US4027027A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pyridyloxyalkyleneamino-phenoxy-propanol-2-compounds
Assignee: Novartis Corp
•
Filing: 1975-05-05
•
Granted: 1977-05-31
•
Expires: 1995-05-05
Abstract
Abstract Compounds of the formula <IMAGE> WHEREIN Ar1 and Ar2 denote an optionally substituted aromatic hydrocarbon radical or a monocyclic, monoazacyclic or diazacyclic radical of aromatic character and Alk represents lower alkylene, or salts thereof, exhibit beta -receptor-blocking, blood pressure-lowering and vasodilatory effects and are useful for example in the treatment of arrythmias and angina pectoris, and as blood pressure-lowering agents.
Inventors
- 👤 Knut A. Jaeggi
- 👤 Franz Ostermayer
- 👤 Herbert Schroter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:02
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/63; C07D213/64; A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/33; C07D213/78; C07D213/81; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D239/34; C07D241/00; C07D241/02; C07D241/10; C07D241/14; C07D241/18
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
64 words
A compound of the formula ##STR18## wherein R 1 denotes lower alkyl, lower alkenyl, hydroxyl, lower alkoxy, lower alkenyloxy, halogen, carbamoyl, lower alkylcarbamoyl, lower alkanoylamino or lower alkoxycarbonylamino-lower alkyl, each of the radicals R 2 a and R 2 b denotes hydrogen or methyl, R 3 denotes carbamoyl or N-lower alkylcarbamoyl and n denotes 1 or 2, or pharmaceutically usable salts of such compounds.
Claim 2
Dependent Claim
64 words
A compound of the formula ##STR18## wherein R 1 denotes lower alkyl, lower alkenyl, hydroxyl, lower alkoxy, lower alkenyloxy, halogen, carbamoyl, lower alkylcarbamoyl, lower alkanoylamino or lower alkoxycarbonylamino-lower alkyl, each of the radicals R 2 a and R 2 b denotes hydrogen or methyl, R 3 denotes carbamoyl or N-lower alkylcarbamoyl and n denotes 1 or 2, or pharmaceutically usable salts of such compounds.
Claim 3
Dependent Claim
13 words
A compound of claim 1 which is 1-[2-(5-Carbamoyl-2-pyridyloxy)-ethyl-amino]-3-(2-methyl-phenyloxy)-2-propanol, or pharmaceutically usable salts thereof.
Claim 4
Dependent Claim
13 words
A compound of claim 1 which is 1-[2-(5-Carbamoyl-2-pyridyloxy)-ethylamino]-3-(2-n-propyl-phenyloxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 5
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 3.
Claim 6
Dependent Claim
13 words
A compound of claim 1 which is 1-[2-(3-Carbamoyl-2-pyridyloxy)-ethylamino]-3-(2-methyl-phenyloxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 7
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 5.
Claim 8
Dependent Claim
13 words
A compound of claim 1 which is 1-[2-(2-Carbamoyl-3-pyridyloxy)-ethyl-amino]-3-(2-methyl-phenyloxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 9
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 7.
Claim 10
Dependent Claim
13 words
A compound of claim 1 which is 3-(4-Methylaminocarbonyl-phenyloxy)-1-[2-(3-methyl-2-pyridyloxy)-ethyl-amino]-2-propanol or pharmaceutically usable salts thereof.
Claim 11
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 9.
Claim 12
Dependent Claim
13 words
A compound of claim 1 which is 1-[3-(5-Carbamoyl-2-pyridyloxy)-propylamino]-3-(2-methyl-phenyloxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 13
Dependent Claim
13 words
A compound of claim 1 which is 1-[2-(5-Carbamoyl-2-pyridyloxy)-ethylamino]-3-(2-chlorophenoxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 14
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 12.
Claim 15
Dependent Claim
6 words
1-[1-Methyl-2-(2-carbamoyl-3-pyridyloxy)-ethyl-amino]-3-(2-methyl-phenyloxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 16
Dependent Claim
6 words
1-[1-Methyl-2-(2-carbamoyl-3-pyridyloxy)-ethyl-amino]-3-(2-methyl-phenyloxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 17
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 14.
Claim 18
Dependent Claim
13 words
A compound of claim 1 which is 3-(2-Methyl-phenoxy)-1-[2-(5-methylcarbamoyl-2-pyridyloxy)-ethylamino]-2-propanol or pharmaceutically usable salts thereof.
Claim 19
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 16.
Claim 20
Dependent Claim
13 words
A compound of claim 1 which is 1-[2-(5-Carbamoyl-2-pyridyloxy)-ethylamino]-3-(4-hydroxyphenoxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 21
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 18.
Claim 22
Dependent Claim
13 words
A compound of claim 1 which is 1-[2-(5-Carbamoyl-2-pyridyloxy)-ethylamino]-3-phenoxy-2-propanol or pharmaceutically usable salts thereof.
Claim 23
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 20.
Claim 24
Dependent Claim
13 words
A compound of claim 1 which is 1-[2-(5-Carbamoyl-2-pyridyloxy)-1,1-dimethylethylamino]-3-(2-methyl-phenoxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 25
Dependent Claim
13 words
A compound of claim 1 which is 1-[2-(5-Carbamoyl-2-pyridyloxy)-ethylamino]-3-(2-methoxy-phenoxy)-2-propanol or pharmaceutically usable salts thereof.
Claim 26
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 23.
Claim 27
Dependent Claim
48 words
Method of producing a β-receptor-blocking, bloodpressure lowering and vasodilatory effect in the treatment of arrythmias and angina pectoris in a warm-blooded animal which comprises administering to said mammal an effective amount of one of the compounds of claim 1 or a pharmaceutically usable salt of such a compound.
Claim 28
Dependent Claim
52 words
Method of producing a positively inotropic and chronotropic effect and a stimulating effect on cardiac β-receptors in the treatment of insufficiency of the heart muscle in a warm-blooded animal which comprises administering to said mammal an effective amount of compound of claim 18 or a pharmaceutically usable salt of such a compound.
Claim 29
Dependent Claim
37 words
A pharmaceutical composition producing a β-receptor blocking effect and useful in the treatment of angina pectoris and arrythmias which comprises a β-receptor blocking effective amount of a compound of claim 1 together with a pharmaceutically usable excipient.
Claim 30
Dependent Claim
25 words
The pharmaceutical composition of claim 27 wherein the active compound is 1-[2-(5-carbamoyl-2-pyridyloxy ethylamino]-3-(4-hydroxy-phenoxy)-2-propanol or a pharmaceutically usable salt thereof together with a pharmaceutically usable excipient.
References Cited (Backward Citations)
US3940406A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-30 | 1980-11-29 | 1981-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-30 | 1984-11-29 | 1985-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-30 | 1988-11-29 | 1989-05-31 | $7700.00 | Window Closed / Lapsed |