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US4355026A
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US
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4-Demethoxy,11-deoxy anthracycline derivatives
Assignee: Microbial Chemistry Research Foundation
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Filing: 1981-09-11
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Granted: 1982-10-19
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Expires: 2001-09-11
Abstract
Abstract New 4-demethoxy-11-deoxydaunomycin and 4-demethoxy-11-deoxyadriamycin anthracycline derivatives have been prepared and found to be useful antimicrobial and antitumor agents.
Inventors
- 👤 Hamao Umezawa
- 👤 Tomio Takeuchi
- 👤 Hiroshi Naganawa
- 👤 Kuniaki Tatsuta
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 10:25
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/02; C07D307/26; C07D307/30; C07D307/32; A; A61; A61P; A61P35/00; C07C; C07C43/00; C07C43/02; C07C43/20; C07C43/215; C07C45/00; C07C45/26; C07D309/00; C07D309/16; C07D309/28; C07D309/30; C07H; C07H13/00; C07H13/02; C07H13/08; C07H15/00; C07H15/20; C07H15/24; C07H15/252; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
23 words
An anthracycline glycoside of the general formula ##STR36## wherein R 1 represents hydrogen, hydroxyl or (lower)alkanoyloxy, or a nontoxic acid addition salt thereof.
Claim 2
Dependent Claim
23 words
An anthracycline glycoside of the general formula ##STR36## wherein R 1 represents hydrogen, hydroxyl or (lower)alkanoyloxy, or a nontoxic acid addition salt thereof.
Claim 3
Dependent Claim
20 words
A compound according to claim 1 wherein R 1 is hydrogen or hydroxyl, or a nontoxic acid addition salt thereof.
Claim 4
Dependent Claim
13 words
A compound according to claim 1 or claim 2 having a (7S,9S) configuration.
Claim 5
Dependent Claim
18 words
A compound according to claim 1 or claim 2 wherein the amino sugar residue has a 1'α linkage.
Claim 6
Dependent Claim
14 words
The anthracycline glycoside of the formula ##STR37## or a nontoxic acid addition salt thereof.
Claim 7
Dependent Claim
14 words
The anthracycline glycoside of the formula ##STR37## or a nontoxic acid addition salt thereof.
Claim 8
Dependent Claim
21 words
The isomer of the compound according to claim 5 which has the configuration (7S,9S,1'α), or a nontoxic acid addition salt thereof.
Claim 9
Dependent Claim
21 words
The isomer of the compound according to claim 5 which has the configuration (7S,9S,1'β), or a nontoxic acid addition salt thereof.
Claim 10
Dependent Claim
21 words
The isomer of the compound according to claim 5 which has the configuration (7R,9R,1'α), or a nontoxic acid addition salt thereof.
Claim 11
Dependent Claim
21 words
The isomer of the compound according to claim 5 which has the configuration (7R,9R,1'β), or a nontoxic acid addition salt thereof.
Claim 12
Dependent Claim
14 words
The anthracycline glycoside of the formula ##STR38## or a nontoxic acid addition salt thereof.
Claim 13
Dependent Claim
14 words
The anthracycline glycoside of the formula ##STR38## or a nontoxic acid addition salt thereof.
Claim 14
Dependent Claim
21 words
The isomer of the compound according to claim 10 which has the configuration (7S,9S,1'α), or a nontoxic acid addition salt thereof.
Claim 15
Dependent Claim
21 words
The isomer of the compound according to claim 10 which has the configuration (7R,9R,1'α), or a nontoxic acid addition salt thereof.
Claim 16
Dependent Claim
15 words
An aglycone intermediate of the formula ##STR39## wherein R 1 represents hydrogen, hydroxyl or (lower)alkanoyloxy.
Claim 17
Dependent Claim
15 words
An aglycone intermediate of the formula ##STR39## wherein R 1 represents hydrogen, hydroxyl or (lower)alkanoyloxy.
Claim 18
Dependent Claim
11 words
The compound according to claim 13 wherein R 1 is hydrogen.
Claim 19
Dependent Claim
11 words
The compound according to claim 13 wherein R 1 is hydroxyl.
Claim 20
Dependent Claim
11 words
The compound according to claim 13 wherein R 1 is (lower)alkanoyloxy.
Claim 21
Dependent Claim
11 words
The compound according to claim 16 wherein R 1 is acetoxy.
Claim 22
Dependent Claim
20 words
A compound according to claim 13, 14, 15, 16 or 17 in the form of the racemic mixture (7S,9S; 7R,9R).
Claim 23
Dependent Claim
6 words
An intermediate of the formula ##STR40##
Claim 24
Dependent Claim
6 words
An intermediate of the formula ##STR40##
Claim 25
Dependent Claim
35 words
A pharmaceutical composition for use in therapeutically treating a mammalian host affected by a microbial infection comprising a therapeutically effective amount of a compound as claimed in claim 1 and a pharmaceutical carrier or diluent.
Claim 26
Dependent Claim
34 words
A pharmaceutical composition for use in therapeutically treating a mammalian host affected by L 1210 leukemia comprising a tumor-inhibiting amount of a compound as claimed in claim 1 and a pharmaceutical carrier or diluent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-10-18 | 1986-04-19 | 1986-10-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-10-18 | 1990-04-19 | 1990-10-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-10-18 | 1994-04-19 | 1994-10-19 | $7700.00 | Window Closed / Lapsed |