Patent JPS5933673A successfully refreshed from Google Patents.
Patent US4263323A successfully refreshed from Google Patents.
US4263323A
Expired / Lapsed
US
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β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
Assignee: Hassle AB
•
Filing: 1979-04-05
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Granted: 1981-04-21
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Expires: 1999-04-05
Abstract
Abstract Amines of the formula I ##STR1## method of preparing the same and pharmaceutical compositions and method for treating cardiovascular disorders by blocking the β-receptors of the heart in combination with a peripheral vasodilating activity.
Inventors
- 👤 Enar I. Carlsson
- 👤 Gustav B. R. Samuelsson
- 👤 Bo T. Lundgren
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 06:38
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/096
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
65 words
A compound of the formula I ##STR23## wherein R 1 is CH 3 OC 2 H 4 NHCOCH 2 --O--, R 2 and R 3 are hydrogen, methoxy, hydroxy or hydroxymethoxy, provided that R 2 and R 3 are not both hydrogen, X is --O-- or --S-- and n is an integer from 2 to 4, or a therapeutically acceptable salt of such a compound.
Claim 2
Dependent Claim
65 words
A compound of the formula I ##STR23## wherein R 1 is CH 3 OC 2 H 4 NHCOCH 2 --O--, R 2 and R 3 are hydrogen, methoxy, hydroxy or hydroxymethoxy, provided that R 2 and R 3 are not both hydrogen, X is --O-- or --S-- and n is an integer from 2 to 4, or a therapeutically acceptable salt of such a compound.
Claim 3
Dependent Claim
15 words
The compound according to claim 1 which is 3-[2-(4-hydroxyphenoxy)-ethylamino]-1-o-methoxyethylaminocarbonylmethoxyphenoxy-propanol-2, or a therapeutically acceptable salt thereof.
Claim 4
Dependent Claim
51 words
A pharmaceutical preparation for the treatment of cardiovascular disorders in mammals which comprises at least one β-receptor blocking, phenoxyhydroxypropylamine compound according to claim 1 in association with a pharmaceutically acceptable carrier, said compound being present in an amount effective to provide in a dosage unit β-receptor blocking activity in said mammal.
Claim 5
Dependent Claim
18 words
A pharmaceutical preparation according to claim 3 wherein said compound is 3-[2-(4-hydroxyphenoxy)-ethylamino]-1-o-methoxyethylamino-carbonylmethoxyphenoxy-propanol-2, or a therapeutically acceptable salt thereof.
Claim 6
Dependent Claim
36 words
A method of treating cardiovascular disorders comprising administering to a mammal suffering from cardiovascular disorders an amount of a compound according to claim 1 effective to block the beta receptors of the heart of said mammal.
Claim 7
Dependent Claim
19 words
A method of treatment according to claim 5 wherein the compound is 3-[2-(4-hydroxyphenoxy)-ethylamino]-1-o-methoxyethylamino-carbonylmethoxyphenoxy-propanol-2, or a therapeutically acceptable salt thereof.
References Cited (Backward Citations)
GB902617A
Cited
US3192253A
Cited
GB1245148A
Cited
GB1326961A
Cited
GB1433920A
Cited
US4027027A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-20 | 1984-10-20 | 1985-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-20 | 1988-10-20 | 1989-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-20 | 1992-10-20 | 1993-04-21 | $7700.00 | Window Closed / Lapsed |