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US4241048A
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US
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Suspension composition of benzocaine
Assignee: Bristol Myers Co
•
Filing: 1979-05-01
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Granted: 1980-12-23
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Expires: 1999-05-01
Abstract
Abstract A composition containing a therapeutically effective amount of powdered benzocaine suspended in an essentially anhydrous carrier and further containing a copolymer of a vinylpyrrolidone and an alpha-olefin as a crystal growth suppressing agent.
Inventors
- 👤 Taras Durbak
- 👤 Ara Nersesian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:55
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/30; A61K47/32
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
131 words
An anesthetic compositon comprising a therapeutically effective amount of powdered benzocaine suspended in an essentially anhydrous carrier and containing an effective amount of a vinylpyrrolidone and a long chain alpha-olefin copolymer of the formula: ##STR2## wherein R 5 is selected from the group consisting of hydrogen and alkyl, of from 1 to about 180 carbon atoms, p is an integer of from 10 to 100, and wherein the m's independently represent a numerical value of 0 to 1; when m is zero, R 5 is hydrogen; when m is 1, R 5 is selected from the group consisting of hydrogen and alkyl of from 1 to about 180 carbon atoms, and wherein at least one of the m's in at least one of the N-vinylpyrrolidone moieties has the value of 1;
Claim 2
Dependent Claim
131 words
An anesthetic compositon comprising a therapeutically effective amount of powdered benzocaine suspended in an essentially anhydrous carrier and containing an effective amount of a vinylpyrrolidone and a long chain alpha-olefin copolymer of the formula: ##STR2## wherein R 5 is selected from the group consisting of hydrogen and alkyl, of from 1 to about 180 carbon atoms, p is an integer of from 10 to 100, and wherein the m's independently represent a numerical value of 0 to 1; when m is zero, R 5 is hydrogen; when m is 1, R 5 is selected from the group consisting of hydrogen and alkyl of from 1 to about 180 carbon atoms, and wherein at least one of the m's in at least one of the N-vinylpyrrolidone moieties has the value of 1;
Claim 3
Dependent Claim
42 words
the ratio of the said copolymer to benzocaine present is in the range of from about 0.05 parts to about 4 parts of copolymer to 1 part of benzocaine which is sufficient to significantly suppress crystal growth of said benzocaine on storage.
Claim 4
Dependent Claim
42 words
the ratio of the said copolymer to benzocaine present is in the range of from about 0.05 parts to about 4 parts of copolymer to 1 part of benzocaine which is sufficient to significantly suppress crystal growth of said benzocaine on storage.
Claim 5
Dependent Claim
14 words
A composition according to claim 1 in which said carrier is a liquid carrier.
Claim 6
Dependent Claim
35 words
A composition according to claim 2 in which the ratio of the copolymer to benzocaine present is in the range of from about 0.2 parts to about 1part of copolymer to 1 part of benzocaine.
Claim 7
Dependent Claim
35 words
A composition according to claims 1, 2 or 3 in which the benzocaine is present in the range of from about 1% to about 30% by weight based on the total weight of the composition.
Claim 8
Dependent Claim
35 words
A composition according to claim 1, 2 or 3 in which the benzocaine is present in the range of from about 2% to about 20% by weight based on the total weight of the composition.
Claim 9
Dependent Claim
13 words
A composition according to claim 1 in the form of a foamable liquid.
Claim 10
Dependent Claim
13 words
A composition according to claim 1 in the form of an aerosol product.
Claim 11
Dependent Claim
13 words
A composition according to claim 1 in which said carrier is a solid.
Claim 12
Dependent Claim
33 words
A composition according to claim 8 in which the ratio of copolymer to benzocaine present is in the range from about 0.2 parts to about 1part of copolymer to 1 part of benzocaine.
Claim 13
Dependent Claim
34 words
A composition according to claims 8 or 9 in which the benzocaine is present in the range of from about 1% to about 30% by weight based on the total weight of the composition.
Claim 14
Dependent Claim
34 words
A composition according to claims 8 or 9 in which the benzocaine is present in the range of from about 2% to about 20% by weight based on the total weight of the composition.
Claim 15
Dependent Claim
12 words
A composition according to claim 8 in the form of a suppository.
Claim 16
Dependent Claim
12 words
A composition according to claim 8 in the form of an ointment.
Claim 17
Dependent Claim
12 words
A composition according to claim 8 in the form of a gel.
Claim 18
Dependent Claim
13 words
A composition according to claim 8 in the form of an anhydrous cream.
Claim 19
Dependent Claim
23 words
A composition according to claim 1 in which said copolymer has a molecular weight in the range of from about 7,000 to 20,000.
Claim 20
Dependent Claim
13 words
A composition according to claim 16 in which said copolymer is PVP-Eicosene copolymer.
Claim 21
Dependent Claim
13 words
A composition according to claim 16 in which said copolymer is PVP-Hexadecene copolymer.
Claim 22
Dependent Claim
35 words
A composition according to claim 18 in which the ratio of said copolymer to benzocaine is in the range of from about 0.05 parts to about 4 parts of copolymer to 1 part of benzocaine.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-23 | 1984-06-23 | 1984-12-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-23 | 1988-06-23 | 1988-12-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-23 | 1992-06-23 | 1992-12-23 | $7700.00 | Window Closed / Lapsed |