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US4237129A
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Derivatives of thiazolidinecarboxylic acids and related acids
Assignee: ER Squibb and Sons LLC
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Filing: 1979-06-28
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Granted: 1980-12-02
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Expires: 1999-06-28
Abstract
Abstract New substituted derivatives of thiazolidine-, thiazane- and related carboxylic acids which have the general formula ##STR1## are useful as angiostensin converting enzyme inhibitors.
Inventors
- 👤 Miguel A. Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 00:52
CPC Classifications
C; C07; C07D; C07D265/00; C07D265/28; C07D265/30; C07D277/00; C07D277/02; C07D277/04; C07D277/06; C07D279/00; C07D279/04; C07D279/10; C07D279/12
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
114 words
A compound of the formula ##STR12## wherein R is hydroxy or lower alkoxy; R 1 , R 2 , R 5 and R 6 each is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl or mercapto-lower alkylene; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR13## X is S, SO or SO 2 ; m is 1, 2 or 3; n is 0, 1 or 2 and m+n is 3; p is 0 or 1; and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
Claim 2
Dependent Claim
114 words
A compound of the formula ##STR12## wherein R is hydroxy or lower alkoxy; R 1 , R 2 , R 5 and R 6 each is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl or mercapto-lower alkylene; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR13## X is S, SO or SO 2 ; m is 1, 2 or 3; n is 0, 1 or 2 and m+n is 3; p is 0 or 1; and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
Claim 3
Dependent Claim
62 words
A compound as in claim 1 wherein R is hydroxy or lower alkoxy; R 1 , R 2 , R 5 and R 6 each is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl or mercapto-lower alkylene; R 4 is hydrogen, lower alkanoyl or benzoyl; X is sulfur; m is 2; n is 1; and p is 0 or 1.
Claim 4
Dependent Claim
55 words
A compound as in claim 1 wherein R is hydroxy, methoxy or ethoxy; R 1 , R 2 , R 3 , R 5 and R 6 each is hydrogen, methyl or ethyl; R 4 is hydrogen, acetyl or benzoyl; X is sulfur; m is 2; n is 1; and p is 0 or 1.
Claim 5
Dependent Claim
11 words
A compound as in claim 1 wherein R 4 is hydrogen.
Claim 6
Dependent Claim
11 words
A compound as in claim 1 wherein R 4 is acetyl.
Claim 7
Dependent Claim
11 words
A compound as in claim 1 wherein R 4 is benzoyl.
Claim 8
Dependent Claim
11 words
A compound as in claim 1 wherein R 4 is ##STR14##
Claim 9
Dependent Claim
10 words
A compound as in claim 1 wherein R is hydroxy.
Claim 10
Dependent Claim
10 words
A compound as in claim 1 wherein p is 1.
Claim 11
Dependent Claim
10 words
A compound as in claim 1 wherein X is sulfur.
Claim 12
Dependent Claim
41 words
A compound as in claim 10 wherein R is hydroxy; R 1 , R 2 , R 3 , R 5 and R 6 each is hydrogen; R 4 is acetyl; m is 2; n is 1 and p is 1.
Claim 13
Dependent Claim
40 words
A compound as in claim 10 wherein R is hydroxy; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 each is hydrogen; m is 2; n is 1; and p is 1.
Claim 14
Dependent Claim
117 words
A composition comprising a compound of the formula ##STR15## wherein R is hydroxy or lower alkoxy; R 1 , R 2 , R 5 and R 6 each is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl or mercapto-lower alkylene; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR16## X is S, SO or SO 2 ; m is 1, 2 or 3; n is 0, 1 or 2 and m+n is 3; p is 0 or 1; and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
Claim 15
Dependent Claim
117 words
A composition comprising a compound of the formula ##STR15## wherein R is hydroxy or lower alkoxy; R 1 , R 2 , R 5 and R 6 each is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl or mercapto-lower alkylene; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR16## X is S, SO or SO 2 ; m is 1, 2 or 3; n is 0, 1 or 2 and m+n is 3; p is 0 or 1; and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
Claim 16
Independent Claim
126 words
A method for reducing blood pressure which comprises administering a composition comprising a compound of the formula ##STR17## wherein R is hydroxy or lower alkoxy; R 1 , R 2 , R 5 and R 6 each is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl or mercapto-lower alkylene; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR18## X is S, SO or SO 2 ; m is 1, 2 or 3; n is 0, 1 or 2 and m+n is 3; p is 0 or 1; and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
Claim 17
Independent Claim
126 words
A method for reducing blood pressure which comprises administering a composition comprising a compound of the formula ##STR17## wherein R is hydroxy or lower alkoxy; R 1 , R 2 , R 5 and R 6 each is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl or mercapto-lower alkylene; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR18## X is S, SO or SO 2 ; m is 1, 2 or 3; n is 0, 1 or 2 and m+n is 3; p is 0 or 1; and basic salts thereof; wherein the terms lower alkyl, lower alkoxy and lower alkylene refer to groups having 1 to 7 carbon atoms and the term lower alkanoyl refers to groups having up to 7 carbon atoms.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-02 | 1984-06-02 | 1984-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-02 | 1988-06-02 | 1988-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-02 | 1992-06-02 | 1992-12-02 | $7700.00 | Window Closed / Lapsed |