Patent US2725823A successfully refreshed from Google Patents.
US4140767A
Expired / Lapsed
US
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Somatostatin analogs
Assignee: Merck and Co Inc
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Filing: 1977-12-01
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Granted: 1979-02-20
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Expires: 1997-12-01
Abstract
Abstract {PG,1 Bicyclic somatostatin analogs and pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These analogs have the property of inhibiting the release of growth hormone without affecting the level of gastric secretions or without affecting the level of gastric secretions, insulin and glucagon in humans and animals. The compounds are particularly useful in the treatment of acromegaly and diabetic retinopathy. Due to the bicyclic structure, these analogs are resistant to enzymatic metabolism and have a longer duration of activity than somatostatin.
Inventors
- 👤 Daniel F. Veber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 11:13
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K14/6555; A; A61; A61P; A61P43/00; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
5 words
The compounds having the formula:
Claim 2
Dependent Claim
5 words
The compounds having the formula:
Claim 3
Dependent Claim
6 words
The compounds having the formula: ##STR22##
Claim 4
Dependent Claim
6 words
The compounds having the formula: ##STR22##
Claim 5
Dependent Claim
30 words
A pharmaceutical composition comprising a therapeutically effective amount of the peptide having the structure: ##STR23## and non-toxic acid addition salts thereof in a pharmaceutically acceptable liquid or solid carrier thereof.
Claim 6
Dependent Claim
30 words
A pharmaceutical composition comprising a therapeutically effective amount of the peptide having the structure: ##STR23## and non-toxic acid addition salts thereof in a pharmaceutically acceptable liquid or solid carrier thereof.
References Cited (Backward Citations)
US3997517A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |