US4132594A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Gas diffusion liquid storage bag and method of use for storing blood
Assignee: National Aeronautics and Space Administration
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Filing: 1976-06-28
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Granted: 1979-01-02
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Expires: 1996-06-28
Abstract
Abstract It has been found that the shelf life of stored whole blood may be doubled by adding a buffer which maintains a desired pH level. However, this buffer causes the generation of CO 2 which, if not removed at a controlled rate, causes the pH value of the blood to decrease, which shortens the useful life of the blood. This invention provides a blood storage bag which permits the CO 2 to be diffused out at a controlled rate into the atmosphere, thereby maintaining the desired pH value while providing a bag strong enough to permit handling thereof.
Inventors
- 👤 Herman Bank
- 👤 Edward L. Cleland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:00
CPC Classifications
A; A61; A61J; A61J1/00; A61J1/05; A61J1/10; A61M; A61M1/00; A61M1/36; A61M1/3687
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
121 words
A method of storing blood which has been treated with a selected compound to extend the useful life of the blood, said treatment resulting in the subsequent production of CO 2 , the method comprising the steps of: providing a closeable plastic bag adapted to contain a preselected quantity of treated blood, the bag having first wall portions of a thickness chosen to enable CO 2 to diffuse through said portions at a selected predetermined rate so as to maintain the pH of said treated blood within a selected range, said bag having second wall portions for providing strength for said bag to withstand pressure applied thereto at least by the stored blood; and storing the treated blood in said bag.
Claim 2
Independent Claim
121 words
A method of storing blood which has been treated with a selected compound to extend the useful life of the blood, said treatment resulting in the subsequent production of CO 2 , the method comprising the steps of: providing a closeable plastic bag adapted to contain a preselected quantity of treated blood, the bag having first wall portions of a thickness chosen to enable CO 2 to diffuse through said portions at a selected predetermined rate so as to maintain the pH of said treated blood within a selected range, said bag having second wall portions for providing strength for said bag to withstand pressure applied thereto at least by the stored blood; and storing the treated blood in said bag.
Claim 3
Independent Claim
169 words
A system for the storage of a liquid within a closed bag wherein a predetermined gas is formed, and for controlling a selected characteristic of said liquid, which is related to the content of said gas in said bag, said system comprising: a bag having semi-permeable wall means including thin wall means of preselected thickness for enabling said gas to diffuse through said thin wall means at a selected rate, to thereby control the selected characteristic of said liquid, said wall means including reinforcing means for enabling said bag to withstand pressure, wherein said reinforcing means comprises a spaced ribbing of the same material as the material of said thin wall means and which is integral therewith and of a thickness sufficient to reinforce said bag and the ratio of the surface area of said thin wall means to the total surface area of said bag is preselected to control the characteristic of said liquid by controlling the rate of diffusion of said gas through said thin wall means.
Claim 4
Independent Claim
169 words
A system for the storage of a liquid within a closed bag wherein a predetermined gas is formed, and for controlling a selected characteristic of said liquid, which is related to the content of said gas in said bag, said system comprising: a bag having semi-permeable wall means including thin wall means of preselected thickness for enabling said gas to diffuse through said thin wall means at a selected rate, to thereby control the selected characteristic of said liquid, said wall means including reinforcing means for enabling said bag to withstand pressure, wherein said reinforcing means comprises a spaced ribbing of the same material as the material of said thin wall means and which is integral therewith and of a thickness sufficient to reinforce said bag and the ratio of the surface area of said thin wall means to the total surface area of said bag is preselected to control the characteristic of said liquid by controlling the rate of diffusion of said gas through said thin wall means.
Claim 5
Dependent Claim
18 words
A system as recited in claim 2 wherein said reinforcing means are in excess of 50 mils thick.
Claim 6
Dependent Claim
32 words
A system as recited in claim 3 wherein the surface area that said thin wall means occupies is on the order of 50% of the total surface area of said wall means.
Claim 7
Independent Claim
171 words
A system for storing whole blood or red blood cells which has been treated to extend its usable life, which treatment results in the production of CO 2 and requires the removal of CO 2 at a predetermined rate, so as to maintain the pH of the blood or the red blood cells within a selected range, said system comprising: a bag having semi-permeable wall means including thin wall means of preselected thickness for enabling CO 2 to diffuse through said wall means at a selected rate, said wall means including reinforcing means juxtaposed with said thin wall means for enabling said bag to withstand pressure, the ratio of the surface area of said thin wall means, which do not include said reinforcing means, to the total surface area of said wall means being selected to control the rate of diffusion of the CO 2 through said thin wall means so that the pH of the blood or the red blood cells in said bag is maintained within said selected range.
Claim 8
Independent Claim
171 words
A system for storing whole blood or red blood cells which has been treated to extend its usable life, which treatment results in the production of CO 2 and requires the removal of CO 2 at a predetermined rate, so as to maintain the pH of the blood or the red blood cells within a selected range, said system comprising: a bag having semi-permeable wall means including thin wall means of preselected thickness for enabling CO 2 to diffuse through said wall means at a selected rate, said wall means including reinforcing means juxtaposed with said thin wall means for enabling said bag to withstand pressure, the ratio of the surface area of said thin wall means, which do not include said reinforcing means, to the total surface area of said wall means being selected to control the rate of diffusion of the CO 2 through said thin wall means so that the pH of the blood or the red blood cells in said bag is maintained within said selected range.
Claim 9
Dependent Claim
71 words
A system as recited in claim 5 wherein said thin wall means of said bag form a first closed bag and said reinforcing means of said bag constitute a second open mesh bag into which said first bag is inserted, said second open mesh bag being made of elastic material and being sized to apply pressure to said first bag when it is filled with said blood or red blood cells.
Claim 10
Dependent Claim
32 words
A system as described in claim 5 wherein the surface area that said thin wall means occupies is on the order of 50% of the total surface area of said wall means.
Claim 11
Dependent Claim
25 words
A system as recited in claim 5 wherein said reinforcing means comprises a mesh of material embedded in the surface of said thin wall means.
Claim 12
Dependent Claim
14 words
A system as recited in claim 8 wherein said mesh of material is nylon.
Claim 13
Dependent Claim
16 words
A system as recited in claim 8 wherein said mesh of material is a metallic foil.
Claim 14
Dependent Claim
20 words
A system as described in claim 5 wherein at least said thin wall means are made of medical grade material.
Claim 15
Dependent Claim
51 words
A system as described in claim 11 wherein said thin wall means and said reinforcing means are of the same material with the thickness of said thin wall means being on the order of 1 to 6 mils and the thickness of said reinforcing means being not less than 50 mils.
Claim 16
Dependent Claim
32 words
A system as described in claim 12 wherein the surface area that said thin wall means occupies is on the order of 50% of the total surface area of said wall means.
Claim 17
Dependent Claim
24 words
A system as described in claim 11 wherein the thickness of said thin wall means is on the order of 1 to 6 mils.
Claim 18
Dependent Claim
32 words
A system as described in claim 14 wherein the surface area that said thin wall means occupies is on the order of 50% of the total surface area of said wall means.
Claim 19
Dependent Claim
18 words
A system as described in claim 14 wherein said reinforcing means are in excess of 50 mils thick.
Claim 20
Dependent Claim
32 words
A system as described in claim 16 wherein the surface area that said thin wall means occupies is on the order of 50% of the total surface area of said wall means.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-01 | 1982-07-03 | 1983-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-01 | 1986-07-03 | 1987-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-01 | 1990-07-03 | 1991-01-02 | $7700.00 | Window Closed / Lapsed |