US4314054A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin
Assignee: SRI International Inc
•
Filing: 1981-03-23
•
Granted: 1982-02-02
•
Expires: 2001-03-23
Abstract
Abstract Described are 3'-deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin having the formula <IMAGE> wherein R is COCH3 or -CHOHCH3 in the case of daunorubicin derivatives, or is COCH2OH or -CHOH-CH2OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid salts. The compounds have utility as antitumor agents.
Inventors
- 👤 Edward M. Acton
- 👤 Carol W. Mosher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:55
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
37 words
Compounds of the formula ##STR4## wherein R is selected from the group consisting of --COCH 3 , --CHOHCH 3 , --COCH 2 OH and --CHOHCH 2 OH and the pharmaceutically acceptable acid addition salts of said compounds.
Claim 2
Dependent Claim
37 words
Compounds of the formula ##STR4## wherein R is selected from the group consisting of --COCH 3 , --CHOHCH 3 , --COCH 2 OH and --CHOHCH 2 OH and the pharmaceutically acceptable acid addition salts of said compounds.
Claim 3
Dependent Claim
15 words
The compound of claim 1 which is 3'-deamino-3'-(4-methoxy-1-piperidinyl)daunorubicin and its pharmaceutically acceptable acid addition salts.
Claim 4
Dependent Claim
9 words
The compound of claim 2 which is 3'-deamino-3'-(4-methoxy-1-piperidinyl)daunorubicin hydrochloride.
Claim 5
Dependent Claim
13 words
The compound of claim 1 which is 3'-deamino-3'-(4-methoxy-1-piperidinyl)-13-dihydrodaunorubicin and its pharmaceutically acceptable salt.
Claim 6
Dependent Claim
9 words
The compound of claim 4 which is 3'-deamino-3'-(4-methoxy-1-piperidinyl)-13-dihydrodoxorubicin hydrochloride.
Claim 7
Dependent Claim
15 words
The compound of claim 1 which is 3'-deamino-3'-(4-methoxy-1-piperidinyl)doxorubicin and its pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
15 words
The compound of claim 1 which is 3'-deamino-3'-(4-methoxy-1-piperidinyl)-13-dihydrodoxorubicin and its pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-02-01 | 1985-08-03 | 1986-02-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-02-01 | 1989-08-03 | 1990-02-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-02-01 | 1993-08-03 | 1994-02-02 | $7700.00 | Window Closed / Lapsed |