Aminobenzoic acid derivatives

Abstract

Abstract The object of the present invention are novel aminobenzoic acid derivatives having the general formula: ##STR1## wherein R 1 is hydrogen, chlorine, hydroxy, acetoxy or C 1 -C 3 -alkoxy; R 2 is hydrogen, chlorine or sulfamoyl; R 5 is hydrogen or combined with R 6 a C 2 -C 3 -alkylene; Y is the group ##STR2## or in ortho-position together with the hydrogen atom on the nitrogen and with R 5 the group ##STR3## wherein R 3 is hydrogen or methyl; R 4 is hydrogen, C 1 -C 3 -alkyl, or with Z substituted phenoxy; and Z is hydrogen, halogen or trifluoromethyl; X is C 1 -C 3 -alkylene forming, if necessary, under substitution with R 6 a 5- or 6-link aliphatic or aromatic ring system; R 6 is C 1 -C 4 -alkyl or in combination with X a C 3 -C 4 -cycloalkylene or cycloarylene; R 7 is hydrogen, C 1 -C 3 -alkyl, formyl, the group Y, or together with R 6 a C 4 -C 5 -cycloalkylene, or together with X and R 6 pyridylmethyl; R 8 is hydrogen or, if necessary, halogen- or phenyl-substituted C 1 -C 4 -alkyl or C 1 -C 4 -alkenyl; and n has the value 0 or 1, and if n=1, their salts with pharmaceutically compatible acid radicals. Said compounds show antilipemic activity. The present invention relates furthermore to the preparation of said compounds and of drugs containing such compounds.

Inventors

• 👤 Gunter Metz
• 👤 Manfred Specker

Bibliographic Details