US4352788A
Expired / Lapsed
US
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Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and X-ray contrasting materials containing these
Assignee: Bracco SpA
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Filing: 1980-07-30
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Granted: 1982-10-05
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Expires: 2000-07-30
Abstract
Abstract Compounds for use in non-ionic X-ray contrasting materials having the formula <IMAGE> in which (H0)2-3alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxymethylisopropyl, R is hydrogen or methyl, and R1 is an alkyl residue with 1 to 5 carbon atoms. These compounds possess high water-solubility as well as excellent stability against hydrolysis. Methods for preparation and use of the compounds are also disclosed.
Inventors
- 👤 Ernst Felder
- 👤 Davide Pitre
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:54
CPC Classifications
C; C07; C07D; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/28
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
34 words
5-(N-alkyl-.alpha.-hydroxyacylamino)-2,4,6-triiodoisophthalic-acid-bis-(hydroxyalkylamides) having the formula (I) ##STR7## in which (OH) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxy-methyl-isopropyl, R is hydrogen or methyl, and R 1 is an alkyl residue with 1 to 5 carbon atoms.
Claim 2
Dependent Claim
34 words
5-(N-alkyl-.alpha.-hydroxyacylamino)-2,4,6-triiodoisophthalic-acid-bis-(hydroxyalkylamides) having the formula (I) ##STR7## in which (OH) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxy-methyl-isopropyl, R is hydrogen or methyl, and R 1 is an alkyl residue with 1 to 5 carbon atoms.
Claim 3
Dependent Claim
23 words
5-(N-methyl-α-hydroxyacyl-amino)2,4,6-triiodo-isophthalic-acid-bis-(hydroxyalkylamides) having the formula (II) ##STR8## in which (HO) 2-3 alkyl is 1,3-dihydroxyisopropyl, or 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxymethylisopropyl, and R is hydrogen or methyl.
Claim 4
Dependent Claim
23 words
5-(N-methyl-α-hydroxyacyl-amino)2,4,6-triiodo-isophthalic-acid-bis-(hydroxyalkylamides) having the formula (II) ##STR8## in which (HO) 2-3 alkyl is 1,3-dihydroxyisopropyl, or 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxymethylisopropyl, and R is hydrogen or methyl.
Claim 5
Dependent Claim
1 words
5-(N-methyl-hydroxyacetyl-amino)-2,4,6-triiodo-isophthalic-acid-bis-(2,3-dihydroxypropylamide).
Claim 6
Dependent Claim
1 words
5-(N-methyl-hydroxyacetyl-amino)-2,4,6-triiodo-isophthalic-acid-bis-(2,3-dihydroxypropylamide).
Claim 7
Dependent Claim
1 words
5-(N-methyl-α-hydroxypropionyl-amino)-2,4,6-triiodo-isophthalic-acid-bis-(1,3-dihydroxyisopropylamide).
Claim 8
Dependent Claim
1 words
5-(N-methyl-α-hydroxypropionyl-amino)-2,4,6-triiodo-isophthalic-acid-bis-(1,3-dihydroxyisopropylamide).
Claim 9
Dependent Claim
52 words
In an X-ray contrasting composition containing a radio-opaque component and a pharmacologically acceptable carrier therefor, the improvement which comprises said radio-opaque component being ##STR9## in which (OH) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl, or 1,3-dihydroxy-2-hydroxy-methyl-isopropyl, R is hydrogen or methyl, and R 1 is an alkyl residue with 1 to 5 carbon atoms.
Claim 10
Dependent Claim
52 words
In an X-ray contrasting composition containing a radio-opaque component and a pharmacologically acceptable carrier therefor, the improvement which comprises said radio-opaque component being ##STR9## in which (OH) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl, or 1,3-dihydroxy-2-hydroxy-methyl-isopropyl, R is hydrogen or methyl, and R 1 is an alkyl residue with 1 to 5 carbon atoms.
Claim 11
Dependent Claim
69 words
In a method for enhancement of the visualization of vessels in a patient wherein an X-ray contrasting composition is injected into the vessel, the improvement which comprises said X-ray contrasting composition comprising a radio-opaque effective amount of ##STR10## in which (OH) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl, or 1,3-dihydroxy-2-hydroxy-methyl-iso-propyl, R is hydrogen or methyl, and R 1 is an alkyl residue with 1 to 5 carbon atoms, and a carrier.
Claim 12
Dependent Claim
69 words
In a method for enhancement of the visualization of vessels in a patient wherein an X-ray contrasting composition is injected into the vessel, the improvement which comprises said X-ray contrasting composition comprising a radio-opaque effective amount of ##STR10## in which (OH) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl, or 1,3-dihydroxy-2-hydroxy-methyl-iso-propyl, R is hydrogen or methyl, and R 1 is an alkyl residue with 1 to 5 carbon atoms, and a carrier.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1985-10-04 | 1986-04-05 | 1986-10-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-10-04 | 1990-04-05 | 1990-10-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-10-04 | 1994-04-05 | 1994-10-05 | $7700.00 | Window Closed / Lapsed |