Patent US4298591A successfully refreshed from Google Patents.
US4298591A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor
Assignee: United States Department of Energy
•
Filing: 1979-04-03
•
Granted: 1981-11-03
•
Expires: 1999-04-03
Abstract
Abstract The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free 125I- is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.
Inventors
- 👤 Harold A. O'Brien, Jr.
- 👤 Homer B. Hupf
- 👤 Philip M. Wanek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:28
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/58; G01N33/60; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/041; A61K51/0412; A61K51/0421; A61K2123/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
59 words
A method for radioiodinating rose bengal comprising the steps of: placing rose bengal and a suitable oxidizing agent in acidified ethanol; stirring the solution resulting until it forms a uniform suspension; adding an iodide in which the iodine moiety is radioactive; and allowing the resulting mixture to stand for a time sufficient for the exchange label reaction to occur.
Claim 2
Independent Claim
59 words
A method for radioiodinating rose bengal comprising the steps of: placing rose bengal and a suitable oxidizing agent in acidified ethanol; stirring the solution resulting until it forms a uniform suspension; adding an iodide in which the iodine moiety is radioactive; and allowing the resulting mixture to stand for a time sufficient for the exchange label reaction to occur.
Claim 3
Dependent Claim
15 words
The invention of claim 1 wherein the iodine moiety used comprises 123 I - .
Claim 4
Dependent Claim
15 words
The invention of claim 1 wherein the iodine moiety used comprises -125 I - .
Claim 5
Dependent Claim
15 words
The invention of claim 1 wherein the iodine moiety used comprises -131 I - .
Claim 6
Dependent Claim
11 words
The invention of claim 1 wherein the iodide is reductant free.
Claim 7
Dependent Claim
13 words
The invention of claim 1 wherein the oxidizing agent comprises KIO 3 .
Claim 8
Dependent Claim
30 words
The invention of claim 1 further comprising, after the exchange label reaction occurs, adding a solution of sterile isotonic phosphate buffer and sodium hydroxide and terminally sterilizing the resulting mixture.
Claim 9
Dependent Claim
13 words
The invention of claim 7 wherein terminal sterilization is accomplished by membrane filtration.
Claim 10
Dependent Claim
24 words
The invention of claim 7 wherein the pH of the sterile isotonic phophate buffer and sodium hydroxide is between about 6.9 and about 7.5.
Claim 11
Dependent Claim
18 words
The invention of claim 1 wherein the label exchange mixture standing time is at least about fifteen minutes.
Claim 12
Dependent Claim
59 words
A cold kit for radioiodinating rose bengal at room temperature comprising: a packaged composition of purified rose bengal and KIO 3 , and a stirring bar contained in a sterilized, sealed serum vial; a separately packaged solution of acidified ethanol; and a separately packaged measured solution of sterile phosphate buffer and sodium hydroxide solution in a sealed serum vial.
Claim 13
Dependent Claim
59 words
A cold kit for radioiodinating rose bengal at room temperature comprising: a packaged composition of purified rose bengal and KIO 3 , and a stirring bar contained in a sterilized, sealed serum vial; a separately packaged solution of acidified ethanol; and a separately packaged measured solution of sterile phosphate buffer and sodium hydroxide solution in a sealed serum vial.
Claim 14
Dependent Claim
17 words
The invention of claim 11 wherein said stirring bar comprises a tetrafluoroethylene polymer coated magnetic stirring bar.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-02 | 1985-05-04 | 1985-11-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-02 | 1989-05-04 | 1989-11-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-02 | 1993-05-04 | 1993-11-03 | $7700.00 | Window Closed / Lapsed |