US4199567A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for imparting freeze stability to chlorhexidine-containing medicaments
Assignee: Alcon Vision LLC
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Filing: 1979-01-02
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Granted: 1980-04-22
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Expires: 1999-01-02
Abstract
Abstract Chlorhexidine gluconate containing solutions are stabilized against precipitation upon freezing by the addition thereto of certain nonionic surfactants.
Inventors
- 👤 Billy F. Rankin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 08:51
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61K31/00; A61K31/13; A61K31/155
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
60 words
A method for preventing the precipitation of chlorhexidine gluconate from a chloride ion-containing aqueous solution thereof upon exposure to freezing which comprises adding to the solution a polyoxyethylene fatty acid ester having an HLB number greater than 11 in a concentration greater than about 0.05% and less than about 0.1% but at least 10 times that of the chlorhexidine gluconate.
Claim 2
Independent Claim
60 words
A method for preventing the precipitation of chlorhexidine gluconate from a chloride ion-containing aqueous solution thereof upon exposure to freezing which comprises adding to the solution a polyoxyethylene fatty acid ester having an HLB number greater than 11 in a concentration greater than about 0.05% and less than about 0.1% but at least 10 times that of the chlorhexidine gluconate.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein said solution comprises an ophthalmic solution containing chlorhexidine gluconate in a concentration of about 0.005%.
Claim 4
Dependent Claim
17 words
The method of claim 2 wherein said fatty acid ester is a partial ester of hexitol anhydride.
Claim 5
Dependent Claim
19 words
The method of claim 2 wherein said ophthalmic solution contains sodium chloride in an amount sufficient to provide isotonicity.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-22 | 1983-10-22 | 1984-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-22 | 1987-10-22 | 1988-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-22 | 1991-10-22 | 1992-04-22 | $7700.00 | Window Closed / Lapsed |