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US3886149A Expired / Lapsed US ⏱️ 0.0 years remaining

Amino substituted dithiocarbonylthioacetyl cephalosporins

Assignee: ER Squibb and Sons LLC
•
Filing: 1972-06-01
•
Granted: 1975-05-27
•
Expires: 1992-06-01
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Abstract

Abstract Amino substituted dithiocarbonylthioacetylcephalosporins of the general formula R1 is hydrogen, lower alkyl, aralkyl, aryl or certain heterocyclic groups; R2 and R3 each is hydrogen or lower alkyl; R4 is lower alkyl, aryl or aralkyl; R5 is hydrogen or lower alkyl; R6 is hydrogen, cycloalkyl, lower alkyl; or together R5 and R6 complete certain nitrogen heterocyclics; X is hydrogen, hydroxy, lower alkanoyloxy, aroyloxy, aralkanoyloxy, SR7, OR7, the radical of a nitrogen base, a quaternary ammonium radical, or together X and R represent a bond linking carbon and oxygen in a lactone ring; R7 is lower alkyl; and n is 1, 2, 3 or 4; are useful as antibacterial agents. WHEREIN R is hydrogen, lower alkyl, aralkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, a salt forming ion or the group

Inventors

  • 👤 Uwe D Treuner
  • 👤 Hermann Breuer

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-28 03:10
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 73 words
A COMPOUND OF THE FORMULA 2-(R-OOC-),3-(X-CH2-),7-(R5-N(-R6)-(C(-R2)(-R3))N-SWHEREIN R IS HYDROGEN, LOWER ALKYL, ALKALI METAL, TRIMETHYLSILYL OR R4-COO-CH2-; C(=S)-S-CH(-R1)-CO-NH-)-2-CEPHEM R1 IS PHENYL; R2, R3 AND R5 EACH IS HYDROGEN OR LOWER ALKYL; R4 IS LOWER ALKYL, PHENYL OR PHENYL-LOWER ALKYL; R6 IS LOWER ALKYL OR R5 AND R6 TOGETHER COMPLETE ONE OF THE UNSUBSTITUTED HETEROCYCLICS PIPERIDINO, MORPHOLINO, THIAMORPHOLINO OR PIPERAZINO; X IS HYDROGEN, HYDROXY OR LOWER ALKANOLYLOXY; AND N IS 1, 2, 3 OR 4.
Claim 2
Dependent Claim 73 words
A COMPOUND OF THE FORMULA 2-(R-OOC-),3-(X-CH2-),7-(R5-N(-R6)-(C(-R2)(-R3))N-SWHEREIN R IS HYDROGEN, LOWER ALKYL, ALKALI METAL, TRIMETHYLSILYL OR R4-COO-CH2-; C(=S)-S-CH(-R1)-CO-NH-)-2-CEPHEM R1 IS PHENYL; R2, R3 AND R5 EACH IS HYDROGEN OR LOWER ALKYL; R4 IS LOWER ALKYL, PHENYL OR PHENYL-LOWER ALKYL; R6 IS LOWER ALKYL OR R5 AND R6 TOGETHER COMPLETE ONE OF THE UNSUBSTITUTED HETEROCYCLICS PIPERIDINO, MORPHOLINO, THIAMORPHOLINO OR PIPERAZINO; X IS HYDROGEN, HYDROXY OR LOWER ALKANOLYLOXY; AND N IS 1, 2, 3 OR 4.
Claim 3
Dependent Claim 25 words
A compound as in claim 1 wherein R1 is phenyl, R, R2, R3 and X each is hydrogen, R5 and R6 each is lower alkyl.
Claim 4
Dependent Claim 17 words
A compound as in claim 2 wherein each lower alkyl group is methyl and n is 1.
Claim 5
Dependent Claim 28 words
A compound as in claim 1 wherein R1 is phenyl, R, R2 and R3 each is hydrogen, R5 and R6 each is lower alkyl and X is acetoxy.
Claim 6
Dependent Claim 17 words
A compound as in claim 4 wherein each lower alkyl group is methyl and n is 2.
Claim 7
Dependent Claim 17 words
A compound as in claim 4 wherein each lower alkyl group is methyl and n is 1.
Claim 8
Dependent Claim 17 words
A compound as in claim 2 wherein each lower alkyl group is ethyl and n is 1.
Claim 9
Dependent Claim 17 words
A compound as in claim 4 wherein each lower alkyl group is ethyl and n is 1.
Claim 10
Dependent Claim 13 words
A compound as in claim 1 wherein R is hydrogen, alkali metal or

References Cited (Backward Citations)

US3431259A Cited
US3573298A Cited
US3578661A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-05-26 1978-11-25 1979-05-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-05-26 1982-11-25 1983-05-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-05-26 1986-11-25 1987-05-27 $7700.00 Window Closed / Lapsed

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