US4306556A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for storing and preparing cryopreserved blood
Assignee: Rensselaer Polytechnic Institute
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Filing: 1980-02-07
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Granted: 1981-12-22
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Expires: 2000-02-07
Abstract
Abstract A bag for containing blood or blood components comprising a closed container made of material which is permeable to a cryoprotective agent, such as glycerol, which may be added to the blood or blood components directly through the permeable walls of the blood bag. The cryoprotective agent protects the blood or blood components when the blood is frozen for storage and the cryoprotective agent can thereafter be removed through the permeable walls of the container without contaminating the blood therein. An apparatus and process is also disclosed for the cryoprotective agent to be added or removed from the blood bag using electric current, hydrostatic pressure, centrifugal force or osmosis.
Inventors
- 👤 Allen Zelman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:49
CPC Classifications
A; A61; A61J; A61J1/00; A61J1/14; A61J1/20; A01; A01N; A01N1/00; A01N1/10; A01N1/14; A01N1/146; A01N1/147; A61L; A61L33/00; A61L33/06; A61J1/05; A61J1/10
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
84 words
A bag for containing a mixture of blood or blood components and a cryoprotective agent and, in particular red blood cells, comprising a container having at least one port for the entry and exit of blood or blood components and at least one semi-permeable wall portion which is permeable to the cryoprotective agent whereby the cryoprotective agent can be added to or removed from the container through the wall portion, the wall portion being made of dialysis membrane of the type used in hemodialysis.
Claim 2
Dependent Claim
84 words
A bag for containing a mixture of blood or blood components and a cryoprotective agent and, in particular red blood cells, comprising a container having at least one port for the entry and exit of blood or blood components and at least one semi-permeable wall portion which is permeable to the cryoprotective agent whereby the cryoprotective agent can be added to or removed from the container through the wall portion, the wall portion being made of dialysis membrane of the type used in hemodialysis.
Claim 3
Dependent Claim
23 words
A bag for containing blood or blood components according to claim 1, wherein said at least one wall portion comprises the entire container.
Claim 4
Dependent Claim
27 words
A bag for containing blood or blood components according to claim 1, further including reinforcing strands associated with said at least one wall portion to strengthen it.
Claim 5
Dependent Claim
23 words
A bag for containing blood or blood components according to claim 1, wherein said at least one wall portion comprises a polycarbonate membrane.
Claim 6
Dependent Claim
20 words
A bag for containing blood or blood components according to claim 4, further including reinforcing strands associated with said membrane.
Claim 7
Dependent Claim
21 words
A bag for containing blood or blood components according to claim 1, further including reinforcing strands extending through said electro-osmosis membrane.
Claim 8
Dependent Claim
24 words
A bag for containing blood or blood components according to claim 1, further including a removable outer water-impervious plastic bag around said closed container.
Claim 9
Dependent Claim
126 words
A bag for containing a mixture of blood or blood components and a cryoprotective agent and, in particular, red blood cells, comprising a container having at least one port for the entry and exit of blood or blood components and at least one semi-permeable wall portion which is permeable to the cryoprotective agent and whereby the cryoprotective agent can be added to or removed from the container through the wall portion, an electro-osmosis membrane connected to an exterior of at least one wall portion whereby the cryoprotective agent can be added to or removed from the closed container through said at least one wall portion and said electro-osmosis membrane by the passage of an electric current through said at least one wall portion and electro-osmosis membrane.
Claim 10
Dependent Claim
126 words
A bag for containing a mixture of blood or blood components and a cryoprotective agent and, in particular, red blood cells, comprising a container having at least one port for the entry and exit of blood or blood components and at least one semi-permeable wall portion which is permeable to the cryoprotective agent and whereby the cryoprotective agent can be added to or removed from the container through the wall portion, an electro-osmosis membrane connected to an exterior of at least one wall portion whereby the cryoprotective agent can be added to or removed from the closed container through said at least one wall portion and said electro-osmosis membrane by the passage of an electric current through said at least one wall portion and electro-osmosis membrane.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-21 | 1985-06-22 | 1985-12-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-21 | 1989-06-22 | 1989-12-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-21 | 1993-06-22 | 1993-12-22 | $7700.00 | Window Closed / Lapsed |