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Patent US4320148A successfully refreshed from Google Patents.
US4320148A
Expired / Lapsed
US
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2-Aminotetralin compounds, pharmaceutical compositions and method of producing central alpha1 agonist activity
Assignee: SmithKline Beecham Corp
•
Filing: 1980-11-24
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Granted: 1982-03-16
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Expires: 2000-11-24
Abstract
Abstract 2-Aminotetralin compounds having 5- and 8- substituents are centrally acting alpha 1 agonists.
Inventors
- 👤 Robert M. DeMarinis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
58 words
A compound of the formula: ##STR4## in which: R 1 and R 2 are each hydrogen or lower alkyl having 1 to 3 carbon atoms; X is methoxy and Y is methylthio, ethylthio, phenylthio, trifluoromethylthio or amino; or Y is methoxy and X is methylthio, ethylthio, phenylthio, trifluoromethylthio or amino; or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
58 words
A compound of the formula: ##STR4## in which: R 1 and R 2 are each hydrogen or lower alkyl having 1 to 3 carbon atoms; X is methoxy and Y is methylthio, ethylthio, phenylthio, trifluoromethylthio or amino; or Y is methoxy and X is methylthio, ethylthio, phenylthio, trifluoromethylthio or amino; or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
10 words
The compound of claim 1 in which X is methoxy.
Claim 4
Dependent Claim
10 words
The compound of claim 2 in which Y is methylthio.
Claim 5
Dependent Claim
26 words
The compound of claim 3 in which R 1 and R 2 are hydrogen, being the compound 1,2,3,4-tetrahydro-8-methoxy-5-(methylthio)-2-naphthalenamine or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
10 words
The compound of claim 4 being the compound 1,2,3,4-tetrahydro-8-methoxy-5-(methylthio)-2-naphthalenamine hydrochloride.
Claim 7
Dependent Claim
27 words
The compound of claim 3 in which R 1 and R 2 are methyl, being the compound 1,2,3,4-tetrahydro-8-methoxy N,N-dimethyl-5-(methylthio)-2-naphthalenamine or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
10 words
The compound of claim 1 in which Y is methoxy.
Claim 9
Dependent Claim
10 words
The compound of claim 7 in which X is methylthio.
Claim 10
Dependent Claim
26 words
The compound of claim 8 in which R 1 and R 2 are hydrogen being the compound 1,2,3,4-tetrahydro-5-methoxy-8-(methylthio)-2-naphthalenamine or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Dependent Claim
27 words
The compound of claim 8 in which R 1 and R 2 are methyl being the compound 1,2,3,4-tetrahydro-5-methoxy N,N-dimethyl-8-(methylthio)-2-naphthalenamine or a pharmaceutically acceptable acid addition salt thereof.
Claim 12
Dependent Claim
28 words
A pharmaceutical composition in dosage unit form having alpha 1 agonist activity comprising a pharmaceutical carrier and an effective amount of a compound as defined in claim 1.
Claim 13
Dependent Claim
28 words
A pharmaceutical composition in dosage unit form having alpha 1 agonist activity comprising a pharmaceutical carrier and an effective amount of the compound as defined in claim 4.
Claim 14
Dependent Claim
28 words
A pharmaceutical composition in dosage unit form having alpha 1 agonist activity comprising a pharmaceutical carrier and an effective amount of the compound as defined in claim 5.
Claim 15
Dependent Claim
33 words
A method of producing alpha 1 agonist activity which comprises administering to an animal requiring said treatment an amount sufficient to produce said activity of a chemical compound as defined in claim 1.
Claim 16
Dependent Claim
33 words
A method of producing alpha 1 agonist activity which comprises administering to an animal requiring said treatment an amount sufficient to produce said activity of a chemical compound as defined in claim 4.
Claim 17
Dependent Claim
38 words
A method of producing alpha 1 agonist activity which comprises administering to an animal requiring said treatment a dosage unit of from about 50 mg. to about 100 mg. of a chemical compound as defined in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-15 | 1985-09-14 | 1986-03-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-15 | 1989-09-14 | 1990-03-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-15 | 1993-09-14 | 1994-03-16 | $7700.00 | Window Closed / Lapsed |