US4289851A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for producing cyclosporin derivatives
Assignee: Sandoz AG
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Filing: 1980-03-03
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Granted: 1981-09-15
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Expires: 2000-03-03
Abstract
Abstract The present invention relates to cyclosporin derivatives, especially compounds of formula I ##STR1## wherein A is ##STR2## useful as anti-arthritic agents.
Inventors
- 👤 Rene P. Traber
- 👤 Max Kuhn
- 👤 Hans Hofmann
- 👤 Eugen Harri
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:52
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/64; C07K7/645; A; A61; A61P; A61P29/00; A61P37/00; A61P37/02; A61P37/06; A61K; A61K38/00; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911; Y10S435/945; Y10S930/00; Y10S930/01; Y10S930/19; Y10S930/27
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
83 words
A process for the production of a compound of formula I ##STR5## wherein A is ##STR6## hereinafter referred to as cyclosporin D, dihydroclosporin D or iso-cyclosporin D, respectively, which comprises (a) for the production of cyclosporin D, cultivating a cyclosporin D producing strain of the species Tolypocladium inflatum Gams in the presence of a nutrient medium and isolating cyclosporin D, (b) for the production of dihydrocyclosporin, hydrogenating cyclosporin D, or (c) for the production of isocyclosporin D rearranging cyclosporin D under acidic conditions.
Claim 2
Dependent Claim
83 words
A process for the production of a compound of formula I ##STR5## wherein A is ##STR6## hereinafter referred to as cyclosporin D, dihydroclosporin D or iso-cyclosporin D, respectively, which comprises (a) for the production of cyclosporin D, cultivating a cyclosporin D producing strain of the species Tolypocladium inflatum Gams in the presence of a nutrient medium and isolating cyclosporin D, (b) for the production of dihydrocyclosporin, hydrogenating cyclosporin D, or (c) for the production of isocyclosporin D rearranging cyclosporin D under acidic conditions.
References Cited (Backward Citations)
US3892732A
Cited
US4215199A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-14 | 1985-03-16 | 1985-09-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-14 | 1989-03-16 | 1989-09-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-14 | 1993-03-16 | 1993-09-15 | $7700.00 | Window Closed / Lapsed |