US3678152A
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US
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Method for the x-ray visualization of body cavities and a preparation for carrying out the method
Assignee: BJORN GUSTOV ADOLF INGELMAN
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Filing: 1969-10-06
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Granted: 1972-07-18
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Expires: 1989-10-06
Abstract
Abstract Compositions which comprise at least one iodine compound of the formula: WHEREIN R1 is a lower alkyl group having no more than five carbon atoms and R2 and R3 are each a lower acyl group having no more than five carbon atoms and wherein A is an alkylene group substituted by at least one substituent of the formula -OR4 wherein R4 is a member selected from the group consisting of hydrogen, lower alkyl and lower acyl, said alkyl and acyl having each no more than five carbon atoms; said alkylene containing from three to 15 inclusive carbon atoms and optionally being broken by one or more oxygen bridges or a physiologically acceptable salt thereof. Such compositions are useful as X-ray contrast compositions and are administered to the body of the test object for the X-ray visualization of body cavities.
Inventors
- 👤 Lars Bjork
- 👤 Uno Eugen Erikson
- 👤 Bjorn Gustov-Adolf Ingelman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:04
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447; A61K49/0452; A61K49/0495
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
49 words
The method of claim 1 wherein said iodine compound has each nitrogen atom in the bridge thereof located at a distance of two carbon atoms from a group -OR4 and that no more than one oxygen is bound to one and the same carbon atom in the bridge A.
Claim 2
Dependent Claim
15 words
The method of claim 1 wherein the bridge A of the iodine compound is -CH2.CH(OR4).CH2-.
Claim 3
Dependent Claim
18 words
The method of claim 3 wherein R1 is methyl, R2 and R3 are acetyl and R4 is hydrogen.
Claim 4
Dependent Claim
53 words
The method of claim 1 wherein R1 is a member selected from the group consisting of methyl and ethyl and R2 and R3 are each a member selected from the group consisting of acetyl and propionyl and R4 is a member selected from The group consisting of hydrogen, methyl, ethyl, acetyl, and propionyl.
Claim 5
Dependent Claim
29 words
The method of claim 1 wherein the iodine compound is administered to the body of the test object in the form of a non-toxic salt in an aqueous solution.
Claim 6
Dependent Claim
21 words
The method of claim 1 wherein the iodine compound is administered to the body of the test object in solid form.
Claim 7
Independent Claim
36 words
A method for the X-ray visualization of body cavities, which comprises administering to the body of the test object a preparation containing a member selected from the group consisting of (A) iodine compounds of the formula:
Claim 8
Dependent Claim
49 words
The method of claim 8 wherein the iodine compound has each nitrogen atom in the bridge thereof located at a distance of two carbon atoms from a group -OR4 and that no more than one oxygen is bound to one and the same carbon atom in the bridge A.
Claim 9
Dependent Claim
71 words
The method of claim 8 wherein the bridge A of the iodine compound is a member selected from the group consisting of -CH2.CH(OH).CH2.O.(CH2)4.O.CH2.CH(OH).CH2- and -CH2.CH(OH).CH2.O.(CH2)2.O.CH2.CH(OH).CH2- and -CH2.CH(OH).CH2.O.CH2.CH(OH).CH2- and -CH2.CH(OH).CH2.O.CH2.CH(OH).CH2.O.CH2.CH(OH).CH2- and bridges of these formulas having at least one hydrogen atom of the hydroxyl groups replaced by a member selected from the group consisting of lower alkyl and lower alkanoyl, said alkyl and alkanoyl containing each no more than five carbon atoms.
Claim 10
Dependent Claim
16 words
The method of claim 10 wherein R1 is methyl, and R2 and R3 are each acetyl.
Claim 11
Dependent Claim
53 words
The method of claim 8 wherein R1 is a member selected from the group consisting of methyl and ethyl and R2 and R3 are each a member selected from the group consisting of acetyl and propionyl and R4 is a member selected from the group consisting of hydrogen, methyl, ethyl, acetyl and propionyl.
Claim 12
Dependent Claim
29 words
The method of claim 8 wherein the iodine compound is administered to the body of the test object in the form of a non-toxic salt in an aqueous solution.
Claim 13
Dependent Claim
21 words
The method of claim 8 wherein the iodine compound is administered to the body of the test object in solid form.
Claim 14
Dependent Claim
51 words
A preparation for the administration to the body of a test object in connection with the X-ray visualization of body cavities, consisting of an aqueous solution comprising at least one iodine compound soluble in water and being a member selected from the group consisting of (A) iodine compounds of the formula:
Claim 15
Dependent Claim
18 words
The preparation of claim 15 wherein A is an alkylene group broken by at least one oxygen atom.
Claim 16
Dependent Claim
29 words
The preparation of claim 15 wherein A is an alkylene group containing from three to 15 inclusive carbon atoms substituted by at least one substituent of the formula -OR4.
Claim 17
Dependent Claim
25 words
The preparation of claim 16 wherein said at least one iodine compound is present in an amount exceeding 10 grams per 100 ml. of solution.
Claim 18
Dependent Claim
25 words
The preparation of claim 17 wherein said at least one iodine compound is present in an amount exceeding 10 grams per 100 ml. of solution.
Claim 19
Dependent Claim
62 words
The preparation of claim 17 wherein the bridge A of the iodine compound is -CH2.CH(OR4).CH2-, R1 is a member selected from the group consisting of methyl and ethyl and R2 and R3 are each a member selected from the group consisting of acetyl and propionyl and R4 is a member selected from the group consisting of hydrogen, methyl, ethyl, acetyl and propionyl.
Claim 20
Dependent Claim
101 words
The preparation of claim 16 wherein the bridge A of the iodine compound is a member selected from the group consisting of -CH2.CH(OH).CH2.O.(CH2)4.O.CH2.CH(OH).CH2- and -CH2.CH(OH).CH2.O.(CH2)2.O.CH2.CH(OH).CH2- and -CH2.CH(OH).CH2.O.CH2.CH(OH).CH2- and -CH2.CH(OH).CH2.O.CH2.CH(OH).CH2.O.CH2.CH(OH).CH2- and bridges of these formulas hAving at least one hydrogen atom of the hydroxyl groups replaced by a member selected from the group consisting of lower alkyl and lower alkanoyl, said alkyl and alkanoyl containing each no more than five carbon atoms, R1 is a member selected from the group consisting of methyl and ethyl and R2 and R3 are each a member selected from the group consisting of acetyl and propionyl.
Claim 21
Dependent Claim
44 words
A preparation for the administration to the body of a test object in connection with the X-ray visualization of body cavities, consisting of a solid mixture comprising at least one iodine compound selected from the group consisting of (A) iodine compounds of the formula:
Claim 22
Dependent Claim
18 words
The preparation of claim 22 wherein A is an alkylene group broken by at least one oxygen atom.
Claim 23
Dependent Claim
29 words
The preparation of claim 22 wherein A is an alkylene group containing from three to 15 inclusive carbon atoms substituted by at leaSt one substituent of the formula -OR4.
References Cited (Backward Citations)
US3178473A
Cited
US3409662A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-07-18 | 1976-01-17 | 1976-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-07-18 | 1980-01-17 | 1980-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-07-18 | 1984-01-17 | 1984-07-18 | $7700.00 | Window Closed / Lapsed |