Patent US4285949A successfully refreshed from Google Patents.
US4285949A
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Vincamine derivatives, their preparation and therapeutical use
Assignee: Ajinomoto Omnichem NV SA
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Filing: 1978-12-11
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Granted: 1981-08-25
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Expires: 1998-12-11
Abstract
Abstract The new derivatives of vincamine according to this invention may be represented by the general formula ##STR1## in which R 1 represents a halogen atom and R 2 may represent a hydroxy group whereas R 3 may represent a hydrogen atom, or R 2 may form with R 3 an additional bond. The compounds may be used to treat cardio-circulatory, cerebro-vascular and respiratory insufficiencies.
Inventors
- 👤 Jean A. A. J. Hannart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:04
CPC Classifications
C; C07; C07D; C07D461/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
97 words
A process for preparing a compound of the formula ##STR3## in which: R 1 represents a chlorine atom in the 10-position R 2 and R 3 represent together an additional carbon-carbon bond which comprises the steps of: (a) reacting tabersonine with hydrochloric acid in solution in an alcohol for 2-4 days at room temperature in the presence of a peracid selected from the group consisting of m-chloroperbenzoic acid, perphthalic acid and p-nitroperbenzoic acid, (b) heating the resulting compound of formula I wherein R 2 and R 3 represent respectively OH and H in formic acid at 99%.
Claim 2
Dependent Claim
97 words
A process for preparing a compound of the formula ##STR3## in which: R 1 represents a chlorine atom in the 10-position R 2 and R 3 represent together an additional carbon-carbon bond which comprises the steps of: (a) reacting tabersonine with hydrochloric acid in solution in an alcohol for 2-4 days at room temperature in the presence of a peracid selected from the group consisting of m-chloroperbenzoic acid, perphthalic acid and p-nitroperbenzoic acid, (b) heating the resulting compound of formula I wherein R 2 and R 3 represent respectively OH and H in formic acid at 99%.
Claim 3
Dependent Claim
20 words
A process according to claim 1 in which the heating of step (b) is effected at reflux for four hours.
Claim 4
Dependent Claim
20 words
A compound of formula I as defined in claim 1 being 10-chloro dehydro-14,15 apovincamine (or 10-chloro Δ 14 ,15 apovincamine).
Claim 5
Dependent Claim
51 words
A pharmaceutical composition for use in human and veterinary medicine in treating cardio circulatory, cerebrovascular and respiratory insufficiencies, containing an effective amount of about 1 to 200 mg of an active ingredient comprising at least the compound of formula I as defined in claim 1 together with a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
53 words
A method of treating cardiocirculatory, cerebrovascular and respiratory insufficiency comprising daily administration to a patient in need of such treatment of a pharmaceutical composition comprising 3 mg to 600 mg daily dosage of the vincamine derivative as defined in claim 1 in its base or salt form together with a pharmaceutically acceptable excipient.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-24 | 1985-02-23 | 1985-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-24 | 1989-02-23 | 1989-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-24 | 1993-02-23 | 1993-08-25 | $7700.00 | Window Closed / Lapsed |