US4307113A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anthranilic acid derivatives
Assignee: Sandoz Inc
•
Filing: 1980-01-21
•
Granted: 1981-12-22
•
Expires: 2000-01-21
Abstract
Abstract Agents for lowering glucose levels in blood having the formula: <IMAGE> wherein Ro is bromo, chloro, fluoro, nitro or trifluoromethyl, R is hydrogen, C1-6 alkyl or C2-18 alkanoyl, and R1 is hydrogen or C1-12 alkyl, and the non-toxic, pharmaceutically acceptable salts thereof.
Inventors
- 👤 Paul L. Anderson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/235; A61K31/24; A61K31/245; A61K31/185; A61K31/19; A61K31/195
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
82 words
A method of treating diabetes by lowering the glucose levels in blood plasma comprising administering to a diabetic host a therapeutically effective amount of a compound of formula I: ##STR16## wherein R o is bromo, chloro, fluoro, nitro or trifluoromethyl, R is hydrogen, C 1-6 alkyl or C 2-18 alkanoyl, and R 1 is hydrogen or C 1-12 alkyl, or a pharmaceutically acceptable simple or acid addition salt thereof, said therapeutically effective amount being an amount effective for the treatment of diabetes.
Claim 2
Independent Claim
82 words
A method of treating diabetes by lowering the glucose levels in blood plasma comprising administering to a diabetic host a therapeutically effective amount of a compound of formula I: ##STR16## wherein R o is bromo, chloro, fluoro, nitro or trifluoromethyl, R is hydrogen, C 1-6 alkyl or C 2-18 alkanoyl, and R 1 is hydrogen or C 1-12 alkyl, or a pharmaceutically acceptable simple or acid addition salt thereof, said therapeutically effective amount being an amount effective for the treatment of diabetes.
Claim 3
Dependent Claim
63 words
A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula I wherein R o is as defined in claim 1; R is hydrogen, C 1-6 alkyl or C 2-4 alkanoyl; and R 1 is hydrogen or C 1-6 alkyl, or a pharmaceutically acceptable simple or acid addition salt thereof.
Claim 4
Dependent Claim
41 words
A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula Ia: ##STR17## wherein R o is as defined in claim 1, or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
41 words
A method of treating diabetes according to claim 3 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4- or 6-position, or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
39 words
A method of treating diabetes according to claim 4 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4-position, or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
32 words
A method of treating diabetes according to claim 5 comprising administering to a diabetic host a therapeutically effective amount of the compound of the formula, ##STR18## or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
50 words
A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula Ib: ##STR19## wherein R o is as defined in claim 1 and R 1 is C 1-12 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Dependent Claim
50 words
A method of treating diabetes according to claim 7 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4- or 6-position and R 1 is C 1-8 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
48 words
A method of treating diabetes according to claim 8 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4-position and R 1 is C 1-6 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Dependent Claim
34 words
A method of treating diabetes according to claim 9 comprising administering to a diabetic host a therapeutically effective amount of the compound of the formula, ##STR20## or a pharmaceutically acceptable acid addition salt thereof.
Claim 12
Dependent Claim
46 words
A method of treating diabetes according to claim 7 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is as defined in claim 7 and R 1 is C 1-6 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 13
Dependent Claim
48 words
A method of treating diabetes according to claim 11 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4-position and R 1 is C 1-4 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 14
Dependent Claim
45 words
A method of treating diabetes according to claim 12 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is trifluoromethyl in the 4-position and R 1 is methyl or ethyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 15
Dependent Claim
51 words
A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula Ic: ##STR21## wherein R o is as defined in claim 1 and R is C 2-18 alkanoyl or C 1-6 alkyl, or a pharmaceutically acceptable salt thereof.
Claim 16
Dependent Claim
48 words
A method of treating diabetes according to claim 14 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4- or 6-position and R is C 2-18 alkanoyl, or a pharmaceutically acceptable simple salt thereof.
Claim 17
Dependent Claim
45 words
A method of treating diabetes according to claim 15 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is trifluoromethyl in the 4- or 6-position and R is C 2-18 alkanoyl, or a pharmaceutically acceptable simple salt thereof.
Claim 18
Dependent Claim
48 words
A method of treating diabetes according to claim 14 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4- or 6-position and R is C 2-12 alkanoyl, or a pharmaceutically acceptable simple salt thereof.
Claim 19
Dependent Claim
46 words
A method of treating diabetes according to claim 17 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4-position and R is C 2-8 -alkanoyl, or a pharmaceutically acceptable simple salt thereof.
Claim 20
Dependent Claim
33 words
A method of treating diabetes according to claim 18 comprising administering to a diabetic host a therapeutically effective amount of a compound of the formula, ##STR22## or a pharmaceutically acceptable simple salt thereof.
Claim 21
Dependent Claim
33 words
A method of treating diabetes according to claim 18 comprising administering to a diabetic host a therapeutically effective amount of the compound of the formula, ##STR23## or a pharmaceutically acceptable simple salt thereof.
Claim 22
Dependent Claim
47 words
A method of treating diabetes according to claim 14 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is as defined in claim 14 and R is C 2-4 alkanoyl or C 1-6 alkyl, or a pharmaceutically acceptable salt thereof.
Claim 23
Dependent Claim
46 words
A method of treating diabetes according to claim 21 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4-position and R is C 2-4 alkanoyl, or a pharmaceutically acceptable simple salt thereof.
Claim 24
Dependent Claim
42 words
A method of treating diabetes according to claim 22 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is as defined in claim 22 and R is acetyl, or a pharmaceutically acceptable simple salt thereof.
Claim 25
Dependent Claim
59 words
A method of treating diabetes according to claim 1 comprising administering to a diabetic host a therapeutically effective amount of a compound of formula Id: ##STR24## wherein R o is as defined in claim 1, R is C 2-18 alkanoyl or C 1-6 alkyl and R 1 is C 1-12 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 26
Dependent Claim
47 words
A method of treating diabetes according to claim 24 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4- or 6-position, R is C 2-12 alkanoyl and R 1 is C 1-8 alkyl.
Claim 27
Dependent Claim
45 words
A method of treating diabetes according to claim 25 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is chloro, nitro or trifluoromethyl in the 4-position, R is C 2-8 alkanoyl and R 1 is C 1-6 alkyl.
Claim 28
Dependent Claim
55 words
A method of treating diabetes according to claim 24 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is as defined in claim 24, R is C 2-4 alkanoyl or C 1-6 alkyl and R 1 is C 1-6 alkyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 29
Dependent Claim
43 words
A method of treating diabetes according to claim 27 comprising administering to a diabetic host a therapeutically effective amount of a compound wherein R o is as defined in claim 27, R is C 2-4 alkanoyl and R 1 is C 1-6 alkyl.
References Cited (Backward Citations)
US3268394A
Cited
US3422200A
Cited
US3657436A
Cited
US3869553A
Cited
US3868416A
Cited
FR2258367A1
Cited
US4143151A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-21 | 1985-06-22 | 1985-12-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-21 | 1989-06-22 | 1989-12-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-21 | 1993-06-22 | 1993-12-22 | $7700.00 | Window Closed / Lapsed |