US4045298A
Expired / Lapsed
US
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Antibiotic XK-62-2 and process for production thereof
Assignee: Abbott Laboratories
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Filing: 1976-06-15
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Granted: 1977-08-30
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Expires: 1996-06-15
Abstract
Abstract The antibiotic XK-62-2 is produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic is accumulated in the culture liquor and is isolated therefrom.
Inventors
- 👤 Takashi Nara
- 👤 Seigo Takasawa
- 👤 Ryo Okachi
- 👤 Isao Kawamoto
- 👤 Mitsuyoshi Yamamoto
- 👤 Seiji Sato
- 👤 Tomoyasu Sato
- 👤 Atsuko Morikawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:31
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; C07H15/222; C07H15/226; C07H15/234; C07H15/236; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/848; Y10S435/849; Y10S435/863; Y10S435/865; Y10S435/873; Y10S435/874; Y10S435/875; Y10S435/879
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
47 words
A process for the production of the antibiotic XK- 62-2 which comprises; culturing a microorganism belonging to the species Micromonospora sagamiensis, which is capable of producing XK-62-2, in a nutrient medium until substantial antibacterial activity is detected in the culture liquor; and thereafter isolating said antibiotic therefrom.
Claim 2
Dependent Claim
47 words
A process for the production of the antibiotic XK- 62-2 which comprises; culturing a microorganism belonging to the species Micromonospora sagamiensis, which is capable of producing XK-62-2, in a nutrient medium until substantial antibacterial activity is detected in the culture liquor; and thereafter isolating said antibiotic therefrom.
Claim 3
Dependent Claim
14 words
A process according to claim 1 wherein said microorganism is Micromonospora sagamiensis ATCC 21826.
Claim 4
Dependent Claim
16 words
A process according to claim 1 wherein said microorganism is Micromonospora sagamiensis var. flava ATCC 21827.
Claim 5
Dependent Claim
16 words
A process according to claim 1 wherein said microorganism is Micromonospora sagamiensis var. nonreducans ATCC 21803.
Claim 6
Dependent Claim
16 words
A process according to claim 1 wherein said microorganism is Micromonospora sagamiensis var. nonreducans ATCC 21949.
Claim 7
Dependent Claim
23 words
A process according to claim 1 which includes the additional step of extracting the antibiotic from the microbial cells before said isolating step.
Claim 8
Dependent Claim
27 words
A process according to claim 1 wherein said culturing is carried out at a temperature of from 25° C to 42° C and at about neutral pH.
Claim 9
Dependent Claim
77 words
A process for the production of the antibiotic XK-62-2, which comprises; culturing an XK-62-2 producing microorganism selected from the group consisting of Micromonospora sagamiensis ATCC 21826, Micromonospora sagmiensis var. flava ATCC 21827, Micromonospora sagamiensis var. nonreducans ATCC 21803 and ATCC 21949, Micromonospora echinospora ATCC 15837, Micromonospora echinospora var. ferruginea ATCC 15836, Micromonospora echinospora var. pallida ATCC 15838 and Micromonospora purpurea ATCC 15835 in a nutrient medium; accumulating XK-62-2 in said medium; and isolating the antibiotic XK-62-2 therefrom.
Claim 10
Dependent Claim
77 words
A process for the production of the antibiotic XK-62-2, which comprises; culturing an XK-62-2 producing microorganism selected from the group consisting of Micromonospora sagamiensis ATCC 21826, Micromonospora sagmiensis var. flava ATCC 21827, Micromonospora sagamiensis var. nonreducans ATCC 21803 and ATCC 21949, Micromonospora echinospora ATCC 15837, Micromonospora echinospora var. ferruginea ATCC 15836, Micromonospora echinospora var. pallida ATCC 15838 and Micromonospora purpurea ATCC 15835 in a nutrient medium; accumulating XK-62-2 in said medium; and isolating the antibiotic XK-62-2 therefrom.
Claim 11
Dependent Claim
27 words
A process according to claim 8 wherein said culturing step is carried out at a temperature from 25° C to 42° C and at about neutral pH.
Claim 12
Dependent Claim
61 words
A process for the production of the antitiotics gentamicin C 1 , gentamicin C 2 and gentamicin C 1a which comprises culturing a microorganism belonging to the species Micromonospora sagamiensis which is capable of producing said antibiotics in a nutrient medium until substantial antibacterial activity is detected in the culture liquor; and thereafter isolating at least one of said antibiotics therefrom.
Claim 13
Dependent Claim
61 words
A process for the production of the antitiotics gentamicin C 1 , gentamicin C 2 and gentamicin C 1a which comprises culturing a microorganism belonging to the species Micromonospora sagamiensis which is capable of producing said antibiotics in a nutrient medium until substantial antibacterial activity is detected in the culture liquor; and thereafter isolating at least one of said antibiotics therefrom.
Claim 14
Dependent Claim
33 words
A process according to claim 10 wherein said microorganism is selected from the group consisting of Micromonospora sagamiensis ATCC 21826, Micromonospora sagamiensis var. flava ATCC 21827 and Micromonospora sagamiensis var. nonreducans ATCC 21803.
Claim 15
Dependent Claim
27 words
A process according to claim 10 wherein said culturing step is carried out at a temperature from 25° C to 42° C and at about neutral pH.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-29 | 1981-02-28 | 1981-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-29 | 1985-02-28 | 1985-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-29 | 1989-02-28 | 1989-08-30 | $7700.00 | Window Closed / Lapsed |