US4293561A
Expired / Lapsed
US
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1-(Naphthyl-n-propyl)imidazole derivatives
Assignee: Syntex USA LLC
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Filing: 1979-03-09
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Granted: 1981-10-06
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Expires: 1999-03-09
Abstract
Abstract Compounds of the formula <IMAGE> (I) wherein Z is C1 and C4 alkoxymethylene, hydroxymethylene, esterified hydroxymethylene, carbonyl, or ketal-protected carbonyl, and the pharmaceutically acceptable acid addition salts thereof, are useful as anticonvulsant and anti-secretory agents.
Inventors
- 👤 Keith A. M. Walker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 14:59
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/10; C07D231/12; A; A61; A61P; A61P25/00; A61P25/08; C07D233/00; C07D233/54; C07D233/56; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
67 words
A compound of the formula ##STR6## wherein Z is a carbonyl group protected as an acyclic ketal derived from a monohydric straight chain alkanol having from one to four carbon atoms, or a carbonyl group protected as a cyclic ketal wherein the cyclic ketal is selected from the group consisting of ethylenedioxy, 1,3-propylenedioxy, 1,2-propylenedioxy, 2,2-dimethyl-1,3-propylenedioxy, 1-methyl-1,3-propylenedioxy, 1,3-dimethyl-1,3-propylenedioxy, and 2,3-butylenedioxy and the pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
67 words
A compound of the formula ##STR6## wherein Z is a carbonyl group protected as an acyclic ketal derived from a monohydric straight chain alkanol having from one to four carbon atoms, or a carbonyl group protected as a cyclic ketal wherein the cyclic ketal is selected from the group consisting of ethylenedioxy, 1,3-propylenedioxy, 1,2-propylenedioxy, 2,2-dimethyl-1,3-propylenedioxy, 1-methyl-1,3-propylenedioxy, 1,3-dimethyl-1,3-propylenedioxy, and 2,3-butylenedioxy and the pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
16 words
The compound of claim 1 which is 1-[3,3-ethylenedioxy-3-(2-naphthyl)-n-propyl]imidazole and the pharmaceutically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
16 words
The compound of claim 1 which is 1-[3,3-(1,3-propylenedioxy)-3-(2-naphthyl)-n-propyl]imidazole and the pharmaceutically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
16 words
The compound of claim 1 which is 1-[3,3-ethylenedioxy-3-(1-naphthyl)-n-propyl]imidazole and the pharmaceutically acceptable acid addition salts thereof.
Claim 6
Dependent Claim
97 words
A pharmaceutical composition for the prevention and treatment of convulsions or inhibiting gastric secretion in mammals comprising a therapeutically effective amount of a compound of the formula ##STR7## wherein Z is a carbonyl group protected as an acyclic ketal derived from a monohydric straight chain alkanol having from one to four carbon atoms, or a carbonyl group protected as a cyclic ketal wherein the cyclic ketal is selected from the group consisting of ethylenedioxy, 1,3-propylenedioxy, 1,2-propylenedioxy, 2,2-dimethyl-1,3-propylenedioxy, 1-methyl-1,3-propylenedioxy, 1,3-dimethyl-1,3-propylenedioxy, and 2,3-butylenedioxy or a pharmaceutically acceptable acid addition salt thereof; in admixture with a pharmaceutically acceptable, non-toxic carrier.
Claim 7
Dependent Claim
97 words
A pharmaceutical composition for the prevention and treatment of convulsions or inhibiting gastric secretion in mammals comprising a therapeutically effective amount of a compound of the formula ##STR7## wherein Z is a carbonyl group protected as an acyclic ketal derived from a monohydric straight chain alkanol having from one to four carbon atoms, or a carbonyl group protected as a cyclic ketal wherein the cyclic ketal is selected from the group consisting of ethylenedioxy, 1,3-propylenedioxy, 1,2-propylenedioxy, 2,2-dimethyl-1,3-propylenedioxy, 1-methyl-1,3-propylenedioxy, 1,3-dimethyl-1,3-propylenedioxy, and 2,3-butylenedioxy or a pharmaceutically acceptable acid addition salt thereof; in admixture with a pharmaceutically acceptable, non-toxic carrier.
Claim 8
Independent Claim
95 words
A method for treating and preventing convulsions in a mammalian subject comprising administering to said subject in need thereof a therapeutically effective amount of a compound of the formula ##STR8## wherein Z is carbonyl, a carbonyl group protected as an acyclic ketal derived from a monhydric straight chain alkanol having from one to four carbon atoms, or a carbonyl group protected as a cyclic ketal derived from a dihydric alcohol having two or three carbon atoms which may be optionally substituted by one or more methyl groups or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Independent Claim
95 words
A method for treating and preventing convulsions in a mammalian subject comprising administering to said subject in need thereof a therapeutically effective amount of a compound of the formula ##STR8## wherein Z is carbonyl, a carbonyl group protected as an acyclic ketal derived from a monhydric straight chain alkanol having from one to four carbon atoms, or a carbonyl group protected as a cyclic ketal derived from a dihydric alcohol having two or three carbon atoms which may be optionally substituted by one or more methyl groups or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Independent Claim
94 words
A method for inhibiting gastric secretion in a mammalian subject comprising administering to said subject in need thereof a therapeutically effective amount of a compound of the formula ##STR9## wherein Z is carbonyl, a carbonyl group protected as an acyclic ketal derived from a monhydric straight chain alkanol having from one to four carbon atoms, or a carbonyl group protected as a cyclic ketal derived from a dihydric alcohol having two or three carbon atoms which may be optionally substituted by one or more methyl groups or a pharmaceutically acceptable acid addition said thereof.
Claim 11
Independent Claim
94 words
A method for inhibiting gastric secretion in a mammalian subject comprising administering to said subject in need thereof a therapeutically effective amount of a compound of the formula ##STR9## wherein Z is carbonyl, a carbonyl group protected as an acyclic ketal derived from a monhydric straight chain alkanol having from one to four carbon atoms, or a carbonyl group protected as a cyclic ketal derived from a dihydric alcohol having two or three carbon atoms which may be optionally substituted by one or more methyl groups or a pharmaceutically acceptable acid addition said thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-05 | 1985-04-06 | 1985-10-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-05 | 1989-04-06 | 1989-10-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-05 | 1993-04-06 | 1993-10-06 | $7700.00 | Window Closed / Lapsed |