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US4354952A Expired / Lapsed US ⏱️ 0.0 years remaining

Contact lens disinfecting and preserving solution comprising chlorhexidine and salts thereof

Assignee: Bausch and Lomb Inc
•
Filing: 1981-03-12
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Granted: 1982-10-19
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Expires: 2001-03-12
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Abstract

Abstract A disinfecting and/or preserving solution for contact lenses is disclosed. The disinfecting solution is an aqueous solution containing 0.0035 to 0.04 weight percent of an amphoteric surfactant in combination with 0.0005 to 0.01 weight percent of chlorhexidine and 0.002 to 0.025 weight percent of a non-ionic surfactant, optionally together with up to 0.5 weight percent of thimerosal or other enhancers and optional buffers and the like. The binding (or uptake) of preservative by a hydrophilic soft contact lens is reduced by this invention.

Inventors

  • 👤 Thomas M. Riedhammer
  • 👤 Francis X. Smith

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 09:57
CPC Classifications
C; C11; C11D; C11D3/00; C11D3/0005; C11D3/0078; A; A01; A01N; A01N47/00; A01N47/40; A01N47/42; A01N47/44; A61; A61L; A61L12/00; A61L12/08; A61L12/14; A61L12/141

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 261 words
An aqueous solution for preserving and/or disinfecting soft contact lenses having as the active antimicrobial agent a combination 0.0005 to 0.01 weight percent of said composition chlorhexidine or salt thereof, 0.0035 to 0.04 weight percent of said composition of amphoteric surfactant and 0.002 to 15 weight percent of said composition of a nonionic surfactant having a hydrophiliclipophile balance between 12.4 and 18.8, said amphoteric surfactant being selected from the group consisting of: ##STR13## wherein R is a fatty acid radical having 6 to 18 carbon atoms R 1 is H or --CH 2 C(O)O provided that when R 1 is H then M 1 is absent R 2 is --CH 2 C(O)O or CH(OH)CH 2 SO 3 M and M 1 are cation salt forming groups X is OH or the acid group of an anionic surfact active agent n is an integer from 1 to 40; ##STR14## wherein R is a hydrophobe radical M is an alkali metal X is selected from CH 3 OSO, C 2 H 5 OSO 3 , Cl or Br n is an integer from 1 to 40; ##STR15## wherein R 1 is a fatty acid or hydrophobe radical R 2 is alkyl or substituted alkyl Z is sulfate or sulfonic M is alkali metal X is CH 3 OSO 3 , C 2 H 5 OSO 3 , Cl or Br; or ##STR16## wherein R is alkylene of 12-13 carbon atoms, said nonionic surfactant being selected from polyethylene glycol esters of fatty acids, polyoxyethylene ethers of higher alkanes and polyoxypropylene ethers of higher alkanes.
Claim 2
Dependent Claim 261 words
An aqueous solution for preserving and/or disinfecting soft contact lenses having as the active antimicrobial agent a combination 0.0005 to 0.01 weight percent of said composition chlorhexidine or salt thereof, 0.0035 to 0.04 weight percent of said composition of amphoteric surfactant and 0.002 to 15 weight percent of said composition of a nonionic surfactant having a hydrophiliclipophile balance between 12.4 and 18.8, said amphoteric surfactant being selected from the group consisting of: ##STR13## wherein R is a fatty acid radical having 6 to 18 carbon atoms R 1 is H or --CH 2 C(O)O provided that when R 1 is H then M 1 is absent R 2 is --CH 2 C(O)O or CH(OH)CH 2 SO 3 M and M 1 are cation salt forming groups X is OH or the acid group of an anionic surfact active agent n is an integer from 1 to 40; ##STR14## wherein R is a hydrophobe radical M is an alkali metal X is selected from CH 3 OSO, C 2 H 5 OSO 3 , Cl or Br n is an integer from 1 to 40; ##STR15## wherein R 1 is a fatty acid or hydrophobe radical R 2 is alkyl or substituted alkyl Z is sulfate or sulfonic M is alkali metal X is CH 3 OSO 3 , C 2 H 5 OSO 3 , Cl or Br; or ##STR16## wherein R is alkylene of 12-13 carbon atoms, said nonionic surfactant being selected from polyethylene glycol esters of fatty acids, polyoxyethylene ethers of higher alkanes and polyoxypropylene ethers of higher alkanes.
Claim 3
Dependent Claim 41 words
The composition of claim 1 wherein the amount of amphoteric surfactant is from 0.007 to 0.02 weight percent, the chlorhexidine or salt thereof is from 0.002 to 0.01 weight percent and the nonionic surfactant is from 0.002 to 0.025 weight percent.
Claim 4
Dependent Claim 49 words
The composition of claim 1 wherein an enhancing agent is present in an amount up to 0.5 weight percent and the chlorhexidine salt is chlorhexidine gluconate, said enhancing agent being selected from the group consisting of thimerosal, sorbic acid, phenylmercuric salts, ethylenediaminetetracetic acid and its salts and mixtures thereof.
Claim 5
Dependent Claim 10 words
The composition of claim 3 wherein the enhancer is thimerosal.
Claim 6
Dependent Claim 16 words
The composition of claim 3 wherein the enchancing agent is the disodium salt of ethylenediaminetetraacetic acid.
Claim 7
Dependent Claim 21 words
The composition of claim 3 wherein the enhancer is present in an amount from about 0.0001 to about 0.1 weight percent.
Claim 8
Dependent Claim 25 words
A method of disinfecting contact lenses comprising contacting the lenses for a sufficient time to disinfect the lenses with the aqueous solution of claim 1.
Claim 9
Dependent Claim 25 words
A method of inhibiting microorganism growth in a solution for use with contact lenses comprising treating the lenses with the aqueous solution of claim 1.
Claim 10
Dependent Claim 25 words
A method of cleaning contact lenses comprising rubbing the lens with the preserved cleaning solution of claim 1 and rinsing with a preserved saline solution.
Claim 11
Dependent Claim 14 words
The method of claim 9 wherein the contact lens is a soft contact lens.

References Cited (Backward Citations)

USRE29693E Cited
US3888782A Cited
US3884826A Cited
US4013576A Cited
US4046706A Cited
US4104187A Cited
US4199567A Cited
US4259202A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1985-10-18 1986-04-19 1986-10-19 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1989-10-18 1990-04-19 1990-10-19 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1993-10-18 1994-04-19 1994-10-19 $7700.00 Window Closed / Lapsed

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