Patent US4347358A successfully refreshed from Google Patents.
US4347358A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cephalosporin intermediates
Assignee: Gist Brocades NV
•
Filing: 1980-02-29
•
Granted: 1982-08-31
•
Expires: 2000-02-29
Abstract
Abstract Novel bromo-substituted deacetoxycephalosporins of the formula ##STR1## wherein R 1 is selected from the group consisting of benzamido, formamido, phenylacetamido and phenoxyacetamido, R 2 is selected from the group consisting of hydrogen and bromine and R 3 is a silyl group of the formula ##STR2## wherein R', R" and R'" are individually selected from the group consisting of alkyl of 1 to 6 carbon atoms, a halogen-substituted alkyl of 1 to 6 carbon atoms and aryl, which are suitable intermediates in processes for the preparation of antibiotics and their preparation.
Inventors
- 👤 Cornelis A. Bruynes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 10:18
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/02; C07D501/04; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
75 words
Bromo-substituted deacetoxycephalosporins of the formula ##STR10## wherein R 1 is selected from the group consisting of benzamido, formamido, phenylacetamido and phenoxyacetamido, R 2 is selected from the group consisting of hydrogen and bromine and R 3 is a silyl group of the formula ##STR11## wherein R', R" and R'" are individually selected from the group consisting of alkyl of 1 to 6 carbon atoms, a halogen-substituted alkyl of 1 to 6 carbon atoms and phenyl.
Claim 2
Dependent Claim
75 words
Bromo-substituted deacetoxycephalosporins of the formula ##STR10## wherein R 1 is selected from the group consisting of benzamido, formamido, phenylacetamido and phenoxyacetamido, R 2 is selected from the group consisting of hydrogen and bromine and R 3 is a silyl group of the formula ##STR11## wherein R', R" and R'" are individually selected from the group consisting of alkyl of 1 to 6 carbon atoms, a halogen-substituted alkyl of 1 to 6 carbon atoms and phenyl.
Claim 3
Dependent Claim
9 words
A compound of claim 1 which is trimethylsilyl 7-benzamido-3-bromomethyl-3-cephem-4-carboxylate-1-oxide.
Claim 4
Dependent Claim
9 words
A compound of claim 1 which is trimethylsilyl 7-benzamido-2-bromo-3-bromomethyl-3-cephem-4-carboxylate-1-oxide.
Claim 5
Dependent Claim
9 words
A compound of claim 1 which is trimethylsilyl 3-bromomethyl-7-formamido-3-cephem-4-carboxylate-1-oxide.
Claim 6
Dependent Claim
9 words
A compound of claim 1 which is trimethylsilyl 2-bromo-3-bromomethyl-7-formamido-3-cephem-4-carboxylate-1-oxide.
Claim 7
Dependent Claim
9 words
A compound of claim 1 which is trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.
Claim 8
Dependent Claim
9 words
A compound of claim 1 which is trimethylsilyl 2-bromo-3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.
Claim 9
Dependent Claim
9 words
A compound of claim 1 which is trimethylsilyl 3-bromomethyl-7-phenoxyacetamido-3-cephem-4-carboxylate-1-oxide.
Claim 10
Dependent Claim
9 words
A compound of claim 1 which is trimethylsilyl 2-bromo-3-bromomethyl-7-phenoxyacetamido-3-cephem-4-carboxylate-1-oxide.
Claim 11
Dependent Claim
9 words
A compound of claim 1 which is tri-n-propylsilyl 7-benzamido-2-bromo-3-bromomethyl-3-cephem-4-carboxylate-1-oxide.
Claim 12
Dependent Claim
9 words
A compound of claim 1 which is t-butyldimethylsilyl 7-benzamido-3-bromomethyl-3-cephem-4-carboxylate-1-oxide.
Claim 13
Dependent Claim
9 words
A compound of claim 1 which is trihexylsilyl 3-bromomethyl-7-formamido-3-cephem-4-carboxylate-1-oxide.
Claim 14
Dependent Claim
9 words
A compound of claim 1 which is t-butyldimethylsilyl 3-bromomethyl-7-phenoxyacetamido-3-cephem-4-carboxylate-1-oxide.
Claim 15
Dependent Claim
9 words
A compound of claim 1 which is chloromethyldimethylsilyl 3-bromomethyl-7-phenoxyacetamido-3-cephem-4-carboxylate-1-oxide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-30 | 1986-03-01 | 1986-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-30 | 1990-03-01 | 1990-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-30 | 1994-03-01 | 1994-08-31 | $7700.00 | Window Closed / Lapsed |