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US4282365A
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Dibenz[b,e]oxepin compounds
Assignee: Merck Sharp & Dohme (I.A.) Corp
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Filing: 1978-11-24
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Granted: 1981-08-04
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Expires: 1998-11-24
Abstract
Abstract Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma.
Inventors
- 👤 Joshua Rokach
- 👤 Edward J. Cragoe, Jr.
- 👤 Clarence S. Rooney
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:25
CPC Classifications
C; C07; C07D; C07D313/00; C07D313/02; C07D313/06; C07D313/10; C07D313/12
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
215 words
A compound selected from the group consisting of 6,11-dihydrodibenz[b,e]oxepins having the structural formulae: ##STR29## wherein R 2 and R 3 are the same or different and are members selected from the group consisting of hydrogen, halogen, nitro, amino, N-lower alkylamino, N,N-dilower alkylamino, lower alkanoyl, hydroxy, lower alkoxy, lower alkylthio, trifluoromethylthiol, lower alkylsulfinyl, lower alkylsulfonyl and trifluoromethyl; and where R 2 and R 3 are on adjacent carbon atoms at positions 8 and 9 or 2 and 3, R 2 and R 3 , taken together, are methylenedioxy; R 4 is a member selected from the group consisting of hydrogen, hydroxy, loweralkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, phenylthio, amino, formamido, and 1-imidazolyl; R 5 is a member selected from the group consisting of hydrogen and lower alkyl; R 4 and R 5 , taken together, are a member selected from the group consisting of ═O and ═CH-R 7 wherein R 7 is a member selected from the group consisting of hydrogen and phenyl; and R 1 is a member selected from the group consisting of 5-tetrazolyl and carboxy; with the proviso that R 1 is not 5-tetrazolyl, carboxy or carboxamido when R 4 and R 5 , taken together, are ═O and R 2 and R 3 are hydrogen; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
215 words
A compound selected from the group consisting of 6,11-dihydrodibenz[b,e]oxepins having the structural formulae: ##STR29## wherein R 2 and R 3 are the same or different and are members selected from the group consisting of hydrogen, halogen, nitro, amino, N-lower alkylamino, N,N-dilower alkylamino, lower alkanoyl, hydroxy, lower alkoxy, lower alkylthio, trifluoromethylthiol, lower alkylsulfinyl, lower alkylsulfonyl and trifluoromethyl; and where R 2 and R 3 are on adjacent carbon atoms at positions 8 and 9 or 2 and 3, R 2 and R 3 , taken together, are methylenedioxy; R 4 is a member selected from the group consisting of hydrogen, hydroxy, loweralkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, phenylthio, amino, formamido, and 1-imidazolyl; R 5 is a member selected from the group consisting of hydrogen and lower alkyl; R 4 and R 5 , taken together, are a member selected from the group consisting of ═O and ═CH-R 7 wherein R 7 is a member selected from the group consisting of hydrogen and phenyl; and R 1 is a member selected from the group consisting of 5-tetrazolyl and carboxy; with the proviso that R 1 is not 5-tetrazolyl, carboxy or carboxamido when R 4 and R 5 , taken together, are ═O and R 2 and R 3 are hydrogen; and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
49 words
A compound according to claim 1 wherein R 4 is a member selected from the group consisting of loweralkoxy, loweralkylthio, loweralkylsulfinyl, loweralkylsulfonyl and amino and R 5 is hydrogen; and R 4 is hydrogen and R 5 is loweralkyl; and R 4 and R 5 taken together, is methylene.
Claim 4
Dependent Claim
70 words
A compound according to claim 2 wherein R 4 is a member selected from the group consisting of methoxy, methylthio, methylsulfinyl, methylsulfonyl and amino and R 5 is hydrogen; R 4 is hydrogen and R 5 is methyl; R 4 and R 5 , taken together, is methylene; R 2 and R 3 are hydrogen; and R 1 is a member selected from the group consisting of 5-tetrazolyl and carboxy.
Claim 5
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is 5-tetrazolyl; R 4 is hydrogen and R 5 is methyl.
Claim 6
Dependent Claim
22 words
A compound according to claim 3 wherein R 1 is 5-tetrazolyl and R 4 and R 5 , taken together, is methylene.
Claim 7
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is 5-tetrazolyl; R 4 is methylthio and R 5 is hydrogen.
Claim 8
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is 5-tetrasolyl; R 4 is methylsulfinyl and R 5 is hydrogen.
Claim 9
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is 5-tetrazolyl; R 4 is methylsulfonyl and R 5 is hydrogen.
Claim 10
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is 5-tetrazolyl; R 4 is methoxy and R 5 is hydrogen.
Claim 11
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is 5-tetrazolyl, R 4 is amino and R 5 is hydrogen.
Claim 12
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is carboxy; R 4 is hydrogen and R 5 is methyl.
Claim 13
Dependent Claim
22 words
A compound according to claim 3 wherein R 1 is carboxy and R 4 and R 5 , taken together, is methylene.
Claim 14
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is carboxy; R 4 is methylthio and R 5 is hydrogen.
Claim 15
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is carboxy; R 4 is methylsulfinyl and R 5 is hydrogen.
Claim 16
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is carboxy; R 4 is methylsulfonyl and R 5 is hydrogen.
Claim 17
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is carboxy, R 4 is methoxy and R 5 is hydrogen.
Claim 18
Dependent Claim
20 words
A compound according to claim 3 wherein R 1 is carboxy, R 4 is amino and R 5 is hydrogen.
References Cited (Backward Citations)
GB1119329A
Cited
US3706768A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-03 | 1985-02-02 | 1985-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-03 | 1989-02-02 | 1989-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-03 | 1993-02-02 | 1993-08-04 | $7700.00 | Window Closed / Lapsed |