Patent US4291016A successfully refreshed from Google Patents.
US4291016A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enteric coated mixture of 4-(2-hydroxy-3-isopropylamino-propoxy) indole and sodium lauryl sulphate
Assignee: Sandoz AG
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Filing: 1979-12-26
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Granted: 1981-09-22
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Expires: 1999-12-26
Abstract
Abstract The present invention provides a pharmaceutical composition for controlled release of 4-(2-hydroxy-3-isopropylamino-propoxy) indole in the intestinal tract, admixed with sodium lauryl sulphate, and enteric coated.
Inventors
- 👤 Jean-Pierre Nougaret
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 07:01
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
40 words
A pharmaceutical composition having a medicament matrix core comprising a mixture of 4-(2-hydroxy-3-isopropylaminopropoxy)indole, and sodium lauryl sulphate, and a physiologically acceptable film which is resistant to gastric juices and breaks down at pH of 5 or more coating the mixture.
Claim 2
Dependent Claim
40 words
A pharmaceutical composition having a medicament matrix core comprising a mixture of 4-(2-hydroxy-3-isopropylaminopropoxy)indole, and sodium lauryl sulphate, and a physiologically acceptable film which is resistant to gastric juices and breaks down at pH of 5 or more coating the mixture.
Claim 3
Dependent Claim
21 words
A composition according to claim 1 in final form adapted for controlled release of the active agent in the intestinal tract.
Claim 4
Dependent Claim
15 words
A composition according to claim 1 wherein the film is made from hydroxypropyl methylcellulose phthalate.
Claim 5
Dependent Claim
16 words
A composition according to claim 1 wherein the film thickness is from 5 to 100 μm.
Claim 6
Dependent Claim
17 words
A composition according to claim 1 wherein the film is covered by a medicament layer of 4-(2-hydroxy-3-isopropylaminopropoxy)indole.
Claim 7
Dependent Claim
34 words
A composition according to claim 5 wherein the weight ratio of 4-(2-hydroxy-3-isopropylaminopropoxy)indole in the medicament core covered by the film to that in the medicament layer outside the film is from 0.75:1 to 1.25:1.
Claim 8
Dependent Claim
20 words
A composition according to claim 2 in unit dosage form and containing less than 50 mg of sodium lauryl sulphate.
Claim 9
Dependent Claim
25 words
A composition according to claim 1 wherein the weight ratio of sodium lauryl sulphate to 4-(2-hydroxy-3-isopropylaminopropoxy) indole in the mixture is from 0.2:1 to 2:1.
Claim 10
Dependent Claim
15 words
A composition according to claim 8 wherein the weight ratio is from 0.3:1 to 1:1.
Claim 11
Dependent Claim
19 words
A method of increasing the enteral absorption of 4-(2-hydroxy-3-isopropylaminopropoxy)indole which comprises enterally administering the pharmaceutical composition of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-21 | 1985-03-23 | 1985-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-21 | 1989-03-23 | 1989-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-21 | 1993-03-23 | 1993-09-22 | $7700.00 | Window Closed / Lapsed |