US4250113A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemical compounds
Assignee: GE Healthcare AS
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Filing: 1979-08-24
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Granted: 1981-02-10
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Expires: 1999-08-24
Abstract
Abstract Compounds of the formula: ##STR1## wherein R represents the group --CH 2 CH 2 OH or --CH 2 CHOHCH 2 OH, particularly in racemic or optically active form, are employed as active ingredients in X-ray contrast agents for intracerebral, but particularly for vascular use. The compounds are prepared by reacting 5-(N-acetamido)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide or an O-acetyl derivative thereof with an appropriate hydroxyalkylating agent and subsequently, if necessary, hydrolysing any unwanted O-acetyl groups.
Inventors
- 👤 Vegard Nordal
- 👤 Hugo Holtermann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 02:34
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433; C; C07; C07C; C07C237/00; C07C237/28; C07C237/32; C07C237/46
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
22 words
Compounds of the general formula: ##STR9## (wherein R represents the group --CH 2 CH 2 OH or --CH 2 CHOHCH 2 OH).
Claim 2
Dependent Claim
22 words
Compounds of the general formula: ##STR9## (wherein R represents the group --CH 2 CH 2 OH or --CH 2 CHOHCH 2 OH).
Claim 3
Dependent Claim
1 words
5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide.
Claim 4
Dependent Claim
1 words
5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide.
Claim 5
Dependent Claim
1 words
5-(N-2,3-Dihydroxypropyl)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide.
Claim 6
Dependent Claim
1 words
5-(N-2,3-Dihydroxypropyl)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide.
Claim 7
Dependent Claim
7 words
The compound: (+)-5-(N-2-Hydroxyethylacetamido)-2-4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide; (-)-5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide; or racemic 5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide.
Claim 8
Dependent Claim
7 words
The compound: (+)-5-(N-2-Hydroxyethylacetamido)-2-4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide; (-)-5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide; or racemic 5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-10 | 1984-08-11 | 1985-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-10 | 1988-08-11 | 1989-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-10 | 1992-08-11 | 1993-02-10 | $7700.00 | Window Closed / Lapsed |