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US4337272A Expired / Lapsed US ⏱️ 0.0 years remaining

Amino-ethanol derivatives

Assignee: Valeas SpA Industria Chimica e Farmaceutica
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Filing: 1980-10-02
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Granted: 1982-06-29
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Expires: 2000-10-02
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Abstract

Abstract New compounds of the formula <IMAGE> (I) are disclosed wherein R1=H, linear or branched alkyl-radical with from 1 to 6 carbon atoms, cycloalkyl radical with from 3 to 6 carbon atoms, alkylphenyl radical where the phenyl group may be in turn substituted with a hydroxy or methoxy group; R2=hydroxy, hydromethyl R3=H, alkyl with 1-4 carbon atoms, formyl, carboalkyl where the alkyl groups have 1-3 carbon atoms, carboamido group simple or mono- or di-substituted on the nitrogen atom with alkyl radicals containing 1-3 carbon atoms. The new compounds are useful in the treatment of bronchial affections. They are endowed with unique properties in that they provide the desired bronchial dilation effect without any concomitant cardiac stimulation.

Inventors

  • 👤 Virgilio Bernareggi
  • 👤 Giuseppe Crespi
  • 👤 Giuseppe Bugada

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-08 02:29
CPC Classifications
C; C07; C07D; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/22; A; A61; A61P; A61P11/00; A61P11/08; A61P13/00; A61P13/02; A61P15/00; A61P25/00; A61P25/02; C07C; C07C205/00; C07C205/45; C07C205/49; C07C205/57; C07C205/59; C07C205/61; C07C229/00; C07C229/38; C07C275/00; C07C275/28; C07C275/40; C07D303/38; C07D303/40

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 76 words
A compound of the formula ##STR23## wherein R 1 is H or CH 3 and R 2 is selected from the group consisting of H, C 1 -C 4 alkyl, carbo C 1 -C 3 alkyl, and a carboamido group simple or mono- or di-substituted on the nitrogen atom with C 1 -C 3 alkyl, and with the proviso that said compound is not 1-(5-amino-3-hydroxymethyl) phenyl-2-(1-p. methoxy phenyl-2-propylamino)ethanol, and a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim 76 words
A compound of the formula ##STR23## wherein R 1 is H or CH 3 and R 2 is selected from the group consisting of H, C 1 -C 4 alkyl, carbo C 1 -C 3 alkyl, and a carboamido group simple or mono- or di-substituted on the nitrogen atom with C 1 -C 3 alkyl, and with the proviso that said compound is not 1-(5-amino-3-hydroxymethyl) phenyl-2-(1-p. methoxy phenyl-2-propylamino)ethanol, and a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim 13 words
The compound of claim 1 wherein R 1 and R 2 are H.
Claim 4
Dependent Claim 17 words
The compound of claim 1 wherein R 1 is H and R 2 is CH 3 CO.
Claim 5
Dependent Claim 17 words
The compound of claim 1 wherein R 1 is H and R 2 is NH 2 CO.
Claim 6
Dependent Claim 19 words
The compound of claim 1 wherein R 1 is H and R 2 is C 2 H 5 .
Claim 7
Dependent Claim 18 words
The compound of claim 1 wherein R 1 is CH 3 and R 2 is CH 3 CO.
Claim 8
Dependent Claim 18 words
The compound of claim 1 wherein R 1 is CH 3 and R 2 is NH 2 CO.
Claim 9
Dependent Claim 20 words
The compound of claim 1 wherein R 1 is CH 3 and R 2 is C 2 H 5 .
Claim 10
Dependent Claim 23 words
A therapeutic composition useful as a bronchodilator comprising a bronchodilator effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.

References Cited (Backward Citations)

US3917847A Cited
JPS4919214A Cited
US3943173A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1985-06-28 1985-12-28 1986-06-29 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1989-06-28 1989-12-28 1990-06-29 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1993-06-28 1993-12-28 1994-06-29 $7700.00 Window Closed / Lapsed

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