US4028389A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Metallocenes and metallocene derivatives having a radioactive central atom
Assignee: Bayer Pharma AG
•
Filing: 1973-09-21
•
Granted: 1977-06-07
•
Expires: 1993-09-21
Abstract
Abstract Radioactive metallocenes and metallocene derivatives are prepared by heating a non-radioactive metallocene or metallocene derivative with a radioactive metal salt, e.g., Ru 103 Cl 3 , at 140°-250° C.
Inventors
- 👤 Martin Wenzel
- 👤 Detlef Langheim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 20:35
CPC Classifications
C; C07; C07F; C07F17/00; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0487
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
110 words
A process for the production of metallocenes or metallocene derivatives with a radioactive central atom, which comprises heating at 150°-200° C. for 0.1-3 hours a non-radioactive metallocene or metallocene bearing a substituent selected from the group consisting of --COOH, --COO-alkyl, CONH 2 , alkanoyl, halogen, amino or dialkylamino wherein alkyl and alkanoyl in each instance are of 1-8 carbon atoms on at least one cyclopentadienyl radical, with a radioactive metal nuclide selected from Group VIII and Subgroups VI and VII of the Periodic Table which is capable for forming a metallocene in ionic form and thereafter separating the thus-obtained radioactive metallocene or metallocene derivative from the ionic radioactive starting material.
Claim 2
Dependent Claim
110 words
A process for the production of metallocenes or metallocene derivatives with a radioactive central atom, which comprises heating at 150°-200° C. for 0.1-3 hours a non-radioactive metallocene or metallocene bearing a substituent selected from the group consisting of --COOH, --COO-alkyl, CONH 2 , alkanoyl, halogen, amino or dialkylamino wherein alkyl and alkanoyl in each instance are of 1-8 carbon atoms on at least one cyclopentadienyl radical, with a radioactive metal nuclide selected from Group VIII and Subgroups VI and VII of the Periodic Table which is capable for forming a metallocene in ionic form and thereafter separating the thus-obtained radioactive metallocene or metallocene derivative from the ionic radioactive starting material.
Claim 3
Dependent Claim
41 words
A process according to claim 1 wherein at least one cyclopentadienyl radical of the starting metallocene is substituted by --COOH, --COO-alkyl, COHN 2 , alkanoyl, halogen, amino or dialkylamino wherein alkyl and alkanoyl in each instance are of 1-8 carbon atoms.
Claim 4
Dependent Claim
12 words
A process according to claim 2 wherein the metallocene is a ferrocene.
Claim 5
Dependent Claim
37 words
A process according to claim 3 wherein the non-radioactive starting metallocene is selected from the group consisting of ferrocene, ferrocene monocarboxylic acid, ferrocene monocarboxylic acid amide, methyl ester of ferrocene monocarboxylic acid, ferrocene monoacetyl and ferrocene diacetyl.
Claim 6
Dependent Claim
22 words
A process according to claim 1 wherein the radioactive ionic starting material is a metal of Subgroup VIII of the periodic table.
Claim 7
Dependent Claim
17 words
A process according to claim 5 wherein the ionic radioactive starting material is ionic iron or ruthenium.
Claim 8
Dependent Claim
24 words
A process according to claim 6 wherein the radioactive ionic starting material is a water soluble iron or ruthenium salt of a strong acid.
Claim 9
Dependent Claim
14 words
A process according to claim 7 wherein the salt is a Ru 103 salt.
Claim 10
Dependent Claim
15 words
A process according to claim 8 wherein the salt is Ru 103 Cl 3 .
Claim 11
Dependent Claim
37 words
A process according to claim 7 wherein the non-radioactive starting metallocene is selected from the group consisting of ferrocene, ferrocene monocarboxylic acid, ferrocene monocarboxylic acid amide, methyl ester of ferrocene monocarboxylic acid, ferrocene monoacetyl and ferrocene diacetyl.
Claim 12
Dependent Claim
14 words
A process according to claim 10 wherein the salt is a Ru 103 salt.
Claim 13
Dependent Claim
6 words
Ru 103 -Ruthenocene Monocarboxylic Acid Amide.
Claim 14
Dependent Claim
6 words
Ru 103 -Ruthenocene Monocarboxylic Acid Amide.
Claim 15
Dependent Claim
6 words
Ru 103 -Ruthenocene-Monocarboxylic Acid Methyl Ester.
Claim 16
Dependent Claim
6 words
Ru 103 -Ruthenocene-Monocarboxylic Acid Methyl Ester.
Claim 17
Dependent Claim
58 words
A process according to claim 1 wherein the starting non-radioactive metallocene is ferrocene monocarboxylic acid methyl ester or ferrocene monocarboxylic acid amide, the radioactive metal in ionic form is a Ru 103 salt of a strong acid and the reaction is conducted in the absence of solvent with the salt in intimate physical mixture with the starting metallocene.
References Cited (Backward Citations)
CA706905A
Cited
US3045119A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-06 | 1980-12-06 | 1981-06-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-06 | 1984-12-06 | 1985-06-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-06 | 1988-12-06 | 1989-06-07 | $7700.00 | Window Closed / Lapsed |