US3940406A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production
Assignee: Cassella Farbwerke Mainkur AG
•
Filing: 1973-05-21
•
Granted: 1976-02-24
•
Expires: 1993-05-21
Abstract
Abstract The present invention relates to pharmacologically valuable new derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production. The new derivatives of 1-phenoxy-3-amino-propane-2-ol are suitable for the treatment and prophylaxis of diseases of the heart. Some possess pronounced β-adrenalytic or anti-arythmic properties. These new derivatives have the structural formula ##SPC1## Wherein X signifies ##SPC2## And the phenyl nucleus I may be mono-, di- or trisubstituted by alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, phenyl, halogen or the radical --NR 1 R 2 , in which R 1 stands for alkyl or acyl and R 2 for hydrogen or alkyl, together with their aldehyde condensation products and their acid addition salts.
Inventors
- 👤 Thomas Raabe
- 👤 Josef Scholtholt
- 👤 Rolf-Eberhard Nitz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 18:01
CPC Classifications
C; C07; C07D; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/24; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/36; C07D213/38; C07D213/44; C07D213/46; C07D213/50
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
75 words
Derivative of 1-phenoxy-3-amino-propane-2-ol of the formula ##SPC59## in which X denotes ##SPC60## ##SPC61## and the phenol nucleus I may be mono-, di- or tri-substituted by alkyl, alkenyl, alkinyl, cycloalkyl, cyclo-alkenyl, alkoxy, alkenyloxy, alkinyloxy, phenyl, halogen or the radical --NR 1 R 2 , in which R 1 stands for alkyl or an acyl radical derived from an aromatic or aliphatic carboxylic acid and R 2 stands for hydrogen or alkyl and their acid addition salts.
Claim 2
Dependent Claim
75 words
Derivative of 1-phenoxy-3-amino-propane-2-ol of the formula ##SPC59## in which X denotes ##SPC60## ##SPC61## and the phenol nucleus I may be mono-, di- or tri-substituted by alkyl, alkenyl, alkinyl, cycloalkyl, cyclo-alkenyl, alkoxy, alkenyloxy, alkinyloxy, phenyl, halogen or the radical --NR 1 R 2 , in which R 1 stands for alkyl or an acyl radical derived from an aromatic or aliphatic carboxylic acid and R 2 stands for hydrogen or alkyl and their acid addition salts.
Claim 3
Dependent Claim
120 words
Derivative of 1-phenoxy-3-amino-propane-2-ol according to claim 1, wherein the phenyl nucleus I is mono-, di- or tri-substituted by alkyl containing 1 to 4 carbon atoms, alkenyl or alkinyl each containing up to 6 carbon atoms, cycloalkyl or cycloalkenyl with a ring size of 5 to 8 carbon atoms in each case, alkoxy, alkenyloxy, or alkinyloxy containing up to 5 carbon atoms in each case, phenyl, chlorine, or bromine, or the radical --NR 1 R 2 , where R 1 stands for alkyl containing 1 to 4 carbon atoms or an acyl radical derived from an aromatic or aliphatic carboxylic acid containing up to 11 carbon atoms, and R 2 stands for hydrogen or alkyl containing up to 4 carbon atoms.
Claim 4
Dependent Claim
20 words
Derivative of 1-phenoxy-3-amino-propane-2-ol according to claim 1, wherein the phenyl nucleus I is substituted by vinyl, allyl, metallyl, or crotyl.
Claim 5
Dependent Claim
16 words
Derivative of 1-phenoxy-3-amino-propane-2-ol according to claim 1, wherein the phenyl nucleus I is substituted by cyclopentenyl.
Claim 6
Dependent Claim
18 words
Derivative of 1-phenoxy-3-amino-propane-2-ol according to claim 1, wherein the phenyl nucleus I is substituted by cyclopentyl or cyclohexyl.
Claim 7
Dependent Claim
23 words
Derivative of 1-phenoxy-3-amino-propane-2-ol according to claim 1, wherein the phenyl nucleus I is substituted by methoxy, ethoxy, propoxy, butoxy, allyloxy, metallyloxy, or propargyloxy.
Claim 8
Dependent Claim
42 words
Derivative of 1-phenoxy-3-amino-propane-2-ol according to claim 1, wherein the phenyl nucleus I is substituted by the radical --NR 1 R 2 , in which R 1 stands for methyl, ethyl, acetyl, or benzoyl, and R 2 stands for hydrogen, methyl or ethyl.
Claim 9
Dependent Claim
7 words
(-)-1-(3'-β-Pyridyl-3'-hydroxy-1'-methylpropylamino)-3-(o-ethoxy-phenoxy)-propan-2-ol, laevo-rotatory and its acid addition salts.
Claim 10
Dependent Claim
7 words
(-)-1-(3'-β-Pyridyl-3'-hydroxy-1'-methylpropylamino)-3-(o-ethoxy-phenoxy)-propan-2-ol, laevo-rotatory and its acid addition salts.
Claim 11
Dependent Claim
5 words
1-(3'-β-Pyridyl-3'-hydroxy-1'-methyl-propylamino)-3-(p-acetamino-phenoxy)-propan-2-ol. and its addition salts.
Claim 12
Dependent Claim
5 words
1-(3'-β-Pyridyl-3'-hydroxy-1'-methyl-propylamino)-3-(p-acetamino-phenoxy)-propan-2-ol. and its addition salts.
Claim 13
Dependent Claim
6 words
1-(3'-β-Pyridyl-3'-hydroxy-1'-methyl-propylamino)-3-(m-methoxyphenoxy)-propan-2-ol and its acid addition salts.
Claim 14
Dependent Claim
6 words
1-(3'-β-Pyridyl-3'-hydroxy-1'-methyl-propylamino)-3-(m-methoxyphenoxy)-propan-2-ol and its acid addition salts.
Claim 15
Dependent Claim
6 words
1-(3'-β-Pyridyl-3'-hydroxy-1'-methyl-propylamino)-3-(o-chlorophenoxy)-propan-2-ol and its acid addition salts.
Claim 16
Dependent Claim
6 words
1-(3'-β-Pyridyl-3'-hydroxy-1'-methyl-propylamino)-3-(o-chlorophenoxy)-propan-2-ol and its acid addition salts.
Claim 17
Dependent Claim
6 words
1-(3'-β-Pyridyl-3'-hydroxy-1'-methyl-propylamino)-3-(p-methoxyphenoxy)-propan-2-ol and its acid addition salts.
Claim 18
Dependent Claim
6 words
1-(3'-β-Pyridyl-3'-hydroxy-1'-methyl-propylamino)-3-(p-methoxyphenoxy)-propan-2-ol and its acid addition salts.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-23 | 1979-08-25 | 1980-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-23 | 1983-08-25 | 1984-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-23 | 1987-08-25 | 1988-02-24 | $7700.00 | Window Closed / Lapsed |