US4070485A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Alkoxy anilides process for preparing the same and pharmaceutical compositions
Assignee: Science Union et Cie
•
Filing: 1976-09-16
•
Granted: 1978-01-24
•
Expires: 1996-09-16
Abstract
Abstract This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers. This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof. The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.
Inventors
- 👤 Charles Malen
- 👤 Pierre Roger
- 👤 Jean-Claude Poignant
- 👤 Xavier Pascaud
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 07:34
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/14; C07D295/145; C07D295/15; C07D207/00; C07D207/02; C07D207/04; C07D207/08; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/18; C07D211/34; C07D211/36; C07D211/60
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
179 words
The ortho-alkoxy-anilides of the formula ##STR14## in which n is zero or an integer from one to three, R represents a hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms, R 1 represents a lower alkyl radical of 1 to 6 carbon atoms, a lower alkenyl radical of 2 to 6 carbon atoms, or a phenyl-lower alkyl radical of 1 to 4 carbon atoms in the side chain, R 2 represents a lower alkoxy radical of 1 to 6 carbon atoms or a halogen atom, R 3 represents a hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms, R 4 represents a hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms, X and Y, which may be the same or different, each represents a lower alkyl radical of 1 to 6 carbon atoms. A and B are the same, and each represents a hydrogen atom, or A and B are each an oxygen atom and (b) the acid addition salts thereof with a mineral or organic acid.
Claim 2
Dependent Claim
179 words
The ortho-alkoxy-anilides of the formula ##STR14## in which n is zero or an integer from one to three, R represents a hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms, R 1 represents a lower alkyl radical of 1 to 6 carbon atoms, a lower alkenyl radical of 2 to 6 carbon atoms, or a phenyl-lower alkyl radical of 1 to 4 carbon atoms in the side chain, R 2 represents a lower alkoxy radical of 1 to 6 carbon atoms or a halogen atom, R 3 represents a hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms, R 4 represents a hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms, X and Y, which may be the same or different, each represents a lower alkyl radical of 1 to 6 carbon atoms. A and B are the same, and each represents a hydrogen atom, or A and B are each an oxygen atom and (b) the acid addition salts thereof with a mineral or organic acid.
Claim 3
Dependent Claim
7 words
1-(β-N,N-diethylamino-propionylamino)2-methoxy--4-nitro-5-chloro-benzene being a compound of claim 1.
Claim 4
Dependent Claim
7 words
1-(βN,N-diethylamino-propionylamino)-2-methoxy-4-amino-5-chloro-benzene being a compound of claim 1.
Claim 5
Dependent Claim
6 words
1-(β-diisopropylaminopropionylamino)-2-methoxy-4-amino-5-chlorobenzene, a compound of claim 1.
Claim 6
Dependent Claim
28 words
A pharmaceutical composition intended for gastroenteric therapy comprising as active ingredients, at least one compound of claim 1, in admixture or conjunction with an inert non-toxic pharmaceutical carrier.
Claim 7
Dependent Claim
39 words
A method of inhibiting gastric hypersecretion and relieving delay in gastric evacuation which comprises administering to warm blooded animals suffering or disposed to suffer from said ailments a small but inhibitorily effective amount of a compound of claim 1.
Claim 8
Dependent Claim
19 words
The method of claim 6 wherein the small but effective amount ranges from 0.5 mg/kg to 6.6 mg/kg bodyweight.
Claim 9
Dependent Claim
15 words
The method of claim 6 wherein the compound of claim 1 is 1-(β-diethylamino propionylamino) 2-methoxy-4-amino5-chlorobenzene.
References Cited (Backward Citations)
US2851393A
Cited
US2904586A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-23 | 1981-07-25 | 1982-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-23 | 1985-07-25 | 1986-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-23 | 1989-07-25 | 1990-01-24 | $7700.00 | Window Closed / Lapsed |