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US4255566A
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Flavin adenine dinucleotide derivatives and labeled conjugates prepared therefrom
Assignee: Bayer Corp
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Filing: 1980-02-19
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Granted: 1981-03-10
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Expires: 2000-02-19
Abstract
Abstract A flavin adenine dinucleotide (FAD) derivative of the formula: <IMAGE> wherein n is an integer from 2 through 10, and preferably is 6. The derivatives are intermediates in the preparation of FAD-labeled conjugates useful as reagents in specific binding assays for determining ligands (e.g., antigens and haptens) in liquid media such as serum. Also provided are certain FAD-labeled conjugates, particularly an FAD-theophylline conjugate.
Inventors
- 👤 Robert J. Carrico
- 👤 Richard D. Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 16:22
CPC Classifications
C; C07; C07H; C07H21/00; C07H19/00; C07H19/02; C07H19/04; C07H19/16; C07H19/20; C07H19/207; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/535; G01N33/94
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
30 words
A flavin adenine dinucleotide derivative of the formula: ##STR6## wherein Riboflavin--Phos) 2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide and n is an integer from 2 through 10.
Claim 2
Dependent Claim
30 words
A flavin adenine dinucleotide derivative of the formula: ##STR6## wherein Riboflavin--Phos) 2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide and n is an integer from 2 through 10.
Claim 3
Dependent Claim
7 words
The derivative of claim 1 wherein n=6.
Claim 4
Dependent Claim
31 words
A flavin adenine dinucleotide-labeled theophylline conjugate of the formula: ##STR7## wherein Riboflavin--Phos) 2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide and n is an integer from 2 through 10.
Claim 5
Dependent Claim
31 words
A flavin adenine dinucleotide-labeled theophylline conjugate of the formula: ##STR7## wherein Riboflavin--Phos) 2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide and n is an integer from 2 through 10.
Claim 6
Dependent Claim
7 words
The conjugate of claim 3 wherein n=6.
Claim 7
Dependent Claim
42 words
A flavin adenine dinucleotide-labeled phenytoin conjugate of the formula: ##STR8## wherein Riboflavin--Phos) 2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide, φ is phenyl, n is an integer from 2 through 10, and m is an integer from 2 through 6.
Claim 8
Dependent Claim
42 words
A flavin adenine dinucleotide-labeled phenytoin conjugate of the formula: ##STR8## wherein Riboflavin--Phos) 2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide, φ is phenyl, n is an integer from 2 through 10, and m is an integer from 2 through 6.
Claim 9
Dependent Claim
7 words
The conjugate of claim 5 wherein n=6.
Claim 10
Dependent Claim
7 words
The conjugate of claim 6 wherein m=4.
Claim 11
Dependent Claim
42 words
A flavin adenine dinucleotide-labeled phenobarbital conjugate of the formula: ##STR9## wherein Riboflavin--Phos) 2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide, φ is phenyl, n is an integer from 2 through 10, and p is an integer from 2 through 6.
Claim 12
Dependent Claim
42 words
A flavin adenine dinucleotide-labeled phenobarbital conjugate of the formula: ##STR9## wherein Riboflavin--Phos) 2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide, φ is phenyl, n is an integer from 2 through 10, and p is an integer from 2 through 6.
Claim 13
Dependent Claim
7 words
The conjugate of claim 8 wherein n=6.
Claim 14
Dependent Claim
7 words
The conjugate of claim 9 wherein p=4.
References Cited (Backward Citations)
US4171432A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-09 | 1984-09-08 | 1985-03-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-09 | 1988-09-08 | 1989-03-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-09 | 1992-09-08 | 1993-03-10 | $7700.00 | Window Closed / Lapsed |