Patent US4279997A successfully refreshed from Google Patents.
US4279997A
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Process for production of aminoglycoside antibiotics
Assignee: Astellas Pharma Inc
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Filing: 1979-09-05
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Granted: 1981-07-21
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Expires: 1999-09-05
Abstract
Abstract Aminoglycoside antibiotics biochemically transformed from Kanamycin A or Kanamycin B, which are represented by the formula <IMAGE> wherein R1 represents a hydrogen atom or a methyl group and R2 represents an amino group or a hydroxyl group.
Inventors
- 👤 Yoshihiko Oka
- 👤 Hitoshi Ishida
- 👤 Moto Morioka
- 👤 Yoso Numusaki
- 👤 Tsutomu Yamafuji
- 👤 Takashi Osono
- 👤 Hamao Umezawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:36
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; C07H15/222; C07H15/226; C07H15/234; C07H15/236; A; A61; A61P; A61P31/00; A61P31/04; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P19/00; C12P19/44; C12P19/46; C12P19/48; C12P19/485; C12R; C12R2001/00; C12R2001/01; C12R2001/29; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/867
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
63 words
A process for producing aminoglycoside antibiotics represented by the formula ##STR6## wherein R 1 is a hydrogen atom or a methyl group and R 2 represents an amino group or a hydroxyl group, or their pharmacologically acceptable acid addition salts, which comprises cultivating a Gentamicin producing strain of Micromonospora species or a mutant thereof in a medium containing Kanamycin A or Kanamycin B.
Claim 2
Dependent Claim
63 words
A process for producing aminoglycoside antibiotics represented by the formula ##STR6## wherein R 1 is a hydrogen atom or a methyl group and R 2 represents an amino group or a hydroxyl group, or their pharmacologically acceptable acid addition salts, which comprises cultivating a Gentamicin producing strain of Micromonospora species or a mutant thereof in a medium containing Kanamycin A or Kanamycin B.
Claim 3
Dependent Claim
17 words
A process of claim 1 wherein the Gentamicin producing strain of Micromonospora species is Micromonospora sp. K-6993.
Claim 4
Dependent Claim
20 words
A process of claim 1 wherein the mutant of the Gentamicin producing strain of Micromonospora species is Micromonospora sp. K-6993-Y-41.
Claim 5
Dependent Claim
20 words
A process of claim 1 wherein the mutant of Gentamicin producing strain of Micromonospora species is Micromonospora echinospora NRRL 2985-N-6.
References Cited (Backward Citations)
US4045298A
Cited
US3982996A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-20 | 1985-01-19 | 1985-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-20 | 1989-01-19 | 1989-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-20 | 1993-01-19 | 1993-07-21 | $7700.00 | Window Closed / Lapsed |