Patent US3955650A successfully refreshed from Google Patents.
Patent US4346171A successfully refreshed from Google Patents.
US4346171A
Expired / Lapsed
US
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Fermentation process for producing compound having anthelmintic and acaricidal activities
Assignee: Sankyo Co Ltd
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Filing: 1980-08-18
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Granted: 1982-08-24
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Expires: 2000-08-18
Abstract
Abstract A new compound, named "Compound B-41D", has the formula: ##STR1## and can be prepared by cultivating a microorganism of the genus Streptomyces, especially Streptomyces strain B-41-146. Compound B-41D has valuable acaricidal and anthelmintic activities.
Inventors
- 👤 Yo Takiguchi
- 👤 Hiroshi Mishima
- 👤 Shinjiro Yamamoto
- 👤 Michiya Terao
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:52
CPC Classifications
A; A61; A61P; A61P33/00; A61P33/10; C; C07; C07H; C07H19/00; C07H19/01; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P17/00; C12P17/18; C12P17/181; C12R; C12R2001/00; C12R2001/01; C12R2001/465
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
40 words
A process for preparing Compound B-41D having the formula ##STR8## which comprises cultivating Streptomyces strain B-41-146 or a compound B-41D-producing mutant thereof in a culture medium therefor containing skimmed milk to form the Compound B-41D and isolating the Compound B-41D.
Claim 2
Dependent Claim
40 words
A process for preparing Compound B-41D having the formula ##STR8## which comprises cultivating Streptomyces strain B-41-146 or a compound B-41D-producing mutant thereof in a culture medium therefor containing skimmed milk to form the Compound B-41D and isolating the Compound B-41D.
Claim 3
Dependent Claim
26 words
A process as claimed in claim 1, wherein said culture medium comprises, as a source of assimilible carbon, glucose in an amount up to 8% w/v.
Claim 4
Dependent Claim
18 words
A process as claimed in claim 2, wherein said amount of glucose is from 6 to 8% w/v.
Claim 5
Dependent Claim
31 words
A process as claimed in claim 2, wherein said culture medium additionally comprises from 0.5 to 2% w/v of one or more carbon sources selected from lactose, maltose and corn starch.
Claim 6
Dependent Claim
19 words
A process as claimed in claim 1, wherein said culture medium comprises soybean meal as an additional nitrogen source.
Claim 7
Dependent Claim
35 words
A process as claimed in claim 5, wherein the amount of soybean meal is from 0.5 to 1% w/v and the amount of skimmed milk is from 1 to 2% w/v of the culture medium.
Claim 8
Dependent Claim
84 words
A process for the preparation of Compound B-41D of the formula ##STR9## which comprises cultivating Streptomyces strain B-41-146 or a compound B-41D-producing mutant thereof in a culture medium containing from 1 to 2% w/v skimmed milk and further comprising from 6 to 8% w/v glucose; from 0.5 to 2% w/v of one or more carbon sources selected from the group consisting of lactose, maltose and corn starch and from 0.5 to 1% w/v soybeam meal to produce Compound B-41D and isolating said Compound B-41D.
Claim 9
Dependent Claim
84 words
A process for the preparation of Compound B-41D of the formula ##STR9## which comprises cultivating Streptomyces strain B-41-146 or a compound B-41D-producing mutant thereof in a culture medium containing from 1 to 2% w/v skimmed milk and further comprising from 6 to 8% w/v glucose; from 0.5 to 2% w/v of one or more carbon sources selected from the group consisting of lactose, maltose and corn starch and from 0.5 to 1% w/v soybeam meal to produce Compound B-41D and isolating said Compound B-41D.
Claim 10
Dependent Claim
67 words
A process for the preparation of an acaricidal and anthelmintic composition containing Compound B-41D having the formula ##STR10## which process comprises the steps: (a) cultivating Streptomyces strain B-41D compound B-41D-producing mutant thereof in a culture medium therefor containing skimmed milk to produce Compound B-41D; (b) separating an acaricidally and anthelmintically active fraction containing Compound B-41D from the culture medium; and (c) concentrating and isolating said Compound B-41D.
Claim 11
Dependent Claim
67 words
A process for the preparation of an acaricidal and anthelmintic composition containing Compound B-41D having the formula ##STR10## which process comprises the steps: (a) cultivating Streptomyces strain B-41D compound B-41D-producing mutant thereof in a culture medium therefor containing skimmed milk to produce Compound B-41D; (b) separating an acaricidally and anthelmintically active fraction containing Compound B-41D from the culture medium; and (c) concentrating and isolating said Compound B-41D.
Claim 12
Dependent Claim
51 words
A process for preparing Compound B-41D having the formula ##STR11## which comprises cultivating Streptomyces strain B-41-146 or a compound B-41D-producing mutant thereof in a culture medium to produce the compound B-41D together with other compounds, extracting compound B-41D together with other compounds from said culture medium, and isolating said compound B-41D.
Claim 13
Dependent Claim
51 words
A process for preparing Compound B-41D having the formula ##STR11## which comprises cultivating Streptomyces strain B-41-146 or a compound B-41D-producing mutant thereof in a culture medium to produce the compound B-41D together with other compounds, extracting compound B-41D together with other compounds from said culture medium, and isolating said compound B-41D.
Claim 14
Dependent Claim
22 words
The process as claimed in claim 9 wherein the compound B-41D together with other compounds are solvent extracted from said culture medium.
Claim 15
Dependent Claim
20 words
The process as claimed in claim 9 or 10 wherein said compound B-41D is chromatographically isolated from said other compounds.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-23 | 1986-02-22 | 1986-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-23 | 1990-02-22 | 1990-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-23 | 1994-02-22 | 1994-08-24 | $7700.00 | Window Closed / Lapsed |