US3981996A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical skin compositions
Assignee: PHA4RES PHARMACUETICAL RESEARCH NV JOHN B GORSIRAWEG NO 6 PO BOX 889 CURACAO NETHERLANDS ANTILLES A Co OF NETHERLANDS ANTILLES
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Filing: 1974-06-20
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Granted: 1976-09-21
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Expires: 1994-06-20
Abstract
Abstract A novel drug delivery system in the form of a skin cream comprises a continuous hydrophobic medium in which there is dispersed an inert water-insoluble powder, the particles of which carry absorbed thereon an aqueous solution or dispersion of a medicament. Improved percutaneous transportation of medicaments by the system is claimed.
Inventors
- 👤 Steven Leigh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 02:40
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/42; A61K31/00; A61K31/16; A61K31/17; A61K47/00; A61K47/30; A61K47/36; A61K8/63; A61K8/72; A61K8/73; A61K8/732; A61K9/00; A61K9/0012; A61K9/0014; A61K9/06; A61K9/14; A61K9/16; A61K9/1605; A61K9/1611; A61K9/1629; A61K9/1652; A61Q; A61Q17/00; A61Q17/04; A61Q19/00; A61Q19/007
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
156 words
A pharmaceutical composition, suitable for external application to human skin, which composition comprises a continuous hydrophobic phase of a pharmaceutically acceptable liquid, semi-solid, gel or solid material, having dispersed therein a pharmaceutically acceptable water-insoluble powder the particles of which carry adsorbed thereon an aqueous solution or dispersion of a member selected from the group consisting of (a) a polar organic compound selected from urea, dimethylsulphoxide, dimethylacetamide, dimeltylformamide, and tetrahydrofurfuryl alcohol, (b) a medicament and (c) mixtures of (a) and (b), said water-insoluble powder being inert to the hydrophobic medium and to the medicament and having an average particle size of greater than about 1 micron, and wherein the proportion of hydrophobic phase is from 20% to 80% by weight of the composition, the proportion of inert powder is from 5% to 60 % by weight of the composition, and the proportion of aqueous solution or dispersion is from 5% to 40% by weight of the composition.
Claim 2
Dependent Claim
156 words
A pharmaceutical composition, suitable for external application to human skin, which composition comprises a continuous hydrophobic phase of a pharmaceutically acceptable liquid, semi-solid, gel or solid material, having dispersed therein a pharmaceutically acceptable water-insoluble powder the particles of which carry adsorbed thereon an aqueous solution or dispersion of a member selected from the group consisting of (a) a polar organic compound selected from urea, dimethylsulphoxide, dimethylacetamide, dimeltylformamide, and tetrahydrofurfuryl alcohol, (b) a medicament and (c) mixtures of (a) and (b), said water-insoluble powder being inert to the hydrophobic medium and to the medicament and having an average particle size of greater than about 1 micron, and wherein the proportion of hydrophobic phase is from 20% to 80% by weight of the composition, the proportion of inert powder is from 5% to 60 % by weight of the composition, and the proportion of aqueous solution or dispersion is from 5% to 40% by weight of the composition.
Claim 3
Dependent Claim
15 words
A composition as claimed in claim 1, wherein the hydrophobic phase comprises white soft paraffin.
Claim 4
Dependent Claim
14 words
A composition as claimed in claim 1, wherein the inert water-insoluble powder comprises starch.
Claim 5
Dependent Claim
21 words
A composition as claimed in claim 1, wherein the average size of the powder is from 1 micron to 30 microns.
Claim 6
Dependent Claim
60 words
A composition as claimed in claim 1, wherein:- the proportion of hydrophobic medium is from 20% to 50% by weight; the proportion of inert powder is from 25% to 50% by weight; the proportion of aqueous solution or dispersion is from 10% to 25% by weight; provided that the proportion of water does not exceed the proportion of hydrophobic phase.
Claim 7
Dependent Claim
19 words
A composition as claimed in claim 1, wherein the medicament is selected from proteolytic and mucolytic enzymes and antibiotics.
Claim 8
Dependent Claim
42 words
A composition as claimed in claim 1, wherein the specific conductivity of the inert powder/aqueous solution or dispersion component lies on the sigmoidal portion of a graph of specific electrical conductivity against amounts of aqueous solution or dispersion adsorbed on the powder.
Claim 9
Dependent Claim
18 words
A composition as claimed in claim 1, having a specific electrical conductivity of at least 0.5 μ mho.
Claim 10
Dependent Claim
44 words
A composition as claimed in claim 1, containing in percent by weight:- ______________________________________
Urea 10%
water 14%
Dry starch (polysaccharide)
27%
White soft paraffin 26%
Sorbitol 1%
Polyoxyethylene fatty ester
9%
Sorbitan monolaurate 2%
Isopropyl myristate 10%
Hydrocortisone and/or a fluorinated
cortico-steroid 1%.
______________________________________
Claim 11
Dependent Claim
27 words
A composition as claimed in claim 1 wherein the polar organic compound is present in an amount of from 5% to 15% by weight of the composition.
Claim 12
Dependent Claim
30 words
A composition as in claim 10 wherein there is also present at least one member of the group of corticosteroids dithranol, salicylates, griseofulvin, and mixtures of Vitamins A and D.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-21 | 1980-03-22 | 1980-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-21 | 1984-03-22 | 1984-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-21 | 1988-03-22 | 1988-09-21 | $7700.00 | Window Closed / Lapsed |