US4156008A
Expired / Lapsed
US
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1-(4-Alkyl-2-aryl-1,3-dioxolan-2-ylmethyl)-1H-imidazoles
Assignee: Janssen Pharmaceutica NV
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Filing: 1976-10-15
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Granted: 1979-05-22
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Expires: 1996-10-15
Abstract
Abstract Novel 1-(4-alkyl-2-aryl-1,3-dioxolan-2-ylmethyl)-1H-imidazoles useful as antifungal and antibacterial agents.
Inventors
- 👤 Jan Heeres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 20:26
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/56; A; A01; A01N; A01N43/00; A01N43/48; A01N43/50; C07C; C07C29/00; C07C29/09; C07C29/10; C07C29/103; C07C29/106; C07C29/36; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D249/00; C07D249/02; C07D249/08; C07D303/00; C07D303/02; C07D303/04; C07D303/08; C07D303/12; C07D303/18; C07D303/20; C07D303/22; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/16; C07D317/18; C07D317/22; C07D317/24; C07D317/30
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
81 words
A chemical compound selected from the group consisting of an imidazole derivative having the formula ##STR9## and the therapeutically acceptable acid addition salts thereof, wherein: R is alkyl having from 2 to 10 carbon atoms; and Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl and naphthalenyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, nitro and cyano.
Claim 2
Dependent Claim
81 words
A chemical compound selected from the group consisting of an imidazole derivative having the formula ##STR9## and the therapeutically acceptable acid addition salts thereof, wherein: R is alkyl having from 2 to 10 carbon atoms; and Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl and naphthalenyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, nitro and cyano.
Claim 3
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
18 words
A chemical compound selected from the group consisting of cis-1-[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 6
Dependent Claim
18 words
A chemical compound selected from the group consisting of cis-1-[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 7
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-[2-(2-chloro-4-fluorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 8
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-[2-(2-chloro-4-fluorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 9
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-[2-(4-bromo-2-chlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 10
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1-[2-(4-bromo-2-chlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 11
Dependent Claim
117 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##STR10## and the therapeutically active acid addition salts and stereochemical optical isomeric forms thereof, wherein: R is alkyl having from 2 to 10 carbon atoms; and Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl and naphthalenyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, nitro and cyano.
Claim 12
Dependent Claim
117 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##STR10## and the therapeutically active acid addition salts and stereochemical optical isomeric forms thereof, wherein: R is alkyl having from 2 to 10 carbon atoms; and Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl and naphthalenyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, nitro and cyano.
Claim 13
Dependent Claim
49 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective amount of a compound selected from the group consisting of 1-[2-(4-bromo-2-chlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically active acid addition salts thereof.
Claim 14
Dependent Claim
49 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective amount of a compound selected from the group consisting of 1-[2-(4-bromo-2-chlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically active acid addition salts thereof.
Claim 15
Dependent Claim
49 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective amount of a compound selected from the group consisting of 1-[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically active acid addition salts thereof.
Claim 16
Dependent Claim
49 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective amount of a compound selected from the group consisting of 1-[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically active acid addition salts thereof.
Claim 17
Dependent Claim
49 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective amount of a compound selected from the group consisting of 1-[2-(2-chloro-4-fluorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically active acid addition salts thereof.
Claim 18
Dependent Claim
49 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective amount of a compound selected from the group consisting of 1-[2-(2-chloro-4-fluorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically active acid addition salts thereof.
References Cited (Backward Citations)
US3575999A
Cited
US3717655A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-21 | 1982-11-20 | 1983-05-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-21 | 1986-11-20 | 1987-05-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-21 | 1990-11-20 | 1991-05-22 | $7700.00 | Window Closed / Lapsed |