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US4235886A
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Cyclic hexapeptide somatostatin analogs
Assignee: Merck and Co Inc
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Filing: 1979-10-31
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Granted: 1980-11-25
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Expires: 1999-10-31
Abstract
Abstract Somatostatin analogs are prepared wherein a cyclic hexapeptide contains a secondary amino acid which replaces seven of the ring amino acids of somatostatin. The cyclic hexapeptides are easier to synethesize, have a longer duration of activity, and many have a greater level of activity than somatostatin. The compounds have the properties of inhibiting the release of glucagon, growth hormone and insulin. Certain of the compounds also are capable of inhibiting the release of gastric acid secretions. The compounds are particularly useful in the treatment of acromegaly, diabetes, diabetic retinopathy and peptic ulcers. These cyclic hexapeptides are prepared by the solid phase method.
Inventors
- 👤 Roger M. Freidinger
- 👤 Daniel F. Veber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 11:30
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K14/6555; A; A61; A61P; A61P1/00; A61P1/04; A61P27/00; A61P27/02; A61P3/00; A61P3/08; A61P3/10; A61P43/00; A61P5/00; A61P5/02; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
128 words
A compound having the formula: ##STR15## wherein X is (CH 2 ) n wherein n is 0, 1 or 2 or sulfur; Y is (CH 2 ) m wherein m is 0, 1 or 2 or sulfur such that the sulfur may be in any position along the chain; R 1 and R 2 are independently lower alkyl, benzyl, substituted benzyl wherein the substituent may be one or two of loweralkyl, halogen, hydroxy, amino, nitro or loweralkoxy; and loweralkyl substituted with a 5- or 6-membered heterocyclic ring; R 3 is 3-indolylmethyl or substituted 3-indolylmethyl wherein the substituent may be loweralkyl, loweralkoxy or halogen; and R 4 is loweralkyl, hydroxyloweralkyl, benzyl, carboxyloweralkyl, aminoloweralkyl or substituted hydroxy benzyl wherein the substituent may be loweralkyl, loweralkoxy, hydroxy, halogen, amino or nitro.
Claim 2
Dependent Claim
128 words
A compound having the formula: ##STR15## wherein X is (CH 2 ) n wherein n is 0, 1 or 2 or sulfur; Y is (CH 2 ) m wherein m is 0, 1 or 2 or sulfur such that the sulfur may be in any position along the chain; R 1 and R 2 are independently lower alkyl, benzyl, substituted benzyl wherein the substituent may be one or two of loweralkyl, halogen, hydroxy, amino, nitro or loweralkoxy; and loweralkyl substituted with a 5- or 6-membered heterocyclic ring; R 3 is 3-indolylmethyl or substituted 3-indolylmethyl wherein the substituent may be loweralkyl, loweralkoxy or halogen; and R 4 is loweralkyl, hydroxyloweralkyl, benzyl, carboxyloweralkyl, aminoloweralkyl or substituted hydroxy benzyl wherein the substituent may be loweralkyl, loweralkoxy, hydroxy, halogen, amino or nitro.
Claim 3
Dependent Claim
52 words
A compound of claim 1 wherein X and Y are (CH 2 ) n and n is 1; R 1 and R 2 are as defined in claim 1; R 3 is 3-indolylmethyl or substituted indolylmethyl wherein the substituent is methoxy or fluoro; and R 4 is methyl, ethyl, hydroxymethyl or hydroxyethyl.
Claim 4
Dependent Claim
31 words
A compound of claim 2 wherein: X and Y are methylene; R 1 and R 2 are as defined in claim 1; R 3 is 3-indolylmethyl; and R 4 is hydroxyethyl.
Claim 5
Dependent Claim
9 words
The compound of claim 2 which is cyclo (Pro-Tyr-D-Trp-Lys-Thr-Phe).
Claim 6
Dependent Claim
9 words
The compound of claim 2 which is cyclo (Pro-Phe-D-Trp-Lys-Thr-Phe).
Claim 7
Dependent Claim
9 words
The compound of claim 2 which is cyclo (Pro-Phe-L-Trp-Lys-Thr-Phe).
Claim 8
Dependent Claim
9 words
The compound of claim 2 which is cyclo (Pro-Phe-D-5F-Trp-Lys-Thr-Phe).
Claim 9
Dependent Claim
9 words
The compound of claim 2 which is cyclo (Pro-Phe-L-5F-Trp-Lys-Thr-Phe).
Claim 10
Dependent Claim
9 words
The compound of claim 2 which is cyclo (Pro-Phe-D-Trp-Lys-Ser-Phe).
Claim 11
Dependent Claim
9 words
The compound of claim 2 which is cyclo (Pro-Phe-D-Trp-Lys-Thr-p-Cl-Phe).
Claim 12
Dependent Claim
25 words
A method for inhibiting the release of growth hormone which comprises administering to an animal an effective amount of a cyclic hexapeptide of claim 1.
Claim 13
Dependent Claim
37 words
A pharmaceutical composition for inhibiting the release of growth hormone comprising a therapeutically effective amount of the cyclic hexapeptide of claim 1 or the non-toxic acid addition salts thereof in a pharmaceutically acceptable liquid or solid carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-25 | 1984-05-26 | 1984-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-25 | 1988-05-26 | 1988-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-25 | 1992-05-26 | 1992-11-25 | $7700.00 | Window Closed / Lapsed |