4,4'-disubstituted-bis(benzamides)

Abstract

Abstract 1. A COMPOUND OF THE FORMULA Q-O-(R2,R3-1,4-PHENYLENE)-CO-N(-R)-Y-N(-R'')-CO-(R4,R5-1,4- PHENYLENE)-R1 -(OXIRAN-2,3-YLENE)- OR Y REPRESENTS Y''-Z-Y'''' WHERE Y'' IS ALKYLENE HAVING FROM ONE TO FOUR CARBON ATOMS INCLUSIVE, Y'''' IS A DIRECT LINKAGE OR ALKYLENE HAVING FROM ONE TO FOUR CARBON ATOMS INCLUSIVE, AND Z IS PHENYLENE OR CYCLOALKYENE HAVING FROM THREE TO SIX RING-CARBON ATOMS INCLUSIVE, PROVIDED WHERE THE TWO BENZOYL MOIETIES ARE DIFFERENT Y HAS NO INTERRUPTING LINKAGE AND HAS AT LEAST ONE CH2 ADJACENT TO ONE N. WHEREIN Q IS (A) LOWER ALKOXYALKYL, MONOHALO-LOWER-ALKYL, POLYHALO-LOWER-ALKYL HAVING 2 TO 5 HALO SUBSTITUENTS, MONOHALO-LOWER-ALKENYL, POLYHALO-LOWER-ALKENYL HAVING 2 TO 3 HALO SUBSTITUENTS OR LOWER CYCLOALKYL ONLY WHERE R2 AND R3 ARE EACH HYDROGEN; (B) PHENYL ONLY WHERE R2 AND R3 ARE EACH HYDROGEN OR HYDROXY; (C) LOWER ALKENYL OR BN-(LOWER-ALKYL), ONLY WHEN R2 AND R3 ARE EACH HYDROGEN, LOWER ALKYL, LOWER ALKOXY OR HALO, AND WHERE BN IS DI(LOWER-ALKYL)AMINO OR A SATURATED NHETERMONOCYCLIC RADICAL HAVING FROM FIVE TO SEVEN RING ATOMS SELECTED FROM PYRROLIDINO, PIPERIDINO, MORPHOLINO, HEXAMETHYLENEIMINO, PIPERAZINO OR SAID HETEROCYCLIC RADICAL SUBSTITUTED BY FROM ONE TO THREE LOWERALKYL RADICALS, R2 AND R3 ARE EACH HYDROGEN, LOWER ALKYL, LOWER ALKOXY, OR HALO, R AND R'' ARE EACH HYDROGEN, LOWER-ALKYL, LOWER-HYDROXYALKYL OR PHENYL, R1 IS (A) Q-O-WHERE Q IS DEFINED AS ABOVE, AND R4 AND R5 ARE DEFINED AS R2 AND R3 ABOVE; (B) HYDROGEN ONLY WHERE R4 AND R5 ARE EACH AS DEFINED BELOW EXCLUDING HYDROXY; (C) HYDROXY ONLY WHERE R4 AND R5 ARE EACH DEFINED BELOW EXCLUDING HYDROXY AND BENZYLOXY; (D) DI(LOWER-ALKYL) AMINO ONLY WHERE R4 AND R5 ARE EACH HYDROGEN, LOWER ALKOXY OR HALO; (E) NITRO ONLY WHERE R4 AND R5 ARE EACH HYDROGEN; OR (F) LOWER ALKOXY, LOWER ALKYL, HALO, BENZYLOXY, AMINO OR TRIHALOMETHYL, R4 AND R5 ARE EACH HYDROGEN; OR LOWER-ALKYL, LOWER-ALKOXY, HALO, BENZYLOXY OR HYDROXY, EXCEPT AS OTHERWISE INDICATED ABOVE IN THE DEFINITION OF R1, AND Y IS ALKYLENE HAVING FROM FIVE TO TWELVE CARBON ATOSOMS INCLUSIVE AND HAVING AT LEAST FIVE CARBON ATOMS BETWEEN ITS TWO CONNECTING LINKAGES OR INTERRUPTED-ALKYLENE HAVING FROM FOUR TO ELEVEN CARBON ATOMS INCLUSIVE WITH AT LEAST FOUR CARBON ATOMS BETWEEN ITS CONNECTING LINKAGES AND HAVING A SINGLE INTERRUPTING LINKAGE LOCATED AT LEAST TWO CARBON ATOMS REMOVED FROM THE AMIDE NITROGEN ATOMS, SAID INTERRUPTING LINKAGE SELECTED FROM -O-, -S-, -S-S-, -SE-SE-, =SO, =SO2, =NH =N(LOWER-ALKYL), =C=O, -CH=CH-, -C$C-, =N(CO-PHENYL-4-O-Q) OR

Inventors

• 👤 G Lesher

Bibliographic Details