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Patent US4291062A successfully refreshed from Google Patents.
US4291062A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions containing urea
Assignee: Phares Pharmaceutical Research NV
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Filing: 1979-06-15
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Granted: 1981-09-22
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Expires: 1999-06-15
Abstract
Abstract Pharmaceutical compositions for application topically or by suppository comprise: (a) a medicament, preferably protected from degradation by moisture by being presented in small particles of a waxy material, (b) from 5% to 40% of an inclusion compound of urea with a straight-chain aliphatic compound, preferably a fatty acid or alcohol, (c) up to 50% of an inert insoluble powder such as starch, (d) from 25% to 90% of an inert carrier, components (a), (b) and (c) being dispersed in (d). The compositions have good storage stability and a smooth texture.
Inventors
- 👤 Steven Leigh
- 👤 Peter J. Ayres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; B; B82; B82Y; B82Y5/00; A61K9/02; Y; Y10; Y10S; Y10S424/00; Y10S424/15
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
123 words
A pharmaceutical composition for application topically or by means of a suppository comprising: (a) an effective concentration of a medicament for administration topically or by means of a suppository, (b) from 5% to 40% of small particles of an inclusion compound of urea with at least one straight-chain aliphatic compound having from 4 to 30 carbon atoms per molecule, (c) up to 50% of a powder that is inert to and insoluble in the remaining ingredients, (d) from 25% to 90% of a carrier material which does not dissolve or react with any of components (a), (b), or (c), optionally together with a thickening agent to provide a composition of the desired consistency, components (a), (b) and (c) being dispersed in component (d).
Claim 2
Dependent Claim
123 words
A pharmaceutical composition for application topically or by means of a suppository comprising: (a) an effective concentration of a medicament for administration topically or by means of a suppository, (b) from 5% to 40% of small particles of an inclusion compound of urea with at least one straight-chain aliphatic compound having from 4 to 30 carbon atoms per molecule, (c) up to 50% of a powder that is inert to and insoluble in the remaining ingredients, (d) from 25% to 90% of a carrier material which does not dissolve or react with any of components (a), (b), or (c), optionally together with a thickening agent to provide a composition of the desired consistency, components (a), (b) and (c) being dispersed in component (d).
Claim 3
Dependent Claim
29 words
A composition as claimed in claim 1, wherein component (a) is from 1% to 30% of small particles of a waxy material containing an effective concentration of the medicament.
Claim 4
Dependent Claim
46 words
A composition as claimed in claim 2, wherein the small particles have an average diameter of from 10 to 60 microns, are composed of a waxy material which melts at a temperature above 37° C., and contain from 4% to 12% by weight of the medicament.
Claim 5
Dependent Claim
30 words
A composition as claimed in claim 1 wherein the aliphatic compound of component (b) is at least one straight-chain fatty acid having from 12 to 18 carbon atoms per molecule.
Claim 6
Dependent Claim
23 words
A composition as claimed in claim 1 wherein component (c) is starch having an average particle diameter of from 1 to 60 microns.
Claim 7
Dependent Claim
17 words
A composition as claimed in claim 1 wherein component (d) has a softening point below 37° C.
Claim 8
Dependent Claim
27 words
A composition as claimed in claim 1 wherein component (d) comprises glyceryl tribehenate 5 to 20%; di-isopropyl adipate 10-40%; and purcellin oil 50 to 85% by weight.
Claim 9
Dependent Claim
57 words
A composition as claimed in claim 2 comprising from 5% to 15% by weight of component (a) which itself contains 4% to 12% by weight of a dispersed medicament, from 10% to 25% by weight of component (b), from 10% to 30% by weight of component (c), and from 50% to 70% by weight of component (d).
References Cited (Backward Citations)
US3981996A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-21 | 1985-03-23 | 1985-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-21 | 1989-03-23 | 1989-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-21 | 1993-03-23 | 1993-09-22 | $7700.00 | Window Closed / Lapsed |