Patent US4234735A successfully refreshed from Google Patents.
US4234735A
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US
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Guanidino imidazoles and thiazoles
Assignee: Syngenta Ltd
•
Filing: 1979-08-13
•
Granted: 1980-11-18
•
Expires: 1999-08-13
Abstract
Abstract The invention relates to guanidine derivatives of imidazoles and thiazoles which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manufacture, to pharmaceutical compositions containing them and to methods of using such guanidine derivatives and compositions. The guanidine derivatives are of the general formula I: <IMAGE> I in which X is S or NH, Y is CH2, a direct bond or a vinylene radical, m is 0 to 4 and n is 1 to 4, R1 is hydrogen, halogen or alkyl, R2 is hydrogen, alkyl, alkanoyl or aroyl, A is a 3,4-dioxocyclobuten-1,2-diyl radical or C=Z in which Z is O, S, NCN, NNO2, CHNO2, NCONH2, C(CN)2, NCOR3, NCO2R3, NSO2R3 or NR4 in which R3 is alkyl or aryl and R4 is hydrogen or alkyl, B is alkoxy or alkylthio or NR5R6 in which R5 and R6 are independently hydrogen, alkyl, alkenyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl or dialkylaminoalkyl; and the salts thereof.
Inventors
- 👤 Derrick F. Jones
- 👤 Tobias O. Yellin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 19:54
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; A; A61; A61P; A61P1/00; A61P1/04; A61P43/00; C07D233/00; C07D233/54; C07D233/66; C07D233/88; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/38; C07D277/44; C07D277/48
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
92 words
A guanidine compound of the following formula (III): ##STR25## wherein X is sulphur or NH; Y is a direct bond, a methylene radical or a cis- or trans-vinylene radical; m is 0 to 4; n is 1 to 4; R 1 is a hydrogen or halogen atom or an alkyl radical of 1 to 6 carbon atoms; and R 2 is a hydrogen atom, an alkyl radical of 1 to 10 carbon atoms, an alkanoyl radical of 1 to 6 carbon atoms or an aroyl radical of 7 to 11 carbon atoms.
Claim 2
Dependent Claim
92 words
A guanidine compound of the following formula (III): ##STR25## wherein X is sulphur or NH; Y is a direct bond, a methylene radical or a cis- or trans-vinylene radical; m is 0 to 4; n is 1 to 4; R 1 is a hydrogen or halogen atom or an alkyl radical of 1 to 6 carbon atoms; and R 2 is a hydrogen atom, an alkyl radical of 1 to 10 carbon atoms, an alkanoyl radical of 1 to 6 carbon atoms or an aroyl radical of 7 to 11 carbon atoms.
Claim 3
Dependent Claim
12 words
The compound of claim 1, wherein in formula (III), X is sulphur.
Claim 4
Dependent Claim
14 words
The compound of claim 1, wherein in formula (III), Y is a direct bond.
Claim 5
Dependent Claim
14 words
The compound of claim 1, wherein in formula (III), Y is a trans-vinylene radical.
Claim 6
Dependent Claim
16 words
The compound of claim 1, wherein in formula (III), m is 0 and n is 4.
Claim 7
Dependent Claim
21 words
The compound of claim 1, wherein in formula (III), Y is a direct bond, m is 0 and n is 4.
Claim 8
Dependent Claim
16 words
The compound of claim 1, wherein in formula (III), R 1 is hydrogen, bromine or methyl.
Claim 9
Dependent Claim
13 words
The compound of claim 1, wherein in formula (III), R 2 is hydrogen.
Claim 10
Dependent Claim
35 words
The compound of claim 1, wherein in formula (III), X is sulphur; Y is a direct bond; m and n total 2, 3, 4 or 5; R 1 is hydrogen; and R 2 is hydrogen
Claim 11
Dependent Claim
10 words
The compound of claim 1, wherein said compound is 2-guanidino-4-(4-aminobutyl)-thiazole.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-18 | 1984-05-19 | 1984-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-18 | 1988-05-19 | 1988-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-18 | 1992-05-19 | 1992-11-18 | $7700.00 | Window Closed / Lapsed |