Patent US4318903A successfully refreshed from Google Patents.
US4318903A
Expired / Lapsed
US
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Live influenza virus vaccine and the preparation thereof
Assignee: SmithKline RIT
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Filing: 1978-07-12
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Granted: 1982-03-09
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Expires: 1998-07-12
Abstract
Abstract The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain. The new strain, which is the CNCM I-062 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/Alaska/5/77 virus strain. The vaccine is prepared by allowing the CNCM I-062 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material. The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H 3 N 2 ) virus strains.
Inventors
- 👤 Michele Lobmann
- 👤 Gerard Florent
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 11:34
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/145; A61K2039/51; A61K2039/525; A61K2039/5254; A61K2039/54; A61K2039/541; A61K2039/543; C; C12; C12N; C12N2760/00; C12N2760/00011; C12N2760/16011; C12N2760/16111; C12N2760/16134
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
7 words
The recombinant influenza virus CNCM I-062 strain.
Claim 2
Dependent Claim
7 words
The recombinant influenza virus CNCM I-062 strain.
Claim 3
Dependent Claim
25 words
A live influenza virus vaccine composition comprising an effective dose of the recombinant influenza virus CNCM I-062 strain and a pharmaceutical diluent for nasal administration.
Claim 4
Dependent Claim
25 words
A live influenza virus vaccine composition comprising an effective dose of the recombinant influenza virus CNCM I-062 strain and a pharmaceutical diluent for nasal administration.
Claim 5
Dependent Claim
22 words
A live influenza virus vaccine composition according to claim 2 wherein the effective dose is at least 10 7 EID 50 .
Claim 6
Dependent Claim
65 words
A process of producing a live influenza virus vaccine according to claim 2 which comprises allowing the recombinant influenza virus CNCM I-062 strain to grow in the allantoic cavity of embryonated chicken eggs for a period of time sufficient to permit production of a large amount of said virus, harvesting the resulting virus material and, if desired, adding thereto a stabilizer and freeze-drying the mixture.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-08 | 1985-09-07 | 1986-03-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-08 | 1989-09-07 | 1990-03-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-08 | 1993-09-07 | 1994-03-09 | $7700.00 | Window Closed / Lapsed |