Xanthone derivatives

Abstract

Abstract XANTHORNE DERIVATIVES OF THE FORMULA: 2-X,9-(O=),R1,R2-XANTHENE IN WHICH X REPRESENTS A CARBOXYL OR 5-(1H)-TETRAZOLYL GROUP; AND R1 AND RI WHICH MAY BE THE SAME OR DIFFERENT EACH REPRESENT A HYDROGEN ATOM, AN ALKYL GROUP CONTAINING FROM 1 TO 4 CARBON ATOMS, A NITRO GROUP, A HALOGEN ATOM OR A GROUP OF THE FORMULA-NR3R4 OR OR3 OR NR5SO2R6 (IN WHICH THE GROUPS R2 AND R4 WHICH MAY BE THE SAME OR DIFFERENT EACH REPRESENT A HYDROGEN ATOM, A PHENYL GROUP, A BENZYL GROUP OR AN ALKYL GROUP WHICH MAY OPTIONALLY BE SUBSTITUTED BY AN ALKOXY GROUP CONTAINING FROM 1 TO 6 CARBON ATOMS, A PHENOXY GROUP, PHENYL GROUP, AN AMINO, ALKYLAMINO OR DIALKYLAMINO GROUP OR BY ONE OR MORE HYDROXY GROUPS; AND IN WHICH R5 IS A HYDROGEN ATOM OR AN ALKYL GROUP CONTAINING FROM 1 TO 6 CARBON ATOMS AND R6 IS AN ALKYL GROUP CONTAINING FROM 1 TO 6 CARBON ATOMS); WITH THE PROVISO THAT WHEN X REPRESENTS A CARBOXYL GROUP R1 AND R2 DO NOT BOTH REPRESENT HYDROGEN ATOMS; AND PHARMACEUTICALLY ACCEPTABLE NON-TONIX SALTS AND ESTERS OF SUCH COMPOUNDS. THESE DERIVATIVES HAVE PHARMACOLOGICAL ACTIVITY AND IT PARTICULAR INHIBIT THE RELEASE OF SPASMOGEN MEDIATORS FROM ANTIGEN-ANTIBODY REACTIONS.

Inventors

• 👤 David Edmund Bays

Bibliographic Details