/12; A; A61; A61P; A61P25/00; A61P25/18; A61P25/20; C07C; C07C51/00; C07C55/00; C07C55/02; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/86; C07D211/88; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/84; C07D213/85; C07D487/00; C07D487/02; C07D487/10
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
52 words
A compound selected from the group consisting of a compound having Formula (I) ##STR15## wherein R 1 and R 2 are independently selected from C 1 to C 4 alkyl groups; with Z being hydrogen; halogen or pseudohalogen, preferably fluoro, chloro, or trifluoromethyl and the non-toxic pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
52 words
A compound selected from the group consisting of a compound having Formula (I) ##STR15## wherein R 1 and R 2 are independently selected from C 1 to C 4 alkyl groups; with Z being hydrogen; halogen or pseudohalogen, preferably fluoro, chloro, or trifluoromethyl and the non-toxic pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
9 words
A compound of claim 1 wherein Z is 5-fluoro.
Claim 4
Dependent Claim
14 words
The compound of claim 1, 2-[4-[4-(4,4-dimethyl-2,6-dioxo-1-piperidinyl)butyl]-1-piperazinyl]-3-pyridincarbonitrile or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
14 words
The compound of claim 1, 2-[4-[4-(4,4-diethyl-2,6-dioxo-1-piperidinyl)butyl]-1-piperazinyl]-3-pyridincarbonitrile or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
14 words
The compound of claim 1, 2-[4-[4-(4-methyl-2,6-dioxo-4-propyl-1-piperidinyl)butyl]-1-piperazinyl]-3-pyridincarbonitrile or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
43 words
The process for ameliorating an undesirable anxiety/antipsychotic state in a mammal comprising systemic administration to said mammal of an effective psychotropic dose of from 0.01 to 40 mg/kg body weight of a Formula (I) compound or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
43 words
The process for ameliorating an undesirable anxiety/antipsychotic state in a mammal comprising systemic administration to said mammal of an effective psychotropic dose of from 0.01 to 40 mg/kg body weight of a Formula (I) compound or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Dependent Claim
44 words
A pharmaceutical composition in dosage unit form suitable for systemic administration to a mammalian host comprising a pharmaceutical carrier and an amount of a Formula (I) compound to provide an effective non-toxic dose of from 0.01 to 40 mg/kg body weight of said host.
Claim 10
Dependent Claim
44 words
A pharmaceutical composition in dosage unit form suitable for systemic administration to a mammalian host comprising a pharmaceutical carrier and an amount of a Formula (I) compound to provide an effective non-toxic dose of from 0.01 to 40 mg/kg body weight of said host.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-29 | 1986-05-31 | 1986-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-29 | 1990-05-31 | 1990-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-29 | 1994-05-31 | 1994-11-30 | $7700.00 | Window Closed / Lapsed |