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US4337272A
Expired / Lapsed
US
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Amino-ethanol derivatives
Assignee: Valeas SpA Industria Chimica e Farmaceutica
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Filing: 1980-10-02
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Granted: 1982-06-29
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Expires: 2000-10-02
Abstract
Abstract New compounds of the formula <IMAGE> (I) are disclosed wherein R1=H, linear or branched alkyl-radical with from 1 to 6 carbon atoms, cycloalkyl radical with from 3 to 6 carbon atoms, alkylphenyl radical where the phenyl group may be in turn substituted with a hydroxy or methoxy group; R2=hydroxy, hydromethyl R3=H, alkyl with 1-4 carbon atoms, formyl, carboalkyl where the alkyl groups have 1-3 carbon atoms, carboamido group simple or mono- or di-substituted on the nitrogen atom with alkyl radicals containing 1-3 carbon atoms. The new compounds are useful in the treatment of bronchial affections. They are endowed with unique properties in that they provide the desired bronchial dilation effect without any concomitant cardiac stimulation.
Inventors
- 👤 Virgilio Bernareggi
- 👤 Giuseppe Crespi
- 👤 Giuseppe Bugada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:40
CPC Classifications
C; C07; C07D; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/22; A; A61; A61P; A61P11/00; A61P11/08; A61P13/00; A61P13/02; A61P15/00; A61P25/00; A61P25/02; C07C; C07C205/00; C07C205/45; C07C205/49; C07C205/57; C07C205/59; C07C205/61; C07C229/00; C07C229/38; C07C275/00; C07C275/28; C07C275/40; C07D303/38; C07D303/40
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
76 words
A compound of the formula ##STR23## wherein R 1 is H or CH 3 and R 2 is selected from the group consisting of H, C 1 -C 4 alkyl, carbo C 1 -C 3 alkyl, and a carboamido group simple or mono- or di-substituted on the nitrogen atom with C 1 -C 3 alkyl, and with the proviso that said compound is not 1-(5-amino-3-hydroxymethyl) phenyl-2-(1-p. methoxy phenyl-2-propylamino)ethanol, and a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
76 words
A compound of the formula ##STR23## wherein R 1 is H or CH 3 and R 2 is selected from the group consisting of H, C 1 -C 4 alkyl, carbo C 1 -C 3 alkyl, and a carboamido group simple or mono- or di-substituted on the nitrogen atom with C 1 -C 3 alkyl, and with the proviso that said compound is not 1-(5-amino-3-hydroxymethyl) phenyl-2-(1-p. methoxy phenyl-2-propylamino)ethanol, and a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
13 words
The compound of claim 1 wherein R 1 and R 2 are H.
Claim 4
Dependent Claim
17 words
The compound of claim 1 wherein R 1 is H and R 2 is CH 3 CO.
Claim 5
Dependent Claim
17 words
The compound of claim 1 wherein R 1 is H and R 2 is NH 2 CO.
Claim 6
Dependent Claim
19 words
The compound of claim 1 wherein R 1 is H and R 2 is C 2 H 5 .
Claim 7
Dependent Claim
18 words
The compound of claim 1 wherein R 1 is CH 3 and R 2 is CH 3 CO.
Claim 8
Dependent Claim
18 words
The compound of claim 1 wherein R 1 is CH 3 and R 2 is NH 2 CO.
Claim 9
Dependent Claim
20 words
The compound of claim 1 wherein R 1 is CH 3 and R 2 is C 2 H 5 .
Claim 10
Dependent Claim
23 words
A therapeutic composition useful as a bronchodilator comprising a bronchodilator effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-28 | 1985-12-28 | 1986-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-28 | 1989-12-28 | 1990-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-28 | 1993-12-28 | 1994-06-29 | $7700.00 | Window Closed / Lapsed |